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Journal

Proceedings of the National Academy of Sciences

Citation weight

TierB

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Each figure with its percentile among the ranked journals. A is the median, over the academics with a work here, of that academic’s citations to the works this site counts for them - never a Google Scholar profile total. Over every academic of this field, all years, whatever the filters select.

A · academics’ median11,736.0 · 45%

B · citations per work217.1 · 81%

N · works425 · 98%

P · academics91 · 99%

Formula result0.968

From this institution

Under these filters. A work with no citation count is unknown here, never a zero.

Works424

Citations86,360 over 398 of 424 works

Citations per counted work217.0

Weighted citations—

Academics91

Departments8

First seen1974

Works placed per year

424 of these 424 works carry a year; an undated work is in no year. Works placed, under these filters.

Departments publishing there 8

Department	Works
Princeton Chemistry	101
Harvard Chemistry	93
Penn Chemistry	66
Cornell Chemistry	56
Columbia Chemistry	44
Yale Chemistry	41
Brown Chemistry	16
Dartmouth Chemistry	14

A work held by two departments counts once in each, so these add up to more than the works above.

Works placed there 424

Year	Title	Academics	Citations
2014	The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition	Pamela Chang	2,647
2007	Copper-free click chemistry for dynamic in vivo imaging	Jeremy M. Baskin · Pamela Chang	2,550
2005	Potential energy functions for atomic-level simulations of water, and organic and biomolecular systems.	William Jorgensen	1,966
2004	Electrical detection of single viruses	Xiaowei Zhuang	1,789
1998	Expressed Protein Ligation: A General Method For Protein Engineering	Tom Muir	1,642
2018	Developing a Molecular Dynamics Force Field for Both Folded and Disordered Protein States	Paul Robustelli	1,183
2014	Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling	Ming Xian	1,080
2007	Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles	Barbara A. Baird · Tobias Baumgart	1,069
2003	Visualizing infection of individual influenza viruses	Xiaowei Zhuang	947
2010	Attractive Non-Covalent Interactions in Asymmetric Catalysis: Links Between Enzymes and Small-Molecule Catalysts	Robert Knowles	945
2019	Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression	Xiaowei Zhuang	894
2010	Copper-free click chemistry in living animals	Jeremy M. Baskin · Pamela Chang	873
2010	Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling	Christopher J. Chang	872
2013	Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids	Joshua Rabinowitz	862
2016	Optical magnetic detection of single-neuron action potentials using quantum defects in diamond	Hongkun Park	858
2011	Cobalt-Dithiolene Complexes for the Photocatalytic and Electrocatalytic Reduction of Protons	Patrick Holland	792
2011	A General Strategy for the Evolution of Bond-Forming Enzymes Using Yeast Display	David R. Liu	758
2020	Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor	Pamela Chang	757
2016	Efficient Delivery of Genome-Editing Proteins using Bioreducible Lipid Nanoparticles	David R. Liu	742
2000	Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries	Jon Ellman	740
2012	Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.	Emily Balskus	718
1993	Engineering of stable and fast-folding sequences of model proteins.	Eugene I. Shakhnovich	694
2010	Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells	Hongkun Park	692
2016	High-throughput single- cell gene expression profiling with multiplexed error-robust fluorescence in situ hybridization (MERFISH)	Xiaowei Zhuang	672
1999	Structure-activity analysis of the thiolactone peptides from Staphylococcus aureus responsible for virulence.	Tom Muir	661
2005	Planar-to-Tubular Structural Transition in Boron Clusters: B20 as the Embryo of Single-Walled Boron Nanotubes	Lai-Sheng Wang	650
2009	Designer Disordered Materials With Large Complete Photonic Band Gaps	Salvatore Torquato	650
2004	tRNA dynamics on the ribosome during translation	Ruben L Gonzalez Jr	635
2012	Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes	Xiaowei Zhuang	614
2002	Network of coupled promoting motions in enzyme catalysis	Sharon Hammes-Schiffer	595
2017	Nitric Oxide is an Obligate Bacterial Nitrification Intermediate Produced by Hydroxylamine Oxidoreductase	Kyle M. Lancaster	591
2017	Exceedingly Small Iron Oxide Nanoparticles as Positive MRI Contrast Agents	Ou Chen	577
2017	Ab initio theory and modeling of water	Roberto Car	540
2004	Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition–cyclization strategy: Synthesis of (–)-flustramine B	David MacMillan	534
2012	A Novel Autophagy Inhibitor with Single Agent Antitumor Activity Reproduces the Phenotype of a Genetic Autophagy Deficiency	Jeffrey D. Winkler	498
2012	Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation	Joshua Rabinowitz	488
2010	In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter	Christopher J. Chang	469
1994	The Combinatorial Synthesis, and Chemical and Biological Evaluation of a 1,4-Benzodiazepine Library	Jon Ellman	462
1999	De Novo Amyloid Proteins From Designed Combinatorial Libraries	Michael Hecht	461
1999	Progress Towards the Evolution of an Organism with an Expanded Genetic Code	David R. Liu	458
2006	Evidence of Hollow Golden Cages	Lai-Sheng Wang	451
2014	Characterization and development of photoactivatable fluorescent proteins for single-molecule-based superresolution imaging	Xiaowei Zhuang	450
2006	The Pathogen-Associated iroA Gene Cluster Mediates Bacterial Evasion of Lipocalin 2	David R. Liu	449
2003	Watching proteins fold one molecule at a time	Elizabeth Rhoades	449
2001	Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells	David W. Christianson	440
2016	New type of Weyl semimetal with quadratic double Weyl fermions	Suyang Xu	436
2002	Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase	David W. Christianson	419
2012	Phase separation and rotor self-assembly in active particle suspensions	Angelo Cacciuto	415
2013	Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production	Christopher J. Chang	414
2005	Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes	Barbara A. Baird · Tobias Baumgart	413
1995	FcRI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling	Barbara A. Baird	401
2008	Multiplex Protein Assays Based on Real-Time Magnetic Nanotag Sensing	Shouheng Sun	384
1998	NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains	Dale F. Mierke	382
1995	A test of lattice protein folding algorithms.	Eugene I. Shakhnovich	381
2000	Rational Design of a Global Inhibitor of the Virulence Response in S.aureus, Based in Part Upon Localization of the Site of Inhibition to the Receptor-Histidine Kinase, AgrC.	Tom Muir	379
2007	The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis	Frank C. Schroeder	375
2016	High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing	Xiaowei Zhuang	374
1996	Kinetic discrimination in T-cell activation.	Joshua Rabinowitz	374
2002	Topological determinants of protein folding	Eugene I. Shakhnovich	370
2009	De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers	Jeffrey D. Winkler	370
1995	Periodicity of Polar and Non-Polar Amino Acids is the Major Determinant of Secondary Structure in Self-Assembling Oligomeric Peptides	Michael Hecht	370
1999	Ligand-induced conformational changes of single RNA molecules	Xiaowei Zhuang	367
2009	Mammalian Cell Penetration, siRNA Transfection, and DNA Transfection by Supercharged Proteins	David R. Liu	367
2005	Physics and evolution of thermophilic adaptation	Eugene I. Shakhnovich	364
2009	A Superior Descriptor of Random Textures and Its Predictive Capacity	Salvatore Torquato	361
2006	Conservation of the metabolomic response to starvation across two divergent microbes	Joshua Rabinowitz	352
1997	Engineering a tRNA and Aminoacyl-tRNA Synthetase for the Site-Specific Incorporation of Unnatural Amino Acids into Proteins in Vivo	David R. Liu	349
2015	Hybrid bioinorganic approach to solar-to-chemical conversion	Christopher J. Chang	349
2001	Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade	David W. Christianson	348
2006	Suppressing Brownian motion of individual biomolecules in solution	Adam Cohen	347
2008	Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo	Michael J. Ragusa	342
2007	Protein stability imposes limits on organism complexity and speed of molecular evolution	Eugene I. Shakhnovich	330
2009	Slow Peptide Bond Formation by Proline and Other N-alkylamino Acids in Translation	Virginia W. Cornish	329
1999	Chemical Ligation of Folded Recombinant Proteins: Segmental Isotopic Labeling of Domains for NMR Studies	Tom Muir	329
2013	Novel Experiments on Freeform Waveguides and Isotropic Photonic Bandgaps in Hyperuniform Disordered Systems	Salvatore Torquato	324
2009	A shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans	Frank C. Schroeder	315
2002	Exploring the folding landscape of a structured RNA	Xiaowei Zhuang	314
2019	The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins	Stacy Malaker	313
2017	Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma	Joshua Rabinowitz	303
2000	Combinatorial Target-Guided Ligand Assembly. Identification of Potent, Sub-type Selective c-Src Inhibitors	Jon Ellman	303
2009	Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.	Megan L. Matthews · Squire J. Booker	291
2018	Stable iridium dinuclear heterogeneous catalysts supported on metal-oxide substrate for solar water oxidation	Gary Brudvig	290
1999	Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase	David W. Christianson	288
2016	Nitrosomonas europaea Cytochrome P460 Is a Direct Link between Nitrification and Nitrous Oxide Emission	Kyle M. Lancaster	279
2007	Grass roots chemistry: meta-tyrosine, an herbicidal nonprotein amino acid	Frank C. Schroeder	278
2012	Collective Many-Body van der Waals Interactions in Molecular Systems	Robert A. DiStasio Jr.	276
2003	Single-molecule transition-state analysis of RNA folding	Xiaowei Zhuang	274
2000	Fluorescence quenching: a tool for single-molecule protein-folding study	Xiaowei Zhuang	272
2012	Amorfrutins are potent antidiabetic dietary natural products	Frank C. Schroeder	271
2004	A tautomeric zinc sensor for ratiometric fluorescence imaging: Application to nitric oxide-induced release of intracellular zinc	Christopher J. Chang	268
2006	Generic Hydrophobic Residues are Sufficient to Promote Aggregation of the Alzheimer’s Ab42 Peptide	Michael Hecht	265
2017	Characterization of NiFe oxyhydroxide electrocatalysts by integrated electronic structure calculations and spectroelectrochemistry	Sharon Hammes-Schiffer	264
1986	Mechanism for photosynthetic O2 evolution.	Gary Brudvig	264
2012	Kinetic and structural studies, origins of selectivity, and interfacial charge transfer in the artificial photosynthesis of CO	James Mayer	260
2019	Accurate Molecular Polarizabilities with Coupled-Cluster Theory and Machine Learning	Robert A. DiStasio Jr.	255
2020	Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity	Joshua Rabinowitz	254
2008	Epsin1 is a cargo specific adaptor for the clathrin-mediated endocytosis of influenza virus	Xiaowei Zhuang	252
1998	How evolution makes proteins fold quickly	Eugene I. Shakhnovich	250
1998	Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA	David W. Christianson	248
2012	Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model	Christopher J. Chang	244
1994	Site-Specific Incorporation of Biophysical Probes into Proteins	Virginia W. Cornish	242
2003	Kinks, Rings, and Rackets in Filamentous Structures	Adam Cohen	240
2011	A biophysical protein folding model accounts for most mutational fitness effects in viruses	Eugene I. Shakhnovich	240
2017	Identification of individuals by trait prediction using whole-genome sequencing data	Christopher J. Chang	240
2005	Crystal structure of human arginase I at 1.29-Å resolution and exploration of inhibition in the immune response	David W. Christianson	237
2006	Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase	Jason M. Crawford	236
2018	New Molecular Switch Architectures	Ivan Aprahamian	235
2016	Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species	Xiaowei Zhuang	233
2014	Role of pendant proton relays and proton-coupled electron transfer on the hydrogen evolution reaction by nickel hangman porphyrins	Sharon Hammes-Schiffer	233
2011	Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy	Christopher J. Chang	231
2012	Small molecule perimeter defense in entomopathogenic bacteria	Jason M. Crawford	231
2002	Expanding protein universe and its origin from the biological Big Bang	Eugene I. Shakhnovich	230
2016	In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease	Christopher J. Chang	227
2007	Mechanisms of Photoswitch Conjugation and Light Activation of an Ionotropic Glutamate Receptor	Dirk Trauner	226
2002	Rationally Designed Mutations Convert De Novo Amyloid-Like Fibrils into Soluble Monomeric b-Sheet Proteins	Michael Hecht	224
2017	Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors	David W. Christianson	210
1984	Effect of Single Amino Acid Replacements on the Thermal Stability of the Amino Terminal Domain of Phage l-Repressor	Michael Hecht	210
2020	Signatures of a liquid–liquid transition in an ab initio deep neural network model for water	Roberto Car	210
2002	The ensemble folding kinetics of protein G from an all-atom Monte Carlo simulation	Eugene I. Shakhnovich	208
2004	Semisynthesis of a Segmental Isotopically Labeled Protein Splicing Precursor: NMR Evidence for an Unusual Peptide Bond at the N-Extein-Intein Junction.	Tom Muir	208
2003	Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis	David W. Christianson	205
2001	Length-Dependent Stability and Strand Length Limits in Antiparallel -Sheet Secondary Structure.	Tom Muir	205
2006	On the origin and highly likely completeness of single-domain protein structures	Eugene I. Shakhnovich	204
1996	Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-Å resolution	David W. Christianson	203
2016	Nickel phlorin intermediate formed by proton-coupled electron transfer in hydrogen evolution mechanism	Sharon Hammes-Schiffer	200
2003	Counterion Switch in the Photoactivation of G Protein-Coupled Receptor Rhodopsin	E. Chui-Ying Yan	198
2009	Allosteric modulation of DNA by small molecules	David M. Chenoweth	197
1983	Mutations in l-Repressor's Amino-Terminal Domain: Implications for Protein Stability and DNA Binding	Michael Hecht	197
2003	Programming Peptidomimetic Syntheses by Translating Genetic Codes Designed De Novo	Virginia W. Cornish	195
2019	A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.	Emily Balskus	195
2010	Visualizing enveloping layer glycans during zebrafish early embryogenesis	Jeremy M. Baskin	194
2004	Single-molecule enzymology of RNA: Essential functional groups impact catalysis from a distance	Xiaowei Zhuang	194
2011	Electrokinetic trapping at the one nanometer limit	Adam Cohen	193
2014	Wireless gas detection with a smartphone via rf communication	Katherine A. Mirica	192
2013	Rapid prototyping of carbon-based chemiresistive gas sensors on paper	Katherine A. Mirica	192
2019	Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy	Laura J. Kaufman	191
2005	Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase	Sharon Hammes-Schiffer	191
2017	Structural Organization of the Actin-spectrin-based Membrane Skeleton in Dendrites and Soma of Neurons	Xiaowei Zhuang	190
2010	Dynamic sorting of lipids and proteins in membrane tubes with a moving phase boundary	Tobias Baumgart	190
2004	Visualization of plasma membrane compartmentalization with patterned lipid bilayers	Barbara A. Baird	188
2003	Optimal alignment for enzymatic proton transfer: structure of the Michaelis complex of triosephosphate isomerase at 1.2-Å resolution	Ann E. McDermott	186
2019	Revealing the atomic ordering of binary intermetallics using in situ heating techniques at multilength scales	Yao Yang	184
2022	Reliably assessing the electronic structure of cytochrome P450 on today’s classical computers and tomorrow’s quantum computers	Joonho Lee	183
2008	Conformational changes of calmodulin upon Ca2+ binding studied with a microfluidic mixer	Elizabeth Rhoades	182
2014	Copper is an endogenous modulator of neural circuit spontaneous activity	Christopher J. Chang	181
2013	Mechanism of voltage-sensitive fluorescence in a microbial rhodopsin	Adam Cohen	178
2013	H3R42me2a is a histone modification with positive transcriptional effects	Tom Muir	178
2006	Packing, Tiling and Covering with Tetrahedra	Salvatore Torquato	178
2010	Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.	F. Jon Kull	176
1995	Evolution-like selection of fast-folding model proteins.	Eugene I. Shakhnovich	176
2021	Genome-wide CRISPR screens reveal a specific ligand for glycan-binding immune checkpoint receptor Siglec-7	Stacy Malaker	175
2009	Allosteric collaboration between elongation factor G and the ribosomal L1 stalk directs tRNA movements during translation	Ruben L Gonzalez Jr	174
2020	Probing and manipulating embryogenesis via nanoscale thermometry and temperature control	Hongkun Park	174
2007	Dietary sequestration of defensive steroids in nuchal glands of the Asian snake Rhabdophis tigrinus	Frank C. Schroeder	171
2017	A Promiscuous Split Intein with Expanded Protein Engineering Applications	Neel H. Shah · Tom Muir	170
2016	Biophysical principles predict fitness landscapes of drug resistance	Eugene I. Shakhnovich	167
2009	Traceless Protein Ligation Using Evolved Split Inteins	Tom Muir	167
2013	A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy	Michael J. Ragusa	165
2006	Chemoresponsive monolayer transistors	Colin P. Nuckolls	165
2004	Direct Experimental Observation of the Low Ionization Potentials of Guanine in Free Oligonucleotides Using Photoelectron Spectroscopy	Lai-Sheng Wang	164
2011	Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity	Elizabeth Rhoades	162
2019	Structural maturation of cortical perineuronal nets and their perforating synapses revealed by super-resolution imaging	Xiaowei Zhuang	161
2014	A model for the generation and interconversion of ER morphologies	Xiaowei Zhuang	161
1999	Evidence for the role of PrPC helix 1 in the hydrophilic seeding of prion aggregates	Eugene I. Shakhnovich	161
2003	Solution Structure of a De Novo Protein from a Designed Combinatorial Library	Michael Hecht	160
1986	X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature.	David W. Christianson	157
2012	Interaction of structure-specific and promiscuous G-protein–coupled receptors mediates small-molecule signaling in Caenorhabditis elegans	Frank C. Schroeder	155
2008	Probing concerted proton–electron transfer in phenol–imidazoles	James Mayer	155
2002	Autoregulation of a Bacterial Sigma Factor Explored Using Segmental Labeling and NMR	Tom Muir	154
2018	HELLS and CDCA7 comprise a bipartitie nucleosome remodeling complex defective in ICF syndrome	Tom Muir	154
2013	X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification	Squire J. Booker	152
2000	Emergent mechanical properties of self-assembled polymeric capsules	Colin P. Nuckolls	151
2019	Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization	Xiaowei Zhuang	150
2020	Cavity Molecular Dynamics Simulations of Liquid Water under Vibrational Ultrastrong Coupling	Abraham Nitzan · Joseph Subotnik	149
1995	Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.	David W. Christianson	149
2020	An Enzymatic Toolkit for Selective Proteolysis, Detection, and Visualization of Mucin-Domain Glycoproteins	Stacy Malaker	147
1979	Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.	Gary Brudvig	147
2010	Predicting organic hydrogen atom transfer rate constants using the Marcus cross relation	James Mayer	146
2012	Ultrafast photodriven intramolecular electron transfer from an iridium-based water-oxidation catalyst to perylene diimide derivatives	Gary Brudvig	143
2010	Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis	Jason M. Crawford	143
2010	Artificial atoms on semiconductor surfaces	Xiaoyang Zhu	139
2022	High-resolution cryo-electron microscopy structure of photosystem II from the mesophilic cyanobacterium, Synechocystis sp. PCC 6803	Gary Brudvig	139
2006	A simple physical model for scaling in protein-protein interaction networks	Eugene I. Shakhnovich	137
2016	Crystallographic snapshots of sulfur insertion by lipoyl synthase	Squire J. Booker	135
2018	Observation of Highly Stable and Symmetric Lanthanide Octa-Boron Inverse Sandwich Clusters	Lai-Sheng Wang	134
2015	Purinosome formation as a function of the cell cycle	Xiaowei Zhuang	134
2015	Rational design of self-assembly pathways for complex multicomponent structures	William M. Jacobs	134
2001	Self-Assembled Monolayers from a Designed Combinatorial Library of De Novo b-sheet Proteins	Michael Hecht	133
1996	Mapping protein-protein interactions by affinity-directed mass spectrometry.	Tom Muir	132
2001	Probing the open state of cytochrome P450cam with ruthenium-linker substrates	Ivan J. Dmochowski	131
2010	Multicatalytic, Asymmetric Michael/Stetter Reaction of Salicylaldehydes and Activated Alkynes	Tomislav Rovis	130
2014	A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation	Ruben L Gonzalez Jr	130
2001	Constructing, verifying, and dissecting the folding transition state of chymotrypsin inhibitor 2 with all-atom simulations	Eugene I. Shakhnovich	130
2004	Glycine as a D-amino acid surrogate in the K+ selectivity filter.	Tom Muir	130
1993	Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii.	Squire J. Booker	129
2011	Reiterative Recombination for the In Vivo Assembly of Libraries of Multi-Gene Pathways	Virginia W. Cornish	128
2007	Small Molecule-Mediated Rescue of Protein Function by an Inducible Proteolytic Shunt	Tom Muir	128
1994	De Novo Design of b-Sheet Proteins (Commentary)	Michael Hecht	127
1998	Sulfur K-edge x-ray absorption spectroscopy: A spectroscopic tool to examine the redox state of S-containing metabolites in vivo	Ann E. McDermott	126
2004	Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing	Tom Muir	126
2004	A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity	Dale F. Mierke	124
2013	Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1	Frank C. Schroeder	123
2002	Combinatorial computational method gives new picomolar ligands for a known enzyme	David W. Christianson · Eugene I. Shakhnovich	123
2017	Evidence of evolutionary selection for cotranslational folding	Eugene I. Shakhnovich	123
2017	Evidence of evolutionary selection for co-translational folding	William M. Jacobs	123
2019	The histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase	Tom Muir	123
2012	Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations	Eugene I. Shakhnovich	122
2013	Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans	Sharon Hammes-Schiffer	122
2014	Existence of Isostatic, Maximally Random Jammed Monodisperse Hard-Disk Packings	Salvatore Torquato	121
2003	Natural selection of more designable folds: a mechanism for thermophilic adaptation	Eugene I. Shakhnovich	119
2003	Superoxo, μ-peroxo and μ-oxo complexes from heme/O2 and heme-Cu/O2 reactivity: Copper-ligand influences in cytochrome c oxidase models.	Eunsuk Kim	118
2019	Topology on a new facet of bismuth	Suyang Xu	118
2007	Principal Components Analysis of shape fluctuations of single DNA molecules	Adam Cohen	117
2011	Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions	Eugene I. Shakhnovich	117
2020	The alarmones (p) ppGpp directly regulate translation initiation during entry into quiescence	Ruben L Gonzalez Jr	116
2000	Chemical defense: bestowal of a nuptial alkaloidal garment by a male moth on its mate	Frank C. Schroeder	116
2020	Direct kinetic measurements and theoretical predictions of an isoprene-derived Criegee intermediate	Marsha I. Lester · Patrick J. Walsh	116
2013	A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases	Squire J. Booker	116
2006	Pinoresinol: A lignol of plant origin serving for defense in a caterpillar	Frank C. Schroeder	115
2020	Natural diversity in the predatory behavior facilitates the establishment of a robust model strain for nematode-trapping fungi	Frank C. Schroeder	114
2003	Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases	Eugene I. Shakhnovich	114
2013	Hyperuniformity in Amorphous Silicon Based on the Measurement of the Inﬁnite-Wavelength Limit of the Structure Factor	Salvatore Torquato	114
1987	Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue.	David W. Christianson	113
2014	Transmembrane allosteric coupling of the gates in a potassium channel	Ann E. McDermott	112
2015	Enhancement of Radiation Effect on Cancer Cells by Gold-pHLIP (pH Low Insertion Peptide)	Shouheng Sun	111
2015	The Ribosome Can Discriminate the Chirality of Amino Acids Within Its Peptidyl Transferase Center	Ruben L Gonzalez Jr · Virginia W. Cornish	111
2019	Octahedral spinel electrocatalysts for alkaline fuel cells	Yao Yang	111
2009	agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides	Tom Muir	111
2007	Dissecting the multi-step reaction pathway of an RNA enzyme by single-molecule kinetic fingerprinting	Xiaowei Zhuang	110
2015	Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis	Squire J. Booker	108
2017	Decoupling of Surface Diffusion and Relaxation Dynamics of Molecular Glasses	Zahra Fakhraai	107
2004	A fluorophore attached to nicotinic acetylcholine receptor βM2 detects productive binding of agonist to the αδ site	E. James Petersson	107
2020	Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation	Stacy Malaker	107
2022	A completely precious metal–free alkaline fuel cell with enhanced performance using a carbon-coated nickel anode	Yao Yang	105
2008	Conformational dynamics of an intact virus: order parameters for the coat protein of Pf1 bacteriophage	Ann E. McDermott	104
2021	Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout	Tom Muir	104
2019	A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity	Jeremy M. Baskin	103
2002	Chemical Complementation: A Reaction-Independent, High-Throughput Genetic Assay for Enzyme Catalysis	Virginia W. Cornish	102
2012	Insights into proton-coupled electron transfer mechanisms of electrocatalytic H2 oxidation and production	Sharon Hammes-Schiffer	102
2016	Accomplishing simple, solubility-based separations of rare earth elements with complexes bearing size-sensitive molecular apertures	Eric J. Schelter	101
2009	Nanosculpting Reversed Wavelength Sensitivity Into a Photoswitchable iGluR	Dirk Trauner	99
2017	Efficient assignment and NMR analysis of an intact virus using sequential side-chain correlations and DNP sensitization	Ann E. McDermott	98
2018	Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria	Xiaowei Zhuang	97
2017	Dual Optical Control and Mechanistic Insights Into Photoswitchable Group II and III Metabotropic Glutamate Receptors	Dirk Trauner	97
2015	Ideal probe single-molecule experiments reveal the intrinsic dynamic heterogeneity of a supercooled liquid	Laura J. Kaufman	96
2007	Dynamics of equilibrium structural fluctuations of apomyoglobin measured by fluorescence correlation spectroscopy	Elizabeth Rhoades	96
2008	NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species	Frank C. Schroeder	95
2013	X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry	Squire J. Booker	95
2016	A functional role for intrinsic disorder in the tau-tubulin complex	Elizabeth Rhoades	95
2024	Is Stochastic Thermodynamics the Key to Understanding the Energy Costs of Computation?	Brenda Rubenstein	93
2017	Architecture of the human PI4KIIIα lipid kinase complex	Jeremy M. Baskin	92
2007	Robust protein–protein interactions in crowded cellular environments	Eugene I. Shakhnovich	92
2024	Stabilizing Ti 3 C 2 T x MXene flakes in air by removing confined water	Zahra Fakhraai	92
2023	A genetically encoded photoproximity labeling approach for mapping protein territories	Tom Muir	92
2016	A [3Fe-4S] cluster is required for tRNA thiolation in archaea and eukaryotes	Patrick Holland	92
2012	Protonation state of E71 in KcsA and its role for channel collapse and inactivation	Ann E. McDermott	91
2012	Direct substitution and assisted dissociation pathways for turning off transcription by a MerR-family metalloregulator	Peng Chen	91
2002	A structure-based method for derivation of all-atom potentials for protein folding	Eugene I. Shakhnovich	91
2015	Key driving forces in the biosynthesis of autoinducing peptides required for staphyloccal virulence.	Tom Muir	91
2017	Ultrathin dendrimer–graphene oxide composite film for stable cycling lithium–sulfur batteries	Hailiang Wang	91
2012	Sex-specific mating pheromones in the nematode Panagrellus redivivus	Frank C. Schroeder	90
2021	Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N-nitrosourea-producing enzyme SznF.	Emily Balskus	90
2017	Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission	Tobias Baumgart	89
1997	Combinatorial Thinking in Chemistry and Biology	Jon Ellman	89
2013	Exploiting imperfections in the bulk to direct assembly of surface colloids	Tobias Baumgart	88
2011	Measurement of radon and xenon binding to a cryptophane molecular host	Ivan J. Dmochowski	87
2014	Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: Temporal order and the roles of Asp27 and Tyr100	Sharon Hammes-Schiffer	87
2014	Assembly and dynamics of the autophagy-initiating Atg1 complex	Michael J. Ragusa	86
1974	Threshold excitations, relaxation oscillations and effect of noise on an enzyme reaction	Abraham Nitzan	84
2014	Tau mutants bind tubulin heterodimers with enhanced affinity	Elizabeth Rhoades	84
2015	Protein synthesis during cellular quiescence is inhibited by phosphorylation of a translational elongation factor	Ruben L Gonzalez Jr	83
1990	Stark spectroscopy of the Rhodobacter sphaeroides reaction center heterodimer mutant	Sharon Hammes-Schiffer	83
2016	Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells	Laura J. Kaufman	80
1999	Optical detection of cytochrome P450 by sensitizer-linked substrates	Ivan J. Dmochowski	80
2010	Protein–ice interaction of an antifreeze protein observed with solid-state NMR	Ann E. McDermott	79
2022	Self-assembly of photonic crystals by controlling the nucleation and growth of DNA-coated colloids	William M. Jacobs	79
2004	Synthesis of the thapsigargins.	Emily Balskus	78
2021	Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle in vitro	Adam Cohen	78
2020	Multifunctional Composites for Elastic and Electromagnetic Wave Propagation	Salvatore Torquato	78
2001	Activated Cdc42/Rac reconstitutes FcRI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells	Barbara A. Baird	77
2018	Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA, and actin filaments	Elizabeth Rhoades	77
2022	Wave Propagation and Band Tails of Disordered Systems in the Thermodynamic Limit	Salvatore Torquato	77
2018	Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical	Megan L. Matthews	76
2021	Elucidation of an anaerobic pathway for metabolism of L-carnitine derived γ-butyrobetaine to trimethylamine in human gut bacteria.	Emily Balskus	75
2020	Live-cell protein engineering with an ultra-short split intein	Tom Muir	75
2019	βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport	Xiaowei Zhuang	74
2021	Dot1L Complex Regulates Transcriptional Initiation in Human Erythroleukemic Cells	Tom Muir	73
2019	Encoding biological recognition in a bicomponent cell-membrane mimic	Tobias Baumgart	72
2020	Developing New NHC Reactivity Rapidly via a Novel High-Throughput Analysis Platform	Benjamin McDonald	71
2021	Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity	Frank C. Schroeder	71
2020	HARC as an open-shell strategy to bypass oxidative addition in Ullmann–Goldberg couplings	Marissa Lavagnino	71
2017	Stratospheric ozone over the United States in summer linked to observations of convection and temperature via chlorine and bromine catalysis	James G. Anderson	71
2004	Catalytic Asymmetric Addition of Diphenylzinc to Cyclic ···-Unsaturated Ketones	Patrick J. Walsh	71
1996	Natural abundance solid-state carbon NMR studies of photosynthetic reaction centers with photoinduced polarization.	Ann E. McDermott	69
2016	Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans	Frank C. Schroeder	69
2005	Crystal structure of the GTPase domain of rat dynamin 1.	F. Jon Kull	68
2020	Co-translational folding allows misfolding-prone proteins to circumvent deep kinetic traps	William M. Jacobs	68
2002	Mayolenes: Labile defensive lipids from the glandular hairs of a caterpillar (Pieris rapae)	Frank C. Schroeder	67
2011	Sensing membrane stress with near-IR emissive porphyrins	Ivan J. Dmochowski	67
2009	Calix[4]arene-Based Conical-Shaped Ligands for Voltage Dependent Potassium Channels	Dirk Trauner	66

The 300 most cited of 424 works; the other 124 are not listed. Citations as counted, before any journal weight: 398 of these 424 works carry a count, and a work with no count is unknown, never a zero.