Publications

2025 Deep mutational scanning of FDX1 identifies key structural determinants of lipoylation and cuproptosis Squire J. Booker · Nature communications · Scholar only 26 2023 Enzymatic fluoromethylation enabled by the S-adenosylmethionine analog Te-adenosyl-L-(fluoromethyl) homotellurocysteine Squire J. Booker · ACS Central Science · Scholar only 36 2023 FDX1 regulates cellular protein lipoylation through direct binding to LIAS Squire J. Booker · Journal of Biological Chemistry · Scholar only 258 2023 Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2 Squire J. Booker · Nature chemical biology · Scholar only 185 2023 How synonymous mutations alter enzyme structure and function over long timescales Squire J. Booker · Nature Chemistry · Scholar only 101 2022 Discovery, structure and mechanism of a tetraether lipid synthase Squire J. Booker · Nature · Scholar only 106 2022 [FeFe]‐Hydrogenase: Defined Lysate‐Free Maturation Reveals a Key Role for Lipoyl‐H‐Protein in DTMA Ligand Biosynthesis Squire J. Booker · Angewandte Chemie · Scholar only 30 2022 In vitro demonstration of human lipoyl synthase catalytic activity in the presence of NFU1 Squire J. Booker · ACS bio & med Chem Au · Scholar only 28 2022 Methods in Enzymology; Using peptide substrate analogs to characterize a radical intermediate in NosN catalysis Squire J. Booker · Elsevier · Scholar only 204 2022 Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis Squire J. Booker · Nature · Scholar only 67 2022 Twenty years of radical SAM! The genesis of the superfamily Squire J. Booker · ACS bio & med Chem Au · Scholar only 61 2021 Structural basis for non-radical catalysis by TsrM, a radical SAM methylase Squire J. Booker · Nature chemical biology · Scholar only 74 2021 Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB Squire J. Booker · Nature · Scholar only 60 2020 First Step in Catalysis of the Radical S‑Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S] 0‑Like Auxiliary Cluster Squire J. Booker · Journal of the American Chemical Society · Scholar only 34 2019 Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side Ring System Squire J. Booker · Journal of the American Chemical Society · Scholar only 32 2019 Ferredoxins as interchangeable redox components in support of MiaB, a radical S‐adenosylmethionine methylthiotransferase Squire J. Booker · Protein Science · Scholar only 29 2019 Methanogenesis marker protein 10 (Mmp10) from Methanosarcina acetivorans is a radical S-adenosylmethionine methylase that unexpectedly requires cobalamin Squire J. Booker · Journal of Biological Chemistry · Scholar only 56 2019 Parsing redox potentials of five ferredoxins found within Thermotoga maritima Squire J. Booker · Protein Science · Scholar only 22 2019 Stuffed methyltransferase catalyzes the penultimate step of pyochelin biosynthesis Squire J. Booker · Biochemistry · Scholar only 21 2019 The A-type domain in Escherichia coli NfuA is required for regenerating the auxiliary [4Fe–4S] cluster in Escherichia coli lipoyl synthase Squire J. Booker · Journal of Biological Chemistry · Scholar only 38 2019 Understanding the role of electron donors in the reaction catalyzed by Tsrm, a cobalamin-dependent radical S-adenosylmethionine methylase Squire J. Booker · JBIC Journal of Biological Inorganic Chemistry · Scholar only 19 2018 Atlas of the radical SAM superfamily: divergent evolution of function using a “plug & play” domain Squire J. Booker · Methods in enzymology · Scholar only 158 2018 Biochemical approaches for understanding iron-sulfur cluster regeneration in Escherichia coli lipoyl synthase during catalysis Squire J. Booker · Methods in enzymology · Scholar only 31 2018 Enhanced Solubilization of Class B Radical S‑Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli Squire J. Booker · Biochemistry · Scholar only 109 2018 Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from Streptomyces fradiae, a Cobalamin-Dependent Radical S‑Adenosylmethionine Methylase Squire J. Booker · Biochemistry · Scholar only 43 2017 Destruction and reformation of an iron-sulfur cluster during catalysis by lipoyl synthase Squire J. Booker · Science · Scholar only 156 2017 Efficient methylation of C2 in L-tryptophan by the cobalamin-dependent radical S-adenosylmethionine methylase TsrM requires an unmodified N1 amine Squire J. Booker · Journal of Biological Chemistry · Scholar only 39 2017 Rerouting the pathway for the biosynthesis of the side ring system of nosiheptide: the roles of NosI, NosJ, and NosK Squire J. Booker · Journal of the American Chemical Society · Scholar only 39 2017 The Radical S-Adenosylmethionine Methylase NosN Catalyzes Both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide Squire J. Booker · Journal of the American Chemical Society · Scholar only 66 2017 TsrM as a model for purifying and characterizing cobalamin-dependent radical S-adenosylmethionine methylases Squire J. Booker · Methods in enzymology · Scholar only 38 2016 Characterization of Lipoyl Synthase from Mycobacterium tuberculosis Squire J. Booker · Biochemistry · Scholar only 26 2016 Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA Squire J. Booker · Science · Scholar only 84 2016 Crystallographic snapshots of sulfur insertion by lipoyl synthase Squire J. Booker · Proceedings of the National Academy of Sciences · Scholar only 135 2016 Radical S-Adenosylmethionine Enzymes in Human Health and Disease Squire J. Booker · Annual review of biochemistry · Scholar only 263 2016 Spectroscopic and Electrochemical Characterization of the Iron–Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase Squire J. Booker · Journal of the American Chemical Society · Scholar only 105 2016 Stereochemical course of the reaction catalyzed by RimO, a radical SAM methylthiotransferase Squire J. Booker · Journal of the American Chemical Society · Scholar only 17 2016 Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid Squire J. Booker · Journal of the American Chemical Society · Scholar only 19 2016 Transformations of the FeS clusters of the methylthiotransferases MiaB and RimO, detected by direct electrochemistry Squire J. Booker · Biochemistry · Scholar only 22 2016 Trifluoroselenomethionine: A new unnatural amino acid Squire J. Booker · ChemBioChem · Scholar only 48 2015 Auxiliary iron–sulfur cofactors in radical SAM enzymes Squire J. Booker · Biochimica et Biophysica Acta (BBA)-Molecular Cell Research · Scholar only 153 2015 Characterization of a radical intermediate in lipoyl cofactor biosynthesis Squire J. Booker · Journal of the American Chemical Society · Scholar only 37 2015 Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis Squire J. Booker · Proceedings of the National Academy of Sciences · Scholar only 108 2015 Efficient Delivery of Long-Chain Fatty Aldehydes from the Nostoc punctiforme Acyl–Acyl Carrier Protein Reductase to Its Cognate Aldehyde-Deformylating Oxygenase Squire J. Booker · Biochemistry · Scholar only 52 2015 Electrochemical resolution of the [4Fe-4S] centers of the AdoMet radical enzyme BtrN: evidence of proton coupling and an unusual, low-potential auxiliary cluster Squire J. Booker · Journal of the American Chemical Society · Scholar only 58 2015 Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation Squire J. Booker · Journal of Biological Chemistry · Scholar only 293 2015 Mössbauer spectroscopy of Fe/S proteins Squire J. Booker · Biochimica et Biophysica Acta (BBA)-Molecular Cell Research · Scholar only 173 2015 Rapid reduction of the diferric-peroxyhemiacetal intermediate in aldehyde-deformylating oxygenase by a cyanobacterial ferredoxin: evidence for a free-radical mechanism Squire J. Booker · Journal of the American Chemical Society · Scholar only 78 2014 Characterization of a cross-linked protein–nucleic acid substrate radical in the reaction catalyzed by RlmN Squire J. Booker · Journal of the American Chemical Society · Scholar only 56 2014 Evidence for a catalytically and kinetically competent enzyme–substrate cross-linked intermediate in catalysis by lipoyl synthase Squire J. Booker · Biochemistry · Scholar only 70 2014 Iron-sulfur clusters in chemistry and biology Squire J. Booker · Walter de Gruyter GmbH & Co KG · Scholar only 59