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bioRxiv (Cold Spring Harbor Laboratory)
Cold Spring Harbor Laboratory
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78 counted works of 104 linked
| Year | Title | Academics | Sources |
|---|---|---|---|
| 2026 | A class of metallohydrolases expands bile salt hydrolase activity in the gut | Pamela Chang | GS |
| 2026 | Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of White Adipose Tissue | Stacy Malaker | OA GS |
| 2026 | A scalable design for proximity-inducing molecules | Neel H. Shah | GS |
| 2026 | B3GNT7 regulates mucin glycosylation and protects against colitis and infection in progress | Stacy Malaker | CV GS |
| 2026 | Chemical interactions in polyethylene glycol-induced condensates lead to an anomalous FRET response from a flexible linker-fluorescent protein crowding sensor | Caitlin Davis | GS |
| 2026 | Dynamic redistribution of eIF4F controls cap-dependent translation initiation | Ruben L Gonzalez Jr | GS |
| 2026 | Expanding the methionine toolkit: L-cyanohomoalanine as a multifunctional analog | Caitlin Davis | GS |
| 2026 | Exploring Solvent Exposure of a Histidine Triad as a Modulator of Structure, Molecular Motion, and Ligand Binding in GM-CSF in progress | Brenda Rubenstein | CV OA GS |
| 2026 | Glycosite Mapping and in situ Imaging of MUC2 Glycopeptides via On- slide Digestion with Mucinase StcE | Stacy Malaker | CV OA GS |
| 2026 | Identification of substrates of the protein tyrosine phosphatase PTP1B using in situ site-specific photo-crosslinking | Neel H. Shah | GS |
| 2026 | Label-Free AI-Classification of Subcellular Organelles Based on Optical Photothermal Infrared Images | Caitlin Davis | GS |
| 2026 | Mapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding in progress | Stacy Malaker | CV OA GS |
| 2026 | Modulating radical propagation in proteins by proton-coupled electron transfer and hydrogen bonding | Nandini Ananth | GS |
| 2026 | msaGUI: Multispectral Analysis Graphical User Interface for Ratiometric Analysis and Background Correction | Caitlin Davis | GS |
| 2026 | Multi-Peptide Prompting Enables In-Context Learning in Protein Language | Erik Thiede | GS |
| 2026 | Oxidized protein states define metastatic fitness in lung cancer | Brian Liau | GS |
| 2026 | Programming T cells for intercellular genome editing | Kai Chen | GS |
| 2026 | ɸX174 Bacteriophage Viability Predicted by Protein Biophysical Modeling in progress | Brenda Rubenstein | CV OA GS |
| 2026 | Site-specific O-glycans dictate lacritin multimerization in tears in progress | Stacy Malaker | CV OA GS |
| 2026 | The Z-shaped N-terminal Domain of Atg11 Coordinates Atg9 Recruitment in Selective Autophagy | Michael J. Ragusa | GS |
| 2025 | A clinical-stage oncology compound selectively targets drug-resistant cancers in progress | Patrick Holland | CV OA |
| 2025 | Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2 | Neel H. Shah | GS |
| 2025 | An Opioid Efficacy Switch for Reversible Optical Control of Peripheral Analgesia in progress | Dirk Trauner | CV OA |
| 2025 | A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function | Xiaowei Zhuang | CV OA |
| 2025 | Compound Mutations in Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations | Brenda Rubenstein | CV OA GS |
| 2025 | Counting particles could give wrong probabilities in Cryo-Electron Microscopy | Erik Thiede | GS |
| 2025 | Cryo-electron microscopy ensemble optimization using individual particles and physical constraints | Erik Thiede | GS |
| 2025 | DENDRO: Recovery and denoising of whole-tree dendritic voltage from 2D voltage movies in progress | Adam Cohen | CV OA |
| 2025 | FastConformation: A Standalone ML-Based Toolkit for Modeling and Analyzing Protein Conformational Ensembles at Scale in progress | Brenda Rubenstein | CV OA GS |
| 2025 | Genetic landscape of DNMT3A R882H reveals mechanism of aberrant oligomerization | Brian Liau | GS |
| 2025 | Inhibition of SQSTM1/p62 oligomerization and Keap1 sequestration by the Cullin-3 adaptor SHKBP1 | Jeremy M. Baskin | GS |
| 2025 | Molecular mechanisms of small molecules that stabilize oligomers of a phase separating disordered protein in progress | Paul Robustelli | CV OA |
| 2025 | Monomer binding modes of small molecules that modulate the amyloid aggregation kinetics of hIAPP in progress | Paul Robustelli | CV OA |
| 2025 | Optical Control of Membrane Fluidity Modulates Protein Secretion | Dirk Trauner | CV OA |
| 2025 | Phase separation oppositely modulates G-quadruplex and i-motif DNA folding in the nuclei of living cells | Caitlin Davis | GS |
| 2025 | Phase Separation Tunes the Stability and Dynamics of G-quadruplex and i-Motif DNA in the Nuclei of Living Cells | Caitlin Davis | GS |
| 2025 | Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis | Brian Liau | GS |
| 2025 | Profiling tyrosine kinase substrate recognition using bacterial peptide display and deep sequencing | Neel H. Shah | GS |
| 2025 | Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for … in progress | Stacy Malaker | CV OA GS |
| 2025 | Strategic modulation of polarity and viscosity sensitivity of bimane molecular rotor-based fluorophores for imaging α-synuclein | E. James Petersson; Tobias Baumgart | GS |
| 2025 | Voltage dynamics of dendritic integration and back-propagation in vivo in progress | Adam Cohen | CV OA |
| 2024 | A dynamic compositional equilibrium governs mRNA recognition by eIF3 | Ruben L Gonzalez Jr | GS |
| 2024 | Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes | Brian Liau | GS |
| 2024 | Density-based optimization for unbiased, reproducible clustering applied to single molecule localization microscopy | Laura J. Kaufman | GS |
| 2024 | Development of cell-free platforms for discovering, characterizing, and engineering post-translational modifications in progress | Emily Balskus | CV OA |
| 2024 | Dynamic network regulating phosphatidic acid homeostasis revealed using membrane editing coupled to proximity labeling | Jeremy M. Baskin | GS |
| 2024 | Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening | David M. Chenoweth | GS |
| 2024 | KBTBD4 cancer hotspot mutations drive neomorphic degradation of HDAC1/2 corepressor complexes | Brian Liau | GS |
| 2024 | Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery in progress | Ralph Kleiner | CV OA |
| 2024 | Mobility of Four Structural Regions Drives Isoform-Specific Properties of Plant LPOR | Brenda Rubenstein | GS |
| 2024 | Off-pore” nucleoporins relocalize heterochromatic breaks through phase separation | David M. Chenoweth | GS |
| 2024 | Post-translational modifications control phase transitions of tau | Patrick Holland | GS |
| 2024 | VASP phase separation with priming proteins of fast endophilin mediated endocytosis modulates actin polymerization | Tobias Baumgart | GS |
| 2023 | A bioelectrical phase transition patterns the first beats of a vertebrate heart | Adam Cohen | CV OA |
| 2023 | A diversified, widespread microbial gene cluster encodes homologs of methyltransferases involved in methanogenesis. in progress | Emily Balskus | CV OA |
| 2023 | All-optical mapping of cAMP transport reveals rules of sub-cellular localization in progress | Adam Cohen | CV OA |
| 2023 | Biliatresone treatment of pregnant mice causes changes in bile metabolism and liver inflammation in their offspring | Jeffrey D. Winkler | OA GS |
| 2023 | Cell type-specific translational regulation by human DUS enzymes in progress | Ralph Kleiner | CV OA |
| 2023 | Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation | Ruben L Gonzalez Jr | GS |
| 2023 | Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome | Ruben L Gonzalez Jr | GS |
| 2023 | CTCF/cohesin organize the ground state of chromatin-nuclear speckle association | Brian Liau | GS |
| 2023 | Dopamine receptor D2 confers colonization resistance via gut microbial metabolites related record | Pamela Chang | GS |
| 2023 | Electrostatic interactions dictate bile salt hydrolase substrate preference | Pamela Chang | GS |
| 2023 | Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway | Brian Liau | GS |
| 2023 | IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation | Jason M. Crawford | GS |
| 2023 | Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma in progress | Stacy Malaker | OA GS |
| 2023 | Oleic acid differentially affects de novo lipogenesis in adipocytes and hepatocytes | Caitlin Davis | GS |
| 2023 | Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation in progress | Dirk Trauner | CV OA |
| 2023 | Signatures of jamming in the cellular Potts model | Laura J. Kaufman | GS |
| 2023 | The mechanism of mRNA activation | Ruben L Gonzalez Jr | GS |
| 2023 | Three-dimensional single-cell transcriptome imaging of thick tissues | Xiaowei Zhuang | CV OA |
| 2023 | Transcriptome-wide RNA structure probing with temporal resolution in progress | Ralph Kleiner | CV OA |
| 2023 | Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells | Stacy Malaker | OA GS |
| 2022 | A systematic comparison of current bioinformatic tools for glycoproteomics data | Stacy Malaker | CV OA GS |
| 2022 | Dendritic branch structure compartmentalizes voltage-dependent calcium influx in cortical layer 2/3 pyramidal cells | Adam Cohen | CV OA GS |
| 2022 | Drug addiction mutations unveil a methylation ceiling in EZH2-mutant lymphoma | Brian Liau | GS |
| 2022 | Mechanistic implications of the interaction of the soluble substrate-binding protein with a type II ABC importer | Ruben L Gonzalez Jr | GS |
| 2022 | PLEKHA5 regulates mitotic progression by promoting APC/C localization to microtubules | Jeremy M. Baskin | GS |
| 2022 | Realtime observation of ATP-driven single B12 molecule translocation through BtuCD-F | Ruben L Gonzalez Jr | GS |
| 2022 | Revealing the human mucinome | Stacy Malaker | CV OA GS |
| 2022 | Three-dimensional interrogation of cell types and instinctive behavior in the periaqueductal gray | Xiaowei Zhuang | CV OA GS |
| 2021 | FRAME-tags: a Scalable Palette of Genetically Encoded Ratiometric Fluorescent Barcodes for Multiplexed Live Cell Tracking in progress | Virginia W. Cornish | CV OA |
| 2021 | Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase | David M. Chenoweth | GS |
| 2021 | NusG links transcription and translation in Escherichia coli extracts | Ruben L Gonzalez Jr | GS |
| 2020 | Endophilin recruitment via GPCR interactions enables membrane curvature generation in the absence of anionic lipids | Tobias Baumgart | GS |
| 2020 | Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes | Megan L. Matthews | OA GS |
| 2020 | Latrophilins are essential for endothelial junctional fluid shear stress mechanotransduction | Jason M. Crawford | GS |
| 2020 | Lipid-based, protein-based, and steric interactions synergize to facilitate transmembrane signaling stimulated by antigen-clustering of IgE receptors | Barbara A. Baird | GS |
| 2020 | Molecular, spatial and projection diversity of neurons in primary motor cortex revealed by in situ single-cell transcriptomics | Xiaowei Zhuang | OA GS |
| 2020 | Spatial organization of the transcriptome in individual neurons | Xiaowei Zhuang | CV OA GS |
| 2020 | Structural and molecular determinants of CCS-mediated copper activation of MEK1/2 | Megan L. Matthews | OA GS |
| 2019 | All-optical electrophysiology reveals brain-state dependent changes in hippocampal subthreshold dynamics and excitability | Adam Cohen | CV OA GS |
| 2019 | Chemical precision glyco-mutagenesis by glycosyltransferase engineering in living cells in progress | Stacy Malaker | OA GS |
| 2019 | Evaluation of Reproducible and Transparent Research Practices in Pulmonology Publications | Caleb Smith | GS |
| 2019 | Liquid condensation drives telomere clustering during ALT | David M. Chenoweth | GS |
| 2019 | Mammalian Y RNAs are modified at discrete guanosine residues with N-glycans in progress | Stacy Malaker | CV OA GS |
| 2019 | Multiplexed, bioorthogonal labeling of multicomponent, biomolecular complexes using genomically encoded, non-canonical amino acids | Ruben L Gonzalez Jr | GS |
| 2019 | (p) ppGpp directly regulates translation initiation during entry into quiescence | Ruben L Gonzalez Jr | GS |
| 2019 | Structure elucidation of colibactin | Jason M. Crawford | GS |
| 2018 | Authorship inflation and author gender in pulmonology research | Caleb Smith | GS |
| 2018 | Innate immune priming by cGAS as a preparatory countermeasure against RNA virus infection | Jason M. Crawford | GS |
| 2018 | Real-time structural dynamics of late steps in bacterial translation initiation visualized using time-resolved cryogenic electron microscopy | Ruben L Gonzalez Jr | GS |
| 2018 | Recruitment of human eIF4G1 or DAP5 to the 5’untranslated regions of a subset of cellular mRNAs drives cap-independent translation | Ruben L Gonzalez Jr | GS |
| 2017 | Two-photon photoactivated voltage imaging in tissue with an Archaerhodopsin-derived reporter in progress | Adam Cohen | CV OA |