Publications

2025 Effects of empagliflozin on quality of life and healthcare use and costs in chronic kidney disease: a health economic analysis of the EMPA-KIDNEY trial Megan L. Matthews · EClinicalMedicine · Scholar only 12 2025 Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome Megan L. Matthews · Cell metabolism 37 (1), 154-168. e7 · Scholar only 30 2025 Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma Megan L. Matthews · Science Advances · Scholar only 3 2025 Predicting hospitalization and related outcomes in advanced chronic kidney disease: A systematic review, external validation, and development study Megan L. Matthews · Kidney medicine · Scholar only 4 2024 Abstract 2232 Uncharacterized enzymes secernin2/3 and their novel cofactor glyoxylyl group regulate whole body sulfur metabolism Megan L. Matthews · Journal of Biological Chemistry · Scholar only — 2024 Activity-Based Protein Profiling of RHBDL4 Reveals Proteolysis of the Enzyme and a Distinct Inhibitor Profile Megan L. Matthews · ACS Chemical Biology · Scholar only 1 2024 Chemoproteomic Covalent Ligand Discovery as the PROTAC-gonist: The Future of Targeted Degradation Medicines Megan L. Matthews · ACS Central Science · Scholar only 2 2024 Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial Megan L. Matthews · The Lancet Diabetes & Endocrinology · Scholar only 123 2024 Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial Megan L. Matthews · The Lancet Diabetes & Endocrinology · Scholar only 145 2024 Protein phosphatase PP2Cα S-glutathionylation regulates cell migration Megan L. Matthews · Journal of Biological Chemistry · Scholar only 9 2023 Characterizing metabolic drivers of Clostridioides difficile Megan L. Matthews · Journal of Biological Chemistry · Scholar only · needs review — 2023 Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes Megan L. Matthews · Frontiers in Pharmacology · Scholar only · needs review 8 2023 Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration Megan L. Matthews · Cell chemical biology · Scholar only 17 2023 eCOVID-19 recommendations map collaborators. Good or best practice statements: Proposal for the operationalisation and implementation of GRADE guidance Megan L. Matthews · BMJ Evid Based Med · Scholar only 24 2023 Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception Megan L. Matthews · Molecular and Cellular Neuroscience · Scholar only 13 2022 Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications Megan L. Matthews · US Patent App · Scholar only 1 2022 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors Megan L. Matthews · Journal of the American Chemical Society · Scholar only 33 2022 Enterococci enhance Clostridioides difficile pathogenesis Megan L. Matthews · Nature · Scholar only 229 2022 Predicting kidney failure, cardiovascular disease and death in advanced CKD patients Megan L. Matthews · Kidney International Reports · Scholar only 21 2022 Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron(II)‐ and 2‐Oxoglutarate‐dependent Oxygenases Megan L. Matthews · The FASEB Journal · Scholar only — 2021 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets Megan L. Matthews · ACS Central Science · Scholar only 44 2021 Voices of chemical biology Megan L. Matthews · Nature Chemical Biology · Scholar only 2 2020 Discovery of Electrophiles and Profiling of Enzyme Cofactors Megan L. Matthews · Current Protocols in Chemical Biology · Scholar only 11 2020 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes Megan L. Matthews · bioRxiv, 2020.06 · Scholar only — 2020 Structural and molecular determinants of CCS-mediated copper activation of MEK1/2 Megan L. Matthews · BioRxiv, 2020.05 · Scholar only 4 2019 Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases Megan L. Matthews · Journal of the American Chemical Society · Scholar only 54 2018 Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical Megan L. Matthews · Proceedings of the National Academy of Sciences · Scholar only 76 2017 Chemoproteomic profiling and discovery of protein electrophiles in human cells. Megan L. Matthews · Nature Chemistry 108 2017 Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor. Megan L. Matthews · Journal of the American Chemical Society 39 2017 Vanadyl as a stable structural mimic of reactive ferryl intermediates in mononuclear non-heme-iron enzymes. Megan L. Matthews · Inorganic Chemistry 35 2016 Chemical proteomic profiling of human methyltransferases. Megan L. Matthews · Journal of the American Chemical Society 117 2016 Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity. Megan L. Matthews · Journal of the American Chemical Society 119 2015 2-Oxoglutarate-dependent oxygenases Megan L. Matthews · RSC Metallobiology · Scholar only 77 2015 Mechanisms of 2-oxoglutarate-dependent oxygenases: the hydroxylation paradigm and beyond Megan L. Matthews · 2-Oxoglutarate-Dependent Oxygenases 78 2014 Design of activated serine-containing catalytic triads with atomic-level accuracy. Megan L. Matthews · Nature Chemical Biology 111 2014 Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase. Megan L. Matthews · Nature Chemical Biology 192 2013 Aza-b-lactam compounds and methods of using Megan L. Matthews · WO 2013152272 A1 — 2013 Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2. Megan L. Matthews · Nature 301 2013 Elucidation of the iron (IV)–oxo intermediate in the non-haem iron halogenase SyrB2 Megan L. Matthews · Nature · Scholar only 4 2013 Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations. Megan L. Matthews · Coordination Chemistry Reviews 27 2012 Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Megan L. Matthews · Chemistry & Biology 257 2011 Protein control of dioxygen activation, substratehydrogen abstraction, and ligand-radical-transfer outcome in the aliphatic halogenase, SyrB2 Megan L. Matthews · The Pennsylvania State University · Scholar only 2 2010 How Aliphatic Halogenases Prevent Competing Hydroxylation: 43 Megan L. Matthews · Protein Science · Scholar only — 2010 Remote enzyme microsurgery. Megan L. Matthews · Science 8 2010 The nonribosomal peptide synthetase enzyme DdaD tethers N(b)-fumaramoyl-L-2,3-diaminopropionate for Fe(II)/a-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. Megan L. Matthews · Journal of the American Chemical Society 47 2010 The NRPS enzyme DdaD tethers Nβ-fumaramoyl-DAP for Fe (II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis Megan L. Matthews · Journal of the American Chemical Society · Scholar only 3 2009 Myo-inositol oxygenase: a radical new pathway for O2 and C-H activation at a nonheme diiron cluster. Megan L. Matthews · Dalton Trans. 72 2009 Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. Megan L. Matthews · Proceedings of the National Academy of Sciences 291 2009 Substrate-triggered formation and remarkable stability of the C–H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. Megan L. Matthews · Biochemistry 300 2007 AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases. Megan L. Matthews · Biochemistry 51