Publications

2018 DNA repair: Unconventional lesions require unconventional repair Seth Herzon · Biochemistry 2 2017 A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A1. Evidence for a Structural Revision Seth Herzon · Chemical Science 4 2017 A modular and enantioselective synthesis of the pleuromutilin antibiotics Seth Herzon · Science 77 2017 ClbS is a cyclopropane hydrolyase that confers colibactin resistance Seth Herzon · Journal of the American Chemical Society 86 2017 Development of a modular synthetic route to (+)-pleuromutilin, (+)- 12-epi-mutilins, and related structures Seth Herzon · Journal of the American Chemical Society 54 2017 Domain-targeted metabolomics delineates the heterocycle assembly steps of colibactin biosynthesis Seth Herzon · Journal of the American Chemical Society 59 2017 Hydroheteroarylation of unactivated alkenes using N-methoxyheteroarenium salts Seth Herzon · Journal of the American Chemical Society 158 2017 Molecular basis of gut microbiome-associated colorectal cancer: A synthetic perspective Seth Herzon · Journal of the American Chemical Society 48 2017 Scalable synthesis of a key intermediate for the production of pleuromutilin-based antibiotics Seth Herzon · Organic Letters 11 2017 Structure and functional analysis of ClbQ, an unusual intermediate-releasing thioesterase from the colibactin biosynthetic pathway Seth Herzon · ACS Chemical Biology 51 2017 The mechanism of action of (–)-lomaiviticin A Seth Herzon · Accounts of Chemical Research 33 2016 A mechanistic model for colibactin-induced genotoxicity Seth Herzon · Journal of the American Chemical Society 93 2016 Characterization of cardiac glycoside natural products as potent inhibitors of DNA double-strand break repair by a whole cell double immunofluorescence assay Seth Herzon · Journal of the American Chemical Society 54 2016 Convergent and modular synthesis of candidate precolibactins. Structural revision of precolibactin A Seth Herzon · Journal of the American Chemical Society 59 2016 Intermolecular hydropyridylation of unactivated alkenes Seth Herzon · Journal of the American Chemical Society 208 2016 Mechanism of nucleophilic activation of (–)-lomaiviticin A Seth Herzon · Journal of the American Chemical Society 17 2016 Stereoselective multicomponent reactions using zincate nucleophiles: β-dicarbonyl synthesis and functionalization Seth Herzon · Organic Letters 14 2016 Structural basis for DNA cleavage by the potent antiproliferative agent (–)-lomaiviticin A Seth Herzon · Proceedings of the National Academy of Sciences 36 2016 Synthesis of ketones and esters from heteroatom-functionalized alkenes by cobalt-mediated hydrogen atom transfer Seth Herzon · The Journal of Organic Chemistry 43 2015 A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials Seth Herzon · Nature 66 2015 Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines Seth Herzon · Journal of the American Chemical Society 19 2015 Multigram synthesis of 1-O-acetyl-3-O-(4-methoxybenzyl)-4-N-(9-fluorenylmethoxycarbonyl)-4-N-methyl-L-pyrrolosamine Seth Herzon · Tetrahedron Letters 1 2015 Non-classical selectivities in the reduction of alkenes by cobalt-mediated hydrogen atom transfer Seth Herzon · Chemical Science 107 2015 Synthesis of 1,3-aminoalcohols, 1,3-diols, amines, and carboxylic acids from terminal alkynes Seth Herzon · The Journal of Organic Chemistry · needs review 38 2015 The discovery of a novel route to highly-substituted α-tropolones enables expedient entry to the core of the gukulenins Seth Herzon · Organic Letters · needs review 31 2014 A highly active and air-stable ruthenium complex for the ambient temperature anti-Markovnikov reductive hydration of terminal alkynes Seth Herzon · Journal of the American Chemical Society · needs review 73 2014 A method for the selective hydrogenation of alkenyl halides to alkyl halides Seth Herzon · Journal of the American Chemical Society · needs review 195 2014 Analysis of diazofluorene DNA binding and damaging activity. DNA cleavage by a synthetic monomeric diazofluorene Seth Herzon · Angewandte Chemie International Edition 24 2014 Broad-spectrum catalysts for the ambient temperature anti-Markovnikov hydration of alkynes Seth Herzon · Angewandte Chemie International Edition · needs review 57 2014 Hasubanan and acutumine alkaloids Seth Herzon · The Alkaloids: Chemistry and Biology · needs review 24 2014 Ruthenium-catalyzed anti-Markovnikov hydration and reductive hydration of terminal alkynes Seth Herzon · ChemInform · needs review 0 2014 Scope and limitations of 2-deoxy and 2,6-dideoxyglycosyl bromides as donors for the synthesis of β-2-deoxy and β-2,6-dideoxyglycosides Seth Herzon · Organic Letters · needs review 63 2014 Substrate-modified functional group reactivity: Hasubanan and acutumine alkaloid syntheses Seth Herzon · The Journal of Organic Chemistry · needs review 22 2014 Temporal separation of catalytic activities allows anti-Markovnikov reductive functionalization of terminal alkynes Seth Herzon · Nature Chemistry · needs review 54 2014 The cytotoxicity of (–)-lomaiviticin A arises from induction of double-strand breaks in DNA Seth Herzon · Nature Chemistry 83 2013 A practical method for regiocontrolled one-carbon ring contraction Seth Herzon · Tetrahedron · needs review 6 2013 Development of enantioselective synthetic routes to the hasubanan and acutumine alkaloids Seth Herzon · The Journal of Organic Chemistry · needs review 48 2013 Direct synthesis of N-glycosides by the reductive glycosylation of azides using protected and native carbohydrate donors Seth Herzon · Angewandte Chemie International Edition · needs review 20 2013 Insights into lomaiviticin biosynthesis. Isolation and structure elucidation of (–)-homoseongomycin Seth Herzon · Journal of Natural Products 27 2013 Total syntheses of (–)-acutumine and (–)-dechloroacutumine Seth Herzon · Angewandte Chemie International Edition 67 2012 Characterization of a reductively-activated elimination pathway relevant to the biological chemistry of the kinamycins and lomaiviticins Seth Herzon · Chem. Sci. 15 2012 Development of enantioselective synthetic routes to (–)-kinamycin F and (–)-lomaiviticin aglycon Seth Herzon · Journal of the American Chemical Society 44 2012 Isolation of lomaiviticins C-E. Transformation of lomaiviticin C to lomaiviticin A, complete structure elucidation of lomaiviticin A, and structure-activity analyses Seth Herzon · Journal of the American Chemical Society 75 2012 Real time kinetics of surfactant molecules transfer between emulsion particles probed by in situ second harmonic generation spectroscopy Seth Herzon · Journal of the American Chemical Society 33 2012 Regioselective reductive hydration of alkynes to form branched or linear alcohols Seth Herzon · Journal of the American Chemical Society 58 2012 Room temperature, palladium-mediated P–arylation of secondary phosphine oxides Seth Herzon · Organic Letters · needs review 113 2012 Synthesis of (R)-(+)-4-methyl-cyclohex-2-ene-1-one Seth Herzon · The Journal of Organic Chemistry 6 2012 The diazofluorene antitumor antibiotics: Structural elucidation, biosynthetic, synthetic, and chemical biological studies Seth Herzon · Nat. Prod. Rep. 81 2012 The kinamycins Seth Herzon · Total Synthesis of Natural Products 7 2012 The pharmacology and therapeutic potential of (–)-huperzine A Seth Herzon · Journal of Experimental Pharmacology 28