Academics · Demo University

Academic

RankUnknown

As ofnot recorded

DepartmentPrinceton Chemistry

UniversityPrinceton

FieldChemistry

ORCID0000-0002-1247-4727

Scholarprofile

Totals

Publications83

Citations62,004

h-index145 · Scholar

Citations per year in post—

Years in postno first year on the CV

Coverage

Works with a count83 of 83

Share100%

Top venues 35 venues

The 8 holding the most of these works; 27 more hold at least one.

Nature11

Cell Metabolism6

Proceedings of the National Academy of Scienc…6

Analytical Chemistry5

Genes & Development4

Nature Chemical Biology4

Science4

Cancer Research3

Publications per year

Works this academic published in each year, by the year each work appeared; an undated work is in no year, and a work two colleagues wrote counts for each of them. The kind, works and year filters decide which works are here at all.

Citations per year

Citations received in each year, from this academic’s verified Scholar profile, which counts every citation to everything they ever wrote: no publication filter reaches this line - not the kinds, not the works switch, not the year window on publication - and no journal weight either. It is a profile total, so it does not match the works listed below.

Publications 83 works

Every work these filters select, most cited first and the works with no count at the end: a work nobody has a figure for is unknown, never a zero to be ranked among the works that have one, and it prints an em dash. Each figure is that work’s own citations - Scholar’s count where there is one, else OpenAlex’s - and is not weighted.

Year	Title	Venue	Kind	Citations
2009	Cancer-associated IDH1 mutations produce 2-hydroxyglutarate	Nature	article	5,503
2017	One-carbon metabolism in health and disease	Cell Metabolism	article	2,649
2010	The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate	Cancer Cell	article	2,626
2010	Autophagy and metabolism	Science	article	2,484
2009	Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli	Nature Chemical Biology	article	2,317
2013	Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells	Nature	article	2,044
2017	Glucose feeds the TCA cycle via circulating lactate	Nature	article	1,978
2015	The return of metabolism: biochemistry and physiology of the pentose phosphate pathway	—	article	1,952
2011	Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis	Genes & Development	article	1,612
2016	Mitochondria and cancer	Molecular Cell	article	1,491
2014	Quantitative flux analysis reveals folate-dependent NADPH production	Nature	article	1,313
2020	Lactate: the ugly duckling of energy metabolism	—	article	1,257
2015	Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein	Cancer Research	article	1,059
2018	Metabolomics and isotope tracing	Cell	article	1,045
2013	Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids	Proceedings of the National Academy of Sciences	article	862
2010	Evidence for an alternative glycolytic pathway in rapidly proliferating cells	Science	article	795
2010	Metabolomic analysis and visualization engine for LC–MS data	Analytical Chemistry	article	784
2008	Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy	Nature Biotechnology	article	777
2015	A roadmap for interpreting 13C metabolite labeling patterns from cells	Current Opinion in Biotechnology	article	771
2006	Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry	Journal of Chromatography A	article	771
2023	The pentose phosphate pathway in health and disease	—	article	725
2016	A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance	Nature Medicine	article	712
2012	LC‐MS data processing with MAVEN: a metabolomic analysis and visualization engine	Current Protocols in Bioinformatics	article	707
2008	Analytical strategies for LC–MS-based targeted metabolomics	—	article	692
2013	Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis	Genes & Development	article	668
2010	Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer	Analytical Chemistry	article	663
2010	Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1	Cancer Research	article	653
2020	Comprehensive quantification of fuel use by the failing and nonfailing human heart	Science	article	650
2014	Autophagy is required for glucose homeostasis and lung tumor maintenance	Cancer Discovery	article	623
2020	Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate	Nature	article	613
2017	Metabolite measurement: pitfalls to avoid and practices to follow	Annual Review of Biochemistry	article	601
2008	Quorum Sensing Controls Biofilm Formation in Vibrio cholerae through Modulation of Cyclic Di-GMP Levels and Repression of vpsT	Journal of Bacteriology	article	580
2013	Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia	Molecular Systems Biology	article	558
2016	Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway	Cell Metabolism	article	557
2021	Restoring metabolism of myeloid cells reverses cognitive decline in ageing	Nature	article	555
2016	Metabolite concentrations, fluxes and free energies imply efficient enzyme usage	Nature Chemical Biology	article	548
2019	Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation	Nature Immunology	article	545
2014	Serine catabolism regulates mitochondrial redox control during hypoxia	Cancer Discovery	article	536
2014	Enzyme clustering accelerates processing of intermediates through metabolic channeling	Nature Biotechnology	article	528
2006	Dynamics of the cellular metabolome during human cytomegalovirus infection	PLoS Pathogens	article	528
2010	Quiescent Fibroblasts Exhibit High Metabolic Activity	PLoS Biology	article	522
2016	Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation	Cell Metabolism	article	521
2014	Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion	Molecular Cell	article	508
2008	Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach	Nature Protocols	article	508
2010	The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism	Genes & Development	article	503
2012	Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation	Proceedings of the National Academy of Sciences	article	488
2011	Itaconic acid is a mammalian metabolite induced during macrophage activation	Journal of the American Chemical Society	article	486
2019	NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism	—	article	468
1998	Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands	Immunity	article	460
2011	Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism	PLoS Pathogens	article	457
2007	Acidic Acetonitrile for Cellular Metabolome Extraction from Escherichia coli	Analytical Chemistry	article	451
2016	Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells	Genes & Development	article	440
2016	Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle	Cell Metabolism	article	439
2020	CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels	—	article	406
2017	Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors	Nature Medicine	article	387
2018	Autophagy maintains tumour growth through circulating arginine	Nature	article	374
1996	Kinetic discrimination in T-cell activation.	Proceedings of the National Academy of Sciences	article	374
2009	Host-parasite interactions revealed by Plasmodium falciparum metabolomics	Cell Host & Microbe	article	366
2020	SLC25A51 is a mammalian mitochondrial NAD+ transporter	Nature	article	364
2016	Systems-level analysis of mechanisms regulating yeast metabolic flux	Science	article	363
2016	Metabolic control of methylation and acetylation	Current Opinion in Chemical Biology	article	354
2006	Conservation of the metabolomic response to starvation across two divergent microbes	Proceedings of the National Academy of Sciences	article	352
2016	Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production	Cell Metabolism	article	350
2010	Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations	Molecular Biology of the Cell	article	337
2023	Slow TCA flux and ATP production in primary solid tumours but not metastases	Nature	article	331
2017	Metabolite spectral accuracy on orbitraps	Analytical Chemistry	article	331
2008	Kinetic flux profiling for quantitation of cellular metabolic fluxes	Nature Protocols	article	331
2015	Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation	Cell Metabolism	article	320
2021	Metabolite discovery through global annotation of untargeted metabolomics data	Nature Methods	article	317
2018	Mitochondrial translation requires folate-dependent tRNA methylation	Nature	article	316
2017	Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma	Proceedings of the National Academy of Sciences	article	303
2019	Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function	Nature	article	299
2011	α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition	Nature Chemical Biology	article	299
2014	Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate	—	article	283
2007	PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors	Journal of Neuroscience	article	280
2019	The tumor metabolic microenvironment: lessons from lactate	Cancer Research	article	261
2020	Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity	Proceedings of the National Academy of Sciences	article	254
2015	Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography–mass spectrometry-based metabolomics	Analytical Chemistry	article	254
2015	Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite D‑2-Hydroxyglutarate	ACS Chemical Biology	article	250
1997	Kinetics and extent of T cell activation as measured with the calcium signal	The Journal of Experimental Medicine	article	249
2010	Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases	mBio	article	248
2020	A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway	Nature Chemical Biology	article	234
2018	Extraction and quantitation of nicotinamide adenine dinucleotide redox cofactors	Antioxidants and Redox Signaling	article	234

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