Publications

2026 Abstract PR001: Targeting S6K2 overcomes resistance to RAS inhibition in NRAS-mutant melanoma Jeffrey D. Winkler · Cancer Research · Scholar only — 2024 Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury Jeffrey D. Winkler · PLoS ONE · Scholar only 5 2023 Biliatresone treatment of pregnant mice causes changes in bile metabolism and liver inflammation in their offspring Jeffrey D. Winkler · BioRxiv, 2023.03 · Scholar only 4 2023 Lysosomal lipid peroxidation regulates tumor immunity Jeffrey D. Winkler · Journal of Clinical Investigation · Scholar only 66 2022 A novel class of dimeric quinacrine compounds induce DNA damage and increase the anticancer activity of radiation Jeffrey D. Winkler · Cancer Research · Scholar only — 2022 Bisaminoquinolines and bisaminoacridines compounds and methods of their use Jeffrey D. Winkler · US Patent App · Scholar only — 2022 Compositions and methods for inhibiting acss2 Jeffrey D. Winkler · US Patent App · Scholar only — 2022 Compounds, compositions and methods for prevention and/or treatment of cancer Jeffrey D. Winkler · US Patent 11,369 · Scholar only — 2022 Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation Jeffrey D. Winkler · Proceedings of the National Academy of Sciences · Scholar only 46 2021 Anticancer properties of bisaminoquinolines with modified linkers Jeffrey D. Winkler · Bioorganic & Medicinal Chemistry Letters · Scholar only 4 2021 Dimeric Quinacrine Derivatives As Autophagy Inhibitors For Cancer Therapy Jeffrey D. Winkler · US Patent App · Scholar only 10 2021 Synthesis of and Metal Complexation with a Chiral Cyclam Jeffrey D. Winkler · The Journal of Organic Chemistry · Scholar only 4 2021 Synthesis of the Core Ring System of the Antiosteoporotic Citrofulvicin Jeffrey D. Winkler · Organic Letters · Scholar only 1 2021 Targeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain Jeffrey D. Winkler · Bioorganic & Medicinal Chemistry Letters · Scholar only 2 2020 Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia Jeffrey D. Winkler · Gastroenterology · Scholar only 27 2020 PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma Jeffrey D. Winkler · JCI Insight · Scholar only · needs review 111 2020 SIRT1 is downregulated by autophagy in senescence and ageing Jeffrey D. Winkler · Nature Cell Biology · Scholar only 624 2020 Synthesis and Applications of the C2-Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane Jeffrey D. Winkler · The Journal of Organic Chemistry · Scholar only 5 2020 Synthesis of a novel bruceantin analog via intramolecular etherification Jeffrey D. Winkler · Canadian Journal of Chemistry · Scholar only 7 2020 Synthesis of Cyclohexane-Angularly-Fused Triquinanes Jeffrey D. Winkler · Synthesis · Scholar only 23 2020 Synthetic studies toward citrofulvicin Jeffrey D. Winkler · American Chemical Society SciMeetings · Scholar only · needs review — 2019 A 3-(4-nitronaphthen-1-yl) amino- benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics Jeffrey D. Winkler · The Journal of Steroid Biochemistry and Molecular Biology 33 2019 A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299 Jeffrey D. Winkler · International Journal of Molecular Sciences · Scholar only 40 2019 A Transannular Rearrangement Reaction of a Pyrroloindoline Diketopiperazine Jeffrey D. Winkler · Organic Letters · Scholar only 9 2019 PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer Jeffrey D. Winkler · Cancer Discovery 272 2019 Targeting quiescent leukemic stem cells using second generation autophagy inhibitors Jeffrey D. Winkler · Scholar only — 2019 Total Synthesis of Ingenol Jeffrey D. Winkler · Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules · Scholar only — 2018 A 3-(4-Nitronaphthen-1-yl) amino-benzoate analog as a Bifunctional AKR1C3 Inhibitor with AR Antagonist Activity: Head to Head Comparison with Other Advanced AKR1C3 Targeted … Jeffrey D. Winkler · Scholar only — 2018 Compositions and methods for increasing, or preventing or reversing loss of, skin pigmentation in a mammalian subject Jeffrey D. Winkler · US Patent App · Scholar only 2 2018 Design, Synthesis and Biological Evaluation of Allosteric Effectors that Enhance CO Release from Carboxyhemoglobin Jeffrey D. Winkler · ACS Medicinal Chemistry Letters 10 2018 Dimeric Quinacrines as Chemical Tools to Identify PPT1, a New Regulator of Autophagy Jeffrey D. Winkler · Molecular & Cellular Oncology 32 2018 Gilbert Stork Jeffrey D. Winkler · Ang. Chem. Int. Ed. — 2018 Leukemia, 2019, in press. DOI:10.1038/s41375-018-0252-4. Jeffrey D. Winkler · Leukemia 151 2018 N-(7-cyano-6-(4- fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2- yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF Through the Induction of Inhibited Dimers Jeffrey D. Winkler · Journal of Medicinal Chemistry 10 2018 N‑(7-Cyano-6-(4-fluoro-3-(2-(3-(tri 苯 luoro 衫 ethyl) 計 henyl) 苔 cet 苔 mido) 計 hen 觔 xy) 苑 enzo 茉 d] thi 苔 zol-2-yl) 苞 yclo 計 ro 計 ane 苞 arb 觔 x 苔 mide (TAK632 … Jeffrey D. Winkler · Journal of Medicinal Chemistry · Scholar only — 2018 Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia Jeffrey D. Winkler · ACS Medicinal Chemistry Letters 18 2017 ALDH1A1 and HLTF Modulate the Activity of Lysosomal Autophagy Inhibitors Jeffrey D. Winkler · Autophagy 41 2017 Asymmetric bisaminoquinolines and bisaminoquinolines with varied linkers as autophagy inhibitors for cancer and other therapy Jeffrey D. Winkler · US Patent App · Scholar only 10 2017 ATG5 Mediates a Positive Feedback Loop Between Wnt Signaling and Autophagy in Melanoma Jeffrey D. Winkler · Cancer Research 43 2017 A Unified Approach to Targeting the Lysosome’s Degradative and Growth Signal Notes Jeffrey D. Winkler · Cancer Discovery 222 2017 Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma Jeffrey D. Winkler · Molecular Cancer Research 78 2017 Autophagy Supports Generation of Cells with High CD44 Expression via Modulation of Oxidative Stress and Parkin-Mediated Mitochondrial Clearance Jeffrey D. Winkler · Oncogene 114 2017 CDK4/6 and Autophagy Inhibitors Synergistically Induce Senescence in Rb Positive Cytoplasmic Cyclic E Negative Cancers Jeffrey D. Winkler · Nature Communications 354 2017 Gilbert Stork (1921–2017) Jeffrey D. Winkler · Angewandte Chemie International Edition · Scholar only · needs review 5 2017 Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma Jeffrey D. Winkler · Radiology 60 2017 Studies directed towards the synthesis of a sparteine surrogate Jeffrey D. Winkler · ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · Scholar only — 2017 Synthesis of dimeric lysosomal inhibitors and their evaluation as anticancer agents Jeffrey D. Winkler · ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · Scholar only — 2017 Therapeutic agents Jeffrey D. Winkler · US Patent 9,540 · Scholar only 1 2016 Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof Jeffrey D. Winkler · US Patent 9,271 · Scholar only 3 2016 Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF/V600E Conformation Jeffrey D. Winkler · ACS Chemical Biology 46