Publications

2024 Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies Joshua Rabinowitz · Science 385 (6711), eabm6131 · Scholar only 250 2023 Slow TCA flux and ATP production in primary solid tumours but not metastases Joshua Rabinowitz · Nature · Scholar only 331 2023 The pentose phosphate pathway in health and disease Joshua Rabinowitz · Nature metabolism · Scholar only 725 2021 Metabolite discovery through global annotation of untargeted metabolomics data Joshua Rabinowitz · Nature methods · Scholar only 317 2021 Restoring metabolism of myeloid cells reverses cognitive decline in ageing Joshua Rabinowitz · Nature · Scholar only 555 2021 The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine Joshua Rabinowitz · Cell metabolism 33 (5), 905-922. e6 · Scholar only 463 2020 A dual-mechanism antibiotic kills gram-negative bacteria and avoids drug resistance Joshua Rabinowitz · Cell 181 (7), 1518-1532. e14 · Scholar only 393 2020 A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway Joshua Rabinowitz · Nature chemical biology · Scholar only 234 2020 CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels Joshua Rabinowitz · Nature metabolism · Scholar only 406 2020 Comprehensive quantification of fuel use by the failing and nonfailing human heart Joshua Rabinowitz · Science · Scholar only 650 2020 Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate Joshua Rabinowitz · Nature · Scholar only 613 2020 Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity Joshua Rabinowitz · Proceedings of the National Academy of Sciences · Scholar only 254 2020 Lactate: the ugly duckling of energy metabolism Joshua Rabinowitz · Nature metabolism · Scholar only 1,257 2020 Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity Joshua Rabinowitz · Cell 183 (7), 1848-1866. e26 · Scholar only 831 2020 Quantitative fluxomics of circulating metabolites Joshua Rabinowitz · Cell metabolism 32 (4), 676-688. e4 · Scholar only 325 2020 Serine catabolism feeds NADH when respiration is impaired Joshua Rabinowitz · Cell metabolism 31 (4), 809-821. e6 · Scholar only 250 2020 SLC25A51 is a mammalian mitochondrial NAD+ transporter Joshua Rabinowitz · Nature · Scholar only 364 2019 A PRDM16-driven metabolic signal from adipocytes regulates precursor cell fate Joshua Rabinowitz · Cell metabolism 30 (1), 174-189. e5 · Scholar only 255 2019 Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function Joshua Rabinowitz · Nature · Scholar only 299 2019 Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation Joshua Rabinowitz · Nature immunology · Scholar only 545 2019 Metabolite exchange between mammalian organs quantified in pigs Joshua Rabinowitz · Cell metabolism 30 (3), 594-606. e3 · Scholar only 303 2019 NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism Joshua Rabinowitz · Nature metabolism · Scholar only 468 2019 Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids Joshua Rabinowitz · Cell metabolism 29 (2), 417-429. e4 · Scholar only 594 2019 Serine metabolism supports macrophage IL-1β production Joshua Rabinowitz · Cell metabolism 29 (4), 1003-1011. e4 · Scholar only 403 2019 T cell activation depends on extracellular alanine Joshua Rabinowitz · Cell reports 28 (12), 3011-3021. e4 · Scholar only 237 2019 The tumor metabolic microenvironment: lessons from lactate Joshua Rabinowitz · Cancer Research · Scholar only 261 2018 As extracellular glutamine levels decline, asparagine becomes an essential amino acid Joshua Rabinowitz · Cell metabolism 27 (2), 428-438. e5 · Scholar only 415 2018 Autophagy maintains tumour growth through circulating arginine Joshua Rabinowitz · Nature · Scholar only 374 2018 Extraction and quantitation of nicotinamide adenine dinucleotide redox cofactors Joshua Rabinowitz · Antioxidants & redox signaling · Scholar only 234 2018 Four key steps control glycolytic flux in mammalian cells Joshua Rabinowitz · Cell systems 7 (1), 49-62. e8 · Scholar only 467 2018 Metabolomics and isotope tracing Joshua Rabinowitz · Cell · Scholar only 1,045 2018 Mitochondrial translation requires folate-dependent tRNA methylation Joshua Rabinowitz · Nature · Scholar only 316 2018 Quantitative analysis of NAD synthesis-breakdown fluxes Joshua Rabinowitz · Cell metabolism 27 (5), 1067-1080. e5 · Scholar only 659 2018 The small intestine converts dietary fructose into glucose and organic acids Joshua Rabinowitz · Cell metabolism 27 (2), 351-361. e3 · Scholar only 787 2017 Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors Joshua Rabinowitz · Nature medicine · Scholar only 387 2017 Enhancing CD8+ T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapy Joshua Rabinowitz · Cancer cell 32 (3), 377-391. e9 · Scholar only 706 2017 Glucose feeds the TCA cycle via circulating lactate Joshua Rabinowitz · Nature · Scholar only 1,978 2017 Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma Joshua Rabinowitz · Proceedings of the National Academy of Sciences · Scholar only 303 2017 Metabolite measurement: pitfalls to avoid and practices to follow Joshua Rabinowitz · Annual review of biochemistry · Scholar only 601 2017 Metabolite spectral accuracy on orbitraps Joshua Rabinowitz · Analytical chemistry · Scholar only 331 2017 One-carbon metabolism in health and disease Joshua Rabinowitz · Cell metabolism · Scholar only 2,649 2017 Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling Joshua Rabinowitz · Cell 171 (7), 1545-1558. e18 · Scholar only 273 2016 A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance Joshua Rabinowitz · Nature medicine · Scholar only 712 2016 Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells Joshua Rabinowitz · Genes & development · Scholar only 440 2016 Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production Joshua Rabinowitz · Cell metabolism · Scholar only 350 2016 Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle Joshua Rabinowitz · Cell metabolism · Scholar only 439 2016 Metabolic control of methylation and acetylation Joshua Rabinowitz · Current opinion in chemical biology · Scholar only 354 2016 Metabolite concentrations, fluxes and free energies imply efficient enzyme usage Joshua Rabinowitz · Nature chemical biology · Scholar only 548 2016 Mitochondria and cancer Joshua Rabinowitz · Molecular cell · Scholar only 1,491 2016 Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation Joshua Rabinowitz · Cell metabolism · Scholar only 521