Journal

Nature Biotechnology

ISSN 0733-222X · Nature Portfolio

OpenAlex S106963461

Published here

49 counted works of 50 linked

YearTitleAcademicsSources
2026 AI-guided Re-design of Laboratory-Evolved Reverse Transcriptases Enhances Prime Editing in Human Cells and in Animals David R. Liu CV OA
2026 Directed Evolution of Small RNA-Stabilizing Motifs that Improve Prime Editing David R. Liu CV
2026 Evolution of Botulinum Neurotoxin Serotype X Proteases to Induce Inflammatory Cell Death in Cancer Cells David R. Liu CV
2026 Mechanistic Machine Learning for Prediction of Prime Editing Outcomes David R. Liu CV
2026 Self-Assembling Protein Nanoparticles for Cytosolic Delivery of Therapeutic Macromolecules in progress David R. Liu CV
2026 Virus-like Particles Enable Targeted Gene Engineering and Pooled CRISPR Screening in Primary Human Myeloid Cells David R. Liu CV
2025 Branched, Chemically Modified Poly(A) Tails Enhance the Translation Capacity of mRNA David R. Liu CV
2025 Directed Evolution of Engineered Virus-Like Particles with Improved Production and Transduction Efficiencies David R. Liu CV
2025 High Throughput Evaluation of Genetic Variants with Prime Editing Sensor Libraries David R. Liu CV
2025 Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein Kai Chen GS
2024 Adenine Transversion Editors Enable Precise, Efficient A•T-To-C•G Base Editing in Mammalian Cells and Embryos David R. Liu CV
2024 A Prime Editor Mouse to Model a Broad Spectrum of Somatic Mutations In Vivo David R. Liu CV
2024 Efficient Prime Editing in Mouse Brain, Liver and Heart with Dual AAVs David R. Liu CV
2024 Efficient Prime Editing in Two-Cell Mouse Embryos Using PEmbryo David R. Liu CV
2024 Engineered Virus-Like Particles for Transient Delivery of Prime Editor Ribonucleoprotein Complexes In Vivo David R. Liu CV
2023 Design of a mucin-selective protease for targeted degradation of cancer-associated mucins Stacy Malaker CV OA GS
2023 Evolution of an Adenine Base Editor into a Small, Efficient Cytosine Base Editor with Low Off-Target Activity David R. Liu CV
2023 High-Throughput Continuous Evolution of Compact Cas9 Variants Targeting Single-Nucleotide-Pyrimidine PAMs David R. Liu CV
2023 Massively parallel knock-in engineering of human T cells Sarah Slavoff GS
2023 Time-tagged ticker tapes for intracellular recordings Adam Cohen CV OA GS
2022 CRISPR-Free Base Editors with Enhanced Activity and Expanded Targeting Scope in Mitochondrial and Nuclear DNA David R. Liu CV
2022 Engineered pegRNAs Improve Prime Editing Efficiency David R. Liu CV GS
2022 Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning Neel H. Shah GS
2022 Programmable Deletion, Replacement, Integration, and Inversion of Large DNA Sequences with Twin Prime Editing David R. Liu CV GS
2021 Efficient C•G-to-G•C Base Editors Developed Using CRISPRi Screens, Target-Library Analysis and Machine Learning David R. Liu CV
2020 Continuous Evolution of SpCas9 Variants Compatible with Non-G PAMs David R. Liu CV GS
2020 Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors David R. Liu CV GS
2020 Genome Editing with CRISPR-Cas Nucleases, Base Editors, Transposases, and Prime Editors David R. Liu CV GS
2020 Phage-Assisted Evolution of an Adenine Base Editor with Enhanced Cas Domain Compatibility and Activity David R. Liu CV GS
2020 Prime Genome Editing in Rice and Wheat David R. Liu CV GS
2020 Programmable m6A Modification of Cellular RNA with a Cas13-Directed Methyltransferase David R. Liu CV GS
2019 Circularly Permuted and Modified-PAM Base Editors with Diversified Targeting Scope David R. Liu CV
2019 Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors David R. Liu GS
2019 Continuous Evolution of Base Editors with Expanded Target Compatibility and Improved Activity David R. Liu CV GS
2019 CRISPResso2: Accurate and Rapid Analysis of Genome Editing Data from Nucleases and Base Editors David R. Liu CV
2019 CRISPResso2 provides accurate and rapid genome editing sequence analysis David R. Liu GS
2018 Improving Cytidine and Adenine Base Editors by Expression Optimization and Ancestral Reconstruction David R. Liu CV GS
2017 Increasing the Genome-Targeting Scope and Precision of Base Editing with Engineered Cas9-Cytidine Deaminase Fusions David R. Liu CV GS
2015 Accelerating innovation for rapid diagnostics and targeted antibacterials Daniel Paul Carpenter CV GS
2015 Cationic Lipid-Mediated Delivery of Proteins Enables Efficient Protein-Based Genome Editing In Vitro and In Vivo David R. Liu CV GS
2014 Enzyme clustering accelerates processing of intermediates through metabolic channeling Joshua Rabinowitz GS
2014 Fusion of Catalytically Inactive Cas9 to FokI Nuclease Improves the Specificity of Genome Modification David R. Liu CV GS
2013 High-Throughput Profiling of Off-Target DNA Cleavage Reveals RNA-Programmed Cas9 Nuclease Specificity David R. Liu CV GS
2012 Discovering ligand-receptor interactions Sarah Slavoff GS
2011 New fluorescent probes for super-resolution imaging Xiaowei Zhuang CV OA GS
2008 Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy Joshua Rabinowitz GS
2007 Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes Jeremy M. Baskin GS
2002 Nucleic Acid Evolution and Minimization by Nonhomologous Random Recombination David R. Liu CV
2000 Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin Jon Ellman OA GS
1994 Recombinant Proteins Can Be Released From E. Coli Cells By Repeated Cycles of Freezing and Thawing Michael Hecht CV OA GS