Publications

2026 A bis-phosphorylated peptide wrangles the SHP2 tandem SH2 domains into shape Neel H. Shah · Structure · Scholar only — 2026 A scalable design for proximity-inducing molecules Neel H. Shah · Biorxiv · Scholar only 4 2026 Combinatorial Deep Mutational Scanning Uncovers Protein Superbinders and Molecular Determinants of Epistasis Neel H. Shah · Cell Press · Scholar only — 2026 Identification of substrates of the protein tyrosine phosphatase PTP1B using in situ site-specific photo-crosslinking Neel H. Shah · bioRxiv, 2026.07 · Scholar only — 2026 Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants Neel H. Shah · Science Advances 12 (21), eaea9389 · Scholar only 1 2026 Pervanadate: So much more than a protein tyrosine phosphatase inhibitor Neel H. Shah · Science Signaling 19 (921), eaed6832 · Scholar only — 2026 Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants Neel H. Shah · EMBO reports · Scholar only 3 2026 Substrate-derived peptides for selective covalent inhibition of protein tyrosine kinases Neel H. Shah · ACS Chemical Biology · Scholar only — 2025 Accurate affinity models for SH2 domains from peptide binding assays and free‐energy regression Neel H. Shah · Protein Science · Scholar only 2 2025 Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2 Neel H. Shah · bioRxiv · Scholar only 3 2025 Allosteric regulation of the tyrosine phosphatase PTP1B by a protein–protein interaction Neel H. Shah · Protein Science · Scholar only 15 2025 Deep mutational scanning of the multi-domain phosphatase SHP2 reveals mechanisms of regulation and pathogenicity Neel H. Shah · Nature Communications · Scholar only 29 2025 Profiling tyrosine kinase substrate recognition using bacterial peptide display and deep sequencing Neel H. Shah · bioRxiv · Scholar only 1 2025 SEC-MX: an approach to systematically study the interplay between protein assembly states and phosphorylation Neel H. Shah · Nature Communications · Scholar only 6 2025 The pathogenic E139D mutation stabilizes a non‐canonical active state of the multi‐domain phosphatase SHP2 Neel H. Shah · Protein Science · Scholar only 1 2024 Crafting Unnatural Peptide Macrocycles via Rh(III)-Catalyzed Carboamidation Neel H. Shah · Journal of the American Chemical Society · Scholar only 23 2024 Photocatalytic Activation of Aryl(trifluoromethyl) Diazos to Carbenes for High-Resolution Protein Labeling with Red Light Neel H. Shah · Journal of the American Chemical Society · Scholar only 67 2024 The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain Neel H. Shah · Proceedings of the National Academy of Sciences · Scholar only 22 2023 High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display Neel H. Shah · Elife · Scholar only 40 2023 Mapping the Chemical Space of Active‐Site Targeted Covalent Ligands for Protein Tyrosine Phosphatases Neel H. Shah · ChemBioChem · Scholar only 4 2023 TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments Neel H. Shah · Immunity 56 (12), 2682-2698. e9 · Scholar only 32 2022 A saturation-mutagenesis analysis of the interplay between stability and activation in Ras Neel H. Shah · Elife · Scholar only 38 2022 Modular Synthesis of Unnatural Peptides via Rh(III)-Catalyzed Diastereoselective Three-Component Carboamidation Reaction Neel H. Shah · Journal of the American Chemical Society · Scholar only 47 2022 Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning Neel H. Shah · Nature Biotechnology · Scholar only 143 2022 Saturation mutagenesis of a predicted ancestral Syk‐family kinase Neel H. Shah · Protein Science · Scholar only 20 2021 Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases Neel H. Shah · Protein Science · Scholar only 24 2021 Split inteins with exceptional splicing activity Neel H. Shah · US Patent 11,142 · Scholar only 8 2020 Identification, Characterization, and Optimization of Split Inteins Neel H. Shah · Expressed Protein Ligation: Methods and Protocols · Scholar only 7 2019 Learning from ancestors Neel H. Shah · Elife · Scholar only 1 2019 Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination Neel H. Shah · Nature immunology · Scholar only 130 2019 Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation Neel H. Shah · Nature structural & molecular biology · Scholar only 33 2019 Variation in assembly stoichiometry in non‐metazoan homologs of the hub domain of Ca2+/calmodulin‐dependent protein kinase II Neel H. Shah · Protein Science · Scholar only 26 2018 Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites Neel H. Shah · Proceedings of the National Academy of Sciences · Scholar only 56 2018 Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen Neel H. Shah · eLife · Scholar only 82 2018 Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT Neel H. Shah · Nature immunology · Scholar only 232 2018 The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases Neel H. Shah · Critical Reviews in Biochemistry and Molecular Biology · Scholar only 114 2018 ZAP-70 in signaling, biology, and disease Neel H. Shah · Annual review of immunology · Scholar only 194 2017 A Promiscuous Split Intein with Expanded Protein Engineering Applications Neel H. Shah · Proceedings of the National Academy of Sciences · Scholar only 170 2017 Deconstruction of the Ras switching cycle through saturation mutagenesis Neel H. Shah · eLife · Scholar only 152 2016 An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor Neel H. Shah · Elife · Scholar only 131 2016 Design of a Split Intein with Exceptional Protein Splicing Activity. Neel H. Shah · Journal of the American Chemical Society · Scholar only 227 2015 Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding Neel H. Shah · Biochemical Journal · Scholar only 35 2015 Split inteins, conjugates and uses thereof Neel H. Shah · US Patent App · Scholar only 108 2014 Inteins: Nature’s Gift to Protein Chemists Neel H. Shah · Chem. Sci. · Scholar only 541 2014 Split Inteins: From Mechanistic Studies to Novel Protein Engineering Technologies Neel H. Shah · Scholar only — 2014 Structural and Dynamical Features of Inteins and Implications on Protein Splicing Neel H. Shah · Journal of Biological Chemistry · Scholar only 101 2013 Extein Residues Play an Intimate Role in the Rate Limiting Step of Protein Trans-Splicing Neel H. Shah · Journal of the American Chemical Society · Scholar only 120 2013 Naturally Split Inteins Assemble through a “Capture and Collapse” Mechanism Neel H. Shah · Journal of the American Chemical Society · Scholar only 114 2013 Streamlined Expressed Protein Ligation Using Split Inteins Neel H. Shah · Journal of the American Chemical Society · Scholar only 113 2012 Ultrafast Protein Splicing is Common among Cyanobacterial Split Inteins: Implications for Protein Engineering Neel H. Shah · Journal of the American Chemical Society · Scholar only 188