Journal

Nature Chemical Biology

OpenAlex S51309854

Published here

101 counted works of 101 linked

YearTitleAcademicsSources
2026 Membrane editing with proximity labeling reveals regulators of lipid homeostasis Jeremy M. Baskin GS
2026 Microtubule depolymerization at kinetochores restricts anaphase spindle elongation David M. Chenoweth GS
2026 Singlet oxygen spills sterol secrets: Proximity labeling Jeremy M. Baskin GS
2026 Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells Stacy Malaker CV OA GS
2025 All roads lead to OSBP: Lipid metabolism Jeremy M. Baskin GS
2025 Building the first base editors: Genome editing Brian Liau GS
2025 PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates Christina Woo CV OA
2025 Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1 Brian Liau GS
2023 A small molecule inhibitor prevents gut bacterial genotoxin production. Emily Balskus CV OA
2023 Assigning Functionality to Cysteines by Base Editing of Cancer Dependency Genes David R. Liu CV
2023 Base editor scanning charts the DNMT3A activity landscape Brian Liau GS
2023 Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma Brian Liau GS
2023 Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2 Squire J. Booker GS
2023 Profiling dynamic RNA-protein interactions using small molecule-induced RNA editing Ralph Kleiner CV OA
2023 Structural basis of colibactin activation by the ClbP peptidase. Emily Balskus CV OA
2022 Discovery and Molecular Basis of Subtype-Selective Cyclophilin Inhibitors David R. Liu CV
2022 Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor Sarah Slavoff GS
2021 A community resource for paired genomic and metabolomic data mining Jason M. Crawford GS
2021 Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation Ralph Kleiner CV OA
2021 Discovering new biology with drug-resistance alleles Brian Liau GS
2021 Escherichia coli small molecule metabolism at the host–microorganism interface Jason M. Crawford GS
2021 Laboratory Evolution of a Sortase Enzyme that Modifies Amyloid-β Protein David R. Liu CV
2021 Oncohistone mutations enhance chromatin remodeling and alter cell fate Tom Muir CV OA GS
2021 Reconstruction of Evolving Gene Variants and Fitness from Short Sequencing Reads David R. Liu CV
2021 Structural basis for non-radical catalysis by TsrM, a radical SAM methylase Squire J. Booker GS
2021 Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase Christina Woo CV OA
2021 There is a lock for every key: MEMBRANE PROTEINS Jeremy M. Baskin GS
2021 Voices of chemical biology Megan L. Matthews GS
2020 A basic motif anchoring ISWI to the nucleosome acidic patch regulates nucleosome spacing Tom Muir CV OA GS
2020 A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway Joshua Rabinowitz GS
2020 Chromatin as a key consumer in the metabolic economy Tom Muir CV OA GS
2020 m6A-binding YTHDF proteins promote stress granule formation Xiaowei Zhuang CV OA GS
2020 Multiplexed genomic encoding of non-canonical amino acids for labeling large complexes Ruben L Gonzalez Jr GS
2020 Rolf Huisgen (1920–2020) Dirk Trauner CV OA
2020 Targeted desialylation overcomes glyco-immune checkpoints and potentiates the anticancer immune response in vivo Stacy Malaker CV OA GS
2020 The Developing Toolkit of Continuous Directed Evolution David R. Liu CV
2019 An excreted small molecule promotes C. elegans reproductive development and aging Frank C. Schroeder GS
2019 CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML Brian Liau GS
2019 Optical Control of Sphingosine-1-Phosphate Formation and Function Dirk Trauner CV OA GS
2019 Side-Chain Determinants of Biopolymer Function During Iterated Selection and Replication David R. Liu CV
2019 Substrate-Selective Inhibitors that Reprogram the Activity of Insulin-Degrading Enzyme David R. Liu CV
2018 Acetylation blocks DNA damage-induced chromatin ADP-ribosylation Tom Muir CV OA GS
2018 A De Novo Enzyme Catalyzes a Life-Sustaining Reaction in E. coli Michael Hecht CV OA
2018 Continuous Directed Evolution of Proteins with Improved Soluble Expression David R. Liu CV
2018 Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system Christopher J. Chang GS
2018 How many human proteoforms are there? Sarah Slavoff; Tom Muir CV OA GS
2018 Optical Control of L-Type Ca2+ Channels Using a Diltiazem Photoswitch Dirk Trauner CV OA GS
2017 A human microprotein that interacts with the mRNA decapping complex Sarah Slavoff GS
2017 A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis. Emily Balskus CV OA
2017 Bisphosphoglycerate mutase controls 3-phosphoglycerate concentration and thereby serine pathway flux Tom Muir CV OA GS
2017 Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring. Emily Balskus CV OA
2017 Continuous Directed Evolution of Aminoacyl-tRNA Synthetases David R. Liu CV GS
2017 Crystal Structures Reveal an Elusive Functional Domain of Pyrrolysyl-tRNA Synthetase David R. Liu CV
2017 GlcN6P cofactor serves multiple catalytic roles in the glmS ribozyme Sharon Hammes-Schiffer CV GS
2017 Optogenetic control of kinetochore function David M. Chenoweth GS
2017 Ubiquitin Utilizes an Acidic Surface Patch to Alter Chromatin Structure Tom Muir CV OA GS
2016 A two-step activation mechanism controls the histone methyltransferase Suv39h1 Tom Muir CV OA GS
2016 Copper regulates cyclic-AMP-dependent lipolysis Christopher J. Chang GS
2016 Histone deacetylase 6 structure and molecular basis of catalysis and inhibition David W. Christianson GS
2016 Metabolite concentrations, fluxes and free energies imply efficient enzyme usage Joshua Rabinowitz GS
2016 Photoswitchable Diacylglycerols Enable Optical Control of Protein Kinase C Dirk Trauner CV OA GS
2016 Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus Frank C. Schroeder GS
2015 Chemical Proteomics Reveals a γH2AX-53BP1 Interaction in the DNA Damage Response Ralph Kleiner CV OA
2015 Minimum information about a biosynthetic gene cluster. Emily Balskus CV OA
2015 Searching for harmony in transition-metal signaling Christopher J. Chang GS
2015 Small Molecule-Triggered Cas9 Protein with Improved Genome-Editing Specificity David R. Liu CV GS
2014 Design of activated serine-containing catalytic triads with atomic-level accuracy. Megan L. Matthews CV OA GS
2014 Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase. Megan L. Matthews CV OA GS
2014 Electrophilic Activity-Based RNA Probes Reveal a Self-Alkylating RNA for RNA Labeling David R. Liu CV
2014 Negative Selection And Stringency Modulation Enable Phage-Assisted Continuous Evolution (PACE) of Enzymes with Altered Specificity David R. Liu CV
2014 Sponge symbionts play defense. Emily Balskus CV OA
2013 A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr Squire J. Booker GS
2013 Direct Detection of Protein Histidine Phosphorylation Using a Pan Antibody Tom Muir CV OA GS
2013 Induction of innate and adaptive immunity in vivo by delivery of poly dA:dT to dendritic cells Tom Muir CV OA GS
2013 Peptidomic discovery of short open reading frame–encoded peptides in human cells Sarah Slavoff GS
2012 Chromatin as an Expansive Canvas for Chemical Biology Tom Muir CV OA GS
2012 Discovery and Biological Characterization of Geranylated RNA in Bacteria David R. Liu CV
2012 Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles Ralph Kleiner; David R. Liu CV OA
2011 Chemistry and biology of reactive oxygen species in signaling or stress responses Christopher J. Chang GS
2011 H2B Ubiquitylation Disrupts Local and Higher-Order Chromatin Compaction Tom Muir CV OA GS
2011 Nox2 redox signaling maintains essential cell populations in the brain Christopher J. Chang GS
2011 Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase David W. Christianson GS
2011 α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition Joshua Rabinowitz GS
2010 An In Vitro Translation, Selection and Amplification System for Peptide Nucleic Acid David R. Liu; Ralph Kleiner CV OA
2010 Branched Intermediate Formation Stimulates Peptide Bond Cleavage in the Mxe GyrA Intein Protein Splicing Reaction Tom Muir CV OA GS
2010 Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation Tom Muir CV OA GS
2010 Synthetic Immunology to Engineer Human Immunity David Spiegel CV OA
2009 Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli Joshua Rabinowitz GS
2009 LC/MS Analysis of Cellular RNA Reveals NAD-Linked RNA David R. Liu CV
2009 Natural Amino Acids Do Not Require Their Native tRNAs for Efficient Selection by the Ribosome Virginia W. Cornish; Ruben L Gonzalez Jr CV OA GS
2008 Biomimetic Synthesis of the IDO Inhibitors Exiguamine A and B Dirk Trauner CV OA GS
2008 Navigating the RNA folding landscape Ruben L Gonzalez Jr GS
2008 Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily Squire J. Booker GS
2008 Synthetic fluorescent sensors for studying the cell biology of metals Christopher J. Chang GS
2007 Molecular imaging of hydrogen peroxide produced for cell signaling Christopher J. Chang GS
2007 Post-translational Enzyme Activation in an Animal Via Conditional Protein Splicing Tom Muir CV OA GS
2007 Small-molecule pheromones that control dauer development in Caenorhabditis elegans Frank C. Schroeder GS
2006 Allosteric Control of an Ionotropic Glutamate Receptor with an Optical Switch Dirk Trauner CV OA GS
2006 How Pathogenic Bacteria Evade Mammalian Sabotage in the Battle for Iron David R. Liu CV GS
2005 A Glimpse at the Grail Dirk Trauner CV OA
2005 Photochemical Tools for Remote-Control of Ion Channels in Excitable Cells Dirk Trauner CV OA GS