Publications

2021 Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites David W. Christianson · Nature Communications · Scholar only 115 2019 Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases David W. Christianson · Current opinion in structural biology · Scholar only 168 2019 Synthesis and biological investigation of phenothiazine-based benzhydroxamic acids as selective histone deacetylase 6 inhibitors David W. Christianson · Journal of medicinal chemistry · Scholar only 118 2018 Histone deacetylase 6-selective inhibitors and the influence of capping groups on hydroxamate-zinc denticity David W. Christianson · Journal of medicinal chemistry · Scholar only 116 2017 ARID1A-mutated ovarian cancers depend on HDAC6 activity David W. Christianson · Nature cell biology · Scholar only 271 2017 Histone deacetylase 10 structure and molecular function as a polyamine deacetylase David W. Christianson · Nature communications · Scholar only 233 2017 Structural and chemical biology of terpenoid cyclases David W. Christianson · Chemical reviews · Scholar only 1,406 2017 Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors David W. Christianson · Proceedings of the National Academy of Sciences · Scholar only 210 2016 Histone deacetylase 6 structure and molecular basis of catalysis and inhibition David W. Christianson · Nature chemical biology · Scholar only 606 2014 Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked … David W. Christianson · Human molecular genetics · Scholar only 215 2013 Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections David W. Christianson · Archives of biochemistry and biophysics · Scholar only 104 2013 Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant … David W. Christianson · Journal of medicinal chemistry · Scholar only 131 2012 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle David W. Christianson · Nature · Scholar only 748 2011 Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases David W. Christianson · Journal of the American Chemical Society · Scholar only 200 2011 Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase David W. Christianson · Nature chemical biology · Scholar only 218 2011 Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes David W. Christianson · Current opinion in structural biology · Scholar only 381 2011 Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis David W. Christianson · Nature · Scholar only 426 2010 Arginase I suppresses IL-12/IL-23p40–driven intestinal inflammation during acute schistosomiasis David W. Christianson · The Journal of immunology · Scholar only 168 2010 Structure of epi-isozizaene synthase from Streptomyces coelicolor A3 (2), a platform for new terpenoid cyclization templates David W. Christianson · Biochemistry · Scholar only 188 2010 Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission David W. Christianson · Journal of molecular biology · Scholar only 136 2010 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function David W. Christianson · Biochemistry · Scholar only 103 2010 Trinuclear metal clusters in catalysis by terpenoid synthases David W. Christianson · Pure and applied chemistry. Chimie pure et appliquee · Scholar only 172 2009 Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats David W. Christianson · Journal of applied physiology · Scholar only 313 2009 Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase David W. Christianson · Journal of the American Chemical Society · Scholar only 186 2009 Crystal structure of (+)-δ-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis David W. Christianson · Biochemistry · Scholar only 139 2008 Arginase and vascular aging David W. Christianson · Journal of applied physiology · Scholar only 219 2008 Directing noble metal ion chemistry within a designed ferritin protein David W. Christianson · Biochemistry · Scholar only 132 2008 Endothelial arginase II: a novel target for the treatment of atherosclerosis David W. Christianson · Circulation research · Scholar only 304 2008 Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors, David W. Christianson · Biochemistry · Scholar only 251 2008 Unearthing the roots of the terpenome David W. Christianson · Current opinion in chemical biology · Scholar only 389 2007 Inducible NO Synthase–Dependent S-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction David W. Christianson · Circulation research · Scholar only 252 2007 Roots of biosynthetic diversity David W. Christianson · Science · Scholar only 132 2007 X-ray crystal structure of aristolochene synthase from Aspergillus terreus and the evolution of templates for the cyclization of farnesyl diphosphate David W. Christianson · Biochemistry · Scholar only 178 2006 Human soluble epoxide hydrolase: Structural basis of inhibition by 4‐(3‐cyclohexylureido)‐carboxylic acids David W. Christianson · Protein science · Scholar only 130 2006 Structural biology and chemistry of the terpenoid cyclases David W. Christianson · Chemical reviews · Scholar only 955 2006 Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with “two-prong” inhibitors reveal the molecular basis of high affinity David W. Christianson · Journal of the American Chemical Society · Scholar only 108 2005 Arginase: structure, mechanism, and physiological role in male and female sexual arousal David W. Christianson · Accounts of chemical research · Scholar only 196 2005 Crystal structure of human arginase I at 1.29-Å resolution and exploration of inhibition in the immune response David W. Christianson · Proceedings of the National Academy of Sciences · Scholar only 237 2004 Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV David W. Christianson · J Biol Chem · Scholar only 143 2004 Structure of Human Epoxide Hydrolase Reveals Mechanistic Inferences on Bifunctional Catalysis in Epoxide and Phosphate Ester Hydrolysis, David W. Christianson · Biochemistry · Scholar only 238 2003 Arginase and autoimmune inflammation in the central nervous system David W. Christianson · Immunology · Scholar only 119 2003 Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis David W. Christianson · Proceedings of the National Academy of Sciences · Scholar only 205 2003 Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal, David W. Christianson · Biochemistry · Scholar only 193 2002 Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase David W. Christianson · Proceedings of the National Academy of Sciences · Scholar only 419 2002 Combinatorial computational method gives new picomolar ligands for a known enzyme David W. Christianson · Proceedings of the National Academy of Sciences · Scholar only 123 2002 Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle David W. Christianson · Biochemistry · Scholar only 116 2002 Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis David W. Christianson · Journal of the American Chemical Society · Scholar only 200 2002 X-ray Crystal Structures of D100E Trichodiene Synthase and Its Pyrophosphate Complex Reveal the Basis for Terpene Product Diversity, David W. Christianson · Biochemistry · Scholar only 107 2001 Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells David W. Christianson · Proceedings of the National Academy of Sciences · Scholar only 440 2001 Fluoroaromatic− Fluoroaromatic Interactions between Inhibitors Bound in the Crystal Lattice of Human Carbonic Anhydrase II David W. Christianson · Journal of the American Chemical Society · Scholar only 106