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Publications

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2026 A Combinatorial Synthetic Strategy for Developing Genome-Editing Protein-Delivery Agents Targeting Mouse Retina David R. Liu · Nature Communications 2026 AI-guided Re-design of Laboratory-Evolved Reverse Transcriptases Enhances Prime Editing in Human Cells and in Animals David R. Liu · Nature Biotechnology 3 2026 AI-redesigned Starting Points and Outcomes Enhance Protein Evolution David R. Liu · Nature 2026 Directed Evolution of Small RNA-Stabilizing Motifs that Improve Prime Editing David R. Liu · Nature Biotechnology 2026 Efficient Prime Editing In Vivo and In Vitro Using Lipid Nanoparticles David R. Liu · Nature Nanotechnology 2026 Evolution of Botulinum Neurotoxin Serotype X Proteases to Induce Inflammatory Cell Death in Cancer Cells David R. Liu · Nature Biotechnology 2026 In Vivo Adenine Base Editing Ameliorates Dravet Syndrome Phenotypes in a Mouse Model David R. Liu · Science Translational Medicine 2026 In Vivo Base Editing Rescues Liver Pathophysiology and Peroxisome Dysfunction in a Mouse Model of Zellweger Spectrum Disorder David R. Liu · Nature Biomedical Engineering 2026 Mechanistic Machine Learning for Prediction of Prime Editing Outcomes David R. Liu · Nature Biotechnology 2026 Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model David R. Liu · Molecular Therapy 2026 Small-Molecule Binding and Sensing with a Designed Protein Family David R. Liu · Nature Communications 2026 Synonymous Editing Alters Ion Channel Function, Favoring Prime Editing for Retinal Disease Correction David R. Liu · International Journal of Biological Sciences 2026 Virus-like Particles Enable Targeted Gene Engineering and Pooled CRISPR Screening in Primary Human Myeloid Cells David R. Liu · Nature Biotechnology 2025 Adenine Base Editing Rescues Pathogenic Phenotypes in Tissue Engineered Vascular Model of Hutchinson-Gilford Progeria Syndrome David R. Liu · APL Bioengineering 2025 A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies David R. Liu · Journal of the American Chemical Society 2025 Branched, Chemically Modified Poly(A) Tails Enhance the Translation Capacity of mRNA David R. Liu · Nature Biotechnology 2025 Correcting a Pathogenic Mitochondrial DNA Mutation by Base Editing in Mice David R. Liu · Science Translational Medicine 2025 Directed Evolution of Engineered Virus-Like Particles with Improved Production and Transduction Efficiencies David R. Liu · Nature Biotechnology 2025 Efficient Site-Specific Integration of Large Genes in Mammalian Cells Via Continuously Evolved Recombinases and Prime Editing David R. Liu · Nature Biomedical Engineering 2025 Engraftment and Persistence of HBB Base-Edited Hematopoietic Stem Cells in Nonhuman Primates David R. Liu · Science Translational Medicine 2025 EvoAI Enables Extreme Compression and Reconstruction of the Protein Sequence Space David R. Liu · Nature Methods 2025 GFP-on Mouse Model for Interrogation of In Vivo Gene Editing David R. Liu · Nature Communications 2025 High Throughput Evaluation of Genetic Variants with Prime Editing Sensor Libraries David R. Liu · Nature Biotechnology 2025 In Vivo Base Editing Extends Lifespan of a Humanized Mouse Model of Prion Disease David R. Liu · Nature Medicine 2025 In Vivo Base Editing of Angptl3 via Lipid Nanoparticles to Treat Cardiovascular Disease David R. Liu · Molecular Therapy Nucleic Acids 2025 In Vivo Prime Editing Rescues Alternating Hemiplegia of Childhood in Mice David R. Liu · Cell 2025 In Vivo Prime Editing Rescues Photoreceptor Degeneration in Nonsense Mutant Retinitis Pigmentosa David R. Liu · Nature Communications 2025 Modulating Collagen I Expression in Fibroblasts by CRISPR-Cas9 Base Editing of the Collagen 1A1 Promoter David R. Liu · International Journal of Molecular Sciences 2025 Multiplex Base Editing to Protect from CD33 Directed Drugs for Immune and Gene Therapy David R. Liu · Nature Communications 2025 Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease David R. Liu · New England Journal of Medicine 441 2025 Precisely Defining Disease Variant Effects in CRISPR-Edited Single Cells David R. Liu · Nature 2025 Prime Editing-Installed Suppressor tRNAs for Disease-Agnostic Genome Editing David R. Liu · Nature 2025 Programmable Gene Insertion in Human Cells with a Laboratory-Evolved CRISPR-Associated Transposase David R. Liu · Science 2025 Safer and Efficient Base Editing and Prime Editing Via Ribonucleoproteins Delivered Through Optimized Lipid-Nanoparticle Formulations David R. Liu · Nature Biomedical Engineering 2025 Scalable Purification Enables High-Quality Virus-Like Particles for Therapeutic Translation David R. Liu · Journal of Biological Chemistry 2025 Systematic Empirical Evaluation of Individual Base Editing Targets: Validating Therapeutic Targets in USH2A and Comparison of Methods David R. Liu · Molecular Therapy 2025 Systematic Optimization of Prime Editing for the Efficient Functional Correction of CFTR F508del in Human Airway Epithelial Cells David R. Liu · Nature Biomedical Engineering 2025 TIGER: A Novel tdTomato In-Vivo Genome-Editing Reporter Mouse for Investigating Precision-Editor Delivery Approaches David R. Liu · Proceedings of the National Academy of Sciences 2025 Ultrasmall Chemogenetic Tags with Group-Transfer Ligands David R. Liu · Angewandte Chemie International Edition 2024 Adenine Transversion Editors Enable Precise, Efficient A•T-To-C•G Base Editing in Mammalian Cells and Embryos David R. Liu · Nature Biotechnology 2024 Amphiphilic Shuttle Peptide Delivers Base Editor Ribonucleoprotein to Correct the CFTR R553X Mutation in Well-Differentiated Airway Epithelial Cells David R. Liu · Nucleic Acids Research 2024 A Prime Editor Mouse to Model a Broad Spectrum of Somatic Mutations In Vivo David R. Liu · Nature Biotechnology 2024 Bone Marrow Homing Lipid Nanoparticles for Genome Editing in Diseased and Malignant Hematopoietic Stem Cells David R. Liu · Nature Nanotechnology 2024 Continuous Evolution of Compact Protein Degradation Tags Regulated by Selective Cereblon Molecular Glues David R. Liu · Science 2024 Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours David R. Liu · Nature Reviews Cancer · Scholar only 341 2024 Efficient Prime Editing in Mouse Brain, Liver and Heart with Dual AAVs David R. Liu · Nature Biotechnology 2024 Efficient Prime Editing in Two-Cell Mouse Embryos Using PEmbryo David R. Liu · Nature Biotechnology 2024 Engineered Virus-Like Particles for Transient Delivery of Prime Editor Ribonucleoprotein Complexes In Vivo David R. Liu · Nature Biotechnology 2024 Introducing a Hemoglobin G-Makassar Variant in HSCs by In Vivo Base Editing Treats Sickle Cell Disease in Mice David R. Liu · Molecular Therapy 2024 In Vivo Photoreceptor Base Editing Ameliorates Rhodopsin-E150K Autosomal-Recessive Retinitis Pigmentosa in Mice David R. Liu · Proceedings of the National Academy of Sciences
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2026 · article · journal

A Combinatorial Synthetic Strategy for Developing Genome-Editing Protein-Delivery Agents Targeting Mouse Retina

Nature Communications · David R. Liu

in CV
noneScholar citations
noneOpenAlex citations

From the CV

lines 1608–1611 · published

300. "A Combinatorial Synthetic Strategy for Developing Genome-Editing Protein-Delivery Agents TargetingMouse Retina" Palczewski, K; Tochtrop, G.; Zhang, J.; Šmidák, R.; Du, S.; Holubowicz, S.; Felgner, P.;Felgner, J.; Palczewska, G.; Menezes, C.; Risaliti, E.; Holubowicz,, M.; Hu, Y.; Shayegan, M.; Li, B.; Chen,P.; Liu, D.R.; Xing, L.; Dong, Z.; Ma, X. Nature Communications, in press, available online (2026).

Peer reviewed
yes
First author
Palczewski
Co-authors
Palczewski, K; Tochtrop, G.; Zhang, J.; Šmidák, R.; Du, S.; Holubowicz, S.; Felgner, P.; Felgner, J.; Palczewska, G.; Menezes, C.; Risaliti, E.; Holubowicz,, M.; Hu, Y.; Shayegan, M.; Li, B.; Chen, P.; Liu, D.R.; Xing, L.; Dong, Z.; Ma, X.
Subfield
other
Method
none
Invited
none
Publisher
none
Reprint or translation
none
DOI
10.1038/s41467-026-69077-w

Where each field came from

FieldCVOpenAlexScholar
title A Combinatorial Synthetic Strategy for Developing Genome-Editing Protein-Delivery Agents Targeting Mouse Retina (used)
year 2026 (used)
venue Nature Communications (used)
kind article (used)
DOI 10.1038/s41467-026-69077-w (used)
first author Palczewski (used)

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