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2026 A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition Brian Liau · RSC Chemical Biology · Scholar only 2026 A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer Brian Liau · Genes & Development · Scholar only 2026 Developing COUPLrs, dual-warhead cysteine-reactive compounds, to target oncoproteins through interaction modulation and degradation Brian Liau · Cancer Research · Scholar only 2026 Nanoscaled, fully automated hydrogen/deuterium exchange for analysis of macromolecular assemblies reaching the MDa scale Brian Liau · Molecular & Cellular Proteomics · Scholar only 5 2026 Oxidized protein states define metastatic fitness in lung cancer Brian Liau · bioRxiv, 2026.06 · Scholar only 2026 Proximity-induced rewiring of oncogenic kinase triggers apoptosis Brian Liau · ACS Central Science · Scholar only 2 2026 Systematic targeting of protein complexes with molecular COUPLrs Brian Liau · Cancer discovery · Scholar only 3 2025 Abstract C019: Prime editing of DNMT3A to assess mutants rescuing the R882H hotspot mutation Brian Liau · Molecular Cancer Therapeutics · Scholar only 2025 Building the first base editors: Genome editing Brian Liau · nature chemical biology · Scholar only 1 2025 Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations Brian Liau · Nature · Scholar only 54 2025 Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase Brian Liau · Nature methods · Scholar only 10 2025 COuPLrs, a new class of cysteine-reactive compounds for modulating protein-protein interaction Brian Liau · Cancer Research · Scholar only 2025 Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance Brian Liau · Nature Communications · Scholar only 7 2025 CTCF/RAD21 organize the ground state of chromatin–nuclear speckle association Brian Liau · Nature structural & molecular biology · Scholar only 20 2025 DNA methylation insulates genic regions from CTCF loops near nuclear speckles Brian Liau · Elife · Scholar only 18 2025 Genetic landscape of DNMT3A R882H reveals mechanism of aberrant oligomerization Brian Liau · bioRxiv, 2025.09 · Scholar only 3 2025 Nanogram-scale HDX-MS enables structural analysis of sample-limited protein complexes Brian Liau · MOLECULAR & CELLULAR PROTEOMICS · Scholar only 2025 Oxidation of retromer complex controls mitochondrial translation Brian Liau · Nature · Scholar only 41 2025 Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis Brian Liau · bioRxiv · Scholar only 1 2025 Research briefing Brian Liau · Nature Methods · Scholar only 2025 UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors Brian Liau · Nature · Scholar only 65 2025 Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1 Brian Liau · Nature chemical biology · Scholar only 19 2024 An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing Brian Liau · Molecular cell 84 (12), 2238-2254. e11 · Scholar only 22 2024 Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes Brian Liau · bioRxiv, 2024.05 · Scholar only 2 2024 Compositions and methods for treating drug-tolerant glioblastoma Brian Liau · US Patent 11,998 · Scholar only 5 2024 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability Brian Liau · Cell 187 (10), 2536-2556. e30 · Scholar only 110 2024 KBTBD4 cancer hotspot mutations drive neomorphic degradation of HDAC1/2 corepressor complexes Brian Liau · bioRxiv, 2024.05 · Scholar only 4 2023 Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery Brian Liau · Elife · Scholar only 23 2023 Base editor scanning charts the DNMT3A activity landscape Brian Liau · Nature chemical biology · Scholar only 63 2023 Base editor scanning reveals activating mutations of DNMT3A Brian Liau · ACS chemical biology · Scholar only 12 2023 Base editor screens for in situ mutational scanning at scale Brian Liau · Molecular cell · Scholar only 49 2023 Chromatin complex dependencies reveal targeting opportunities in leukemia Brian Liau · Nature Communications · Scholar only 17 2023 CTCF/cohesin organize the ground state of chromatin-nuclear speckle association Brian Liau · bioRxiv, 2023.07 · Scholar only 7 2023 Differentiation of Acute Myeloid Leukemia Cells upon Pharmacological Inhibition of LSD1 Requires Its N-Terminal Intrinsically Disordered Region Brian Liau · Blood · Scholar only 2023 Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma Brian Liau · Nature chemical biology · Scholar only 23 2023 Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway Brian Liau · bioRxiv, 2023.03 · Scholar only 2023 Probing regulatory mechanisms of the de novo DNA methyltransferase DNMT3A Brian Liau · Biophysical Journal · Scholar only 2023 Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway Brian Liau · Cell 186 (11), 2361-2379. e25 · Scholar only 159 2022 CRISPR‐Suppressor scanning for systematic discovery of drug‐resistance mutations Brian Liau · Current protocols · Scholar only 11 2022 Drug addiction mutations unveil a methylation ceiling in EZH2-mutant lymphoma Brian Liau · bioRxiv, 2022.04 · Scholar only 3 2022 Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery Brian Liau · Nature Communications · Scholar only 53 2022 Profiling the landscape of drug resistance mutations in neosubstrates to molecular glue degraders Brian Liau · ACS Central Science · Scholar only 67 2021 Discovering new biology with drug-resistance alleles Brian Liau · Nature chemical biology · Scholar only 31 2021 Discovery of C13-aminobenzoyl cycloheximide derivatives that potently inhibit translation elongation Brian Liau · Journal of the American Chemical Society · Scholar only 10 2020 Gain-of-function genetic alterations of G9a drive oncogenesis Brian Liau · Cancer discovery · Scholar only 79 2019 CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML Brian Liau · Nature chemical biology · Scholar only 123 2019 Taking a STAP at Core Promoter–Transcriptional Cofactor Specificity Brian Liau · Biochemistry · Scholar only 2019 Versatile synthetic route to cycloheximide and analogues that potently inhibit translation elongation Brian Liau · Angewandte Chemie · Scholar only 33 2018 Cortistatin analogues and syntheses and uses thereof Brian Liau · US Patent 9,994 · Scholar only 2 2017 Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance Brian Liau · Cell stem cell 20 (2), 233-246. e7 · Scholar only 647
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2026 · article · journal

A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition

RSC Chemical Biology · Brian Liau

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FieldCVOpenAlexScholar
title A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition (used)
year 2026 (used)
venue RSC Chemical Biology (used)
kind other (used)
first author Barta (used)

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