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Academic

Tom Muir

Academic

RankDistinguished

As ofCV answer

DepartmentPrinceton Chemistry

UniversityPrinceton

FieldChemistry

ORCID0000-0001-9635-0344

Scholarprofile

Totals

Publications236

Citations40,472

h-index107 · Scholar

Citations per year in post1,349.1

Years in post30 from the CV positions

Coverage

Works with a count225 of 236

Share95%

Positions

Affiliate of the Lewis-Sigler Institute for I…2015–2020

Van Zandt Williams, Jr. Class of ’65 Professo…2010

Richard E. Salomon Family Professor, The Rock…2005

Director, The Rockefeller University2005

Associate Professor, The Rockefeller Universi…2000

Head of Laboratory2000

Assistant Professor, The Rockefeller Universi…1996

Head of Laboratory1996

and 2 more

Top venues 62 venues

The 8 holding the most of these works; 54 more hold at least one.

Journal of the American Chemical Society38

Proceedings of the National Academy of Scienc…31

Nature Chemical Biology15

Angewandte Chemie International Edition12

Nature11

Chemistry & Biology7

Molecular Cell7

Cell6

Publications per year

Works this academic published in each year, by the year each work appeared; an undated work is in no year, and a work two colleagues wrote counts for each of them. The kind, works and year filters decide which works are here at all.

Citations per year

Citations received in each year, from this academic’s verified Scholar profile, which counts every citation to everything they ever wrote: no publication filter reaches this line - not the kinds, not the works switch, not the year window on publication - and no journal weight either. It is a profile total, so it does not match the works listed below.

Publications 236 works

Every work these filters select, most cited first and the works with no count at the end: a work nobody has a figure for is unknown, never a zero to be ranked among the works that have one, and it prints an em dash. Each figure is that work’s own citations - Scholar’s count where there is one, else OpenAlex’s - and is not weighted.

Year	Title	Venue	Kind	Citations
1994	Synthesis of Proteins by Native Chemical Ligation.	Science	article	5,354
1998	Expressed Protein Ligation: A General Method For Protein Engineering	Proceedings of the National Academy of Sciences	article	1,642
2013	Inhibition of PRC2 activity by gain-of-function H3 mutations found in pediatric glioblastoma	Science	article	1,581
2018	How many human proteoforms are there?	Nature Chemical Biology	article	1,201
2010	Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB	Nature	article	1,007
2003	Semisynthesis of Proteins by Expressed Protein Ligation	Annual Review of Biochemistry	article	946
1999	Structure-activity analysis of the thiolactone peptides from Staphylococcus aureus responsible for virulence.	Proceedings of the National Academy of Sciences	article	661
2008	Chemically ubiquitylated histone 2B stimulates hDot1L-mediated intranucleosomal methylation	Nature	article	653
2009	RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells	Cell	article	650
2019	Glutamine 5 serotonylation in histone H3 is a permissive modification that functions combinatorially with H3K4me3 to potentiate TFIID interactions	Nature	article	560
2001	The TGF Receptor Activation Process: An Inhibitor to Substrate Docking Switch	Molecular Cell	article	557
2011	H2B Ubiquitylation Disrupts Local and Higher-Order Chromatin Compaction	Nature Chemical Biology	article	548
2014	Inteins: Nature’s Gift to Protein Chemists	Chemical Science	article	541
2006	Protein Ligation: An Enabling Technology for the Biophysical Analysis of Proteins	Nature Methods	article	464
2001	Crystal Structure of a Phosphorylated Smad2: Recognition of Phosphoserine by the MH2 Domain and Insights on Smad Function in TGF- Signaling	Molecular Cell	article	454
2011	BPTF recognizes a mononucleosome-level histone modification pattern via multivalent interactions	Cell	article	451
2016	Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape	Science	article	449
2019	The expanding landscape of ‘oncohistone’ mutations in human cancers	Nature	article	447
2000	“Exfoliatin-producing strains define a fourth Agr specificity group in Staphylococcus aureus”	Journal of Bacteriology	article	391
2000	Rational Design of a Global Inhibitor of the Virulence Response in S.aureus, Based in Part Upon Localization of the Site of Inhibition to the Receptor-Histidin…	Proceedings of the National Academy of Sciences	article	379
1999	Chemical Ligation of Folded Recombinant Proteins: Segmental Isotopic Labeling of Domains for NMR Studies	Proceedings of the National Academy of Sciences	article	329
2016	Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles.	Cell chemical biology	article	321
2003	The Structure of Microcin J25, a Peptide Inhibitor of Bacterial RNA Polymerase, is a Lassoed Tail	Journal of the American Chemical Society	article	313
1998	Expressed Protein Ligation: A novel method for studying protein-protein interactions in transcription.	Journal of Biological Chemistry	article	306
2002	Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus	Biochemistry	article	290
2010	Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation	Nature Chemical Biology	article	289
2015	Histones: At the Crossroads of Peptide and Protein Chemistry	Chemical Reviews	article	281
2017	PRC2 recruitment to DNA in chromatin and its inhibition by RNA reveal molecular mechanisms of epigenetic control.	Nature Structural & Molecular Biology	article	268
2019	PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism	Nature Communications	article	258
2003	A Modular Cross-linking Approach for Exploring Protein Interactions	Journal of the American Chemical Society	article	256
2003	Conditional Protein Splicing: A New Tool to Control Protein Structure and Function In Vitro and In Vivo	Journal of the American Chemical Society	article	245
1997	Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization.	The EMBO Journal	article	244
2003	Protein Semi-Synthesis in Living Cells	Journal of the American Chemical Society	article	232
1999	Virulence Gene Regulation by Peptides in Staphylococci and Other Gram-positive Bacteria.	Current Opinion in Microbiology	article	230
2017	ISWI Chromatin Remodelers Sense Nucleosome Modifications to Determine Substrate Preference	Nature	article	229
2016	Design of a Split Intein with Exceptional Protein Splicing Activity.	Journal of the American Chemical Society	article	227
2007	Molecular Mechanisms of agr Quorum Sensing in Virulent Staphylococci	ChemBioChem	article	225
2011	Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation	Journal of the American Chemical Society	article	222
2007	Auxiliary mediated site-specific peptide ubiquitylation	Angewandte Chemie International Edition	article	222
2002	Protein Splicing Triggered by a Small Molecule	Journal of the American Chemical Society	article	222
2010	Biological Applications of Protein Splicing	Cell	article	219
2002	Semi-synthesis and Folding of the Potassium Channel KcsA.	Journal of the American Chemical Society	article	218
2004	Semisynthesis of a Segmental Isotopically Labeled Protein Splicing Precursor: NMR Evidence for an Unusual Peptide Bond at the N-Extein-Intein Junction.	Proceedings of the National Academy of Sciences	article	208
2001	Length-Dependent Stability and Strand Length Limits in Antiparallel -Sheet Secondary Structure.	Proceedings of the National Academy of Sciences	article	205
2008	Activation of Protein Splicing with Light	Nature Methods	article	203
2010	Development of Stable Phosphohistidine Analogs	Journal of the American Chemical Society	article	199
2013	Set1 and p300 synergy through coupled histone modifications in transcriptional activation of p53	Cell	article	198
1998	Chemical Ligation of Unprotected Peptides Directly from a Solid Support	Journal of Peptide Research	article	191
2003	Chemical Signaling Amongst Bacteria and Its Inhibition	Chemistry & Biology	article	189
2012	Ultrafast Protein Splicing is Common among Cyanobacterial Split Inteins: Implications for Protein Engineering	Journal of the American Chemical Society	article	188
2013	The n-SET Domain of Set1 Regulates H2B Ubiquitylation-Dependent H3K4 Methylation	Molecular Cell	article	186
1994	Synthetic, Structural and Biological Studies of the Ubiquitin System. Part 1: The Total Chemical Synthesis of Ubiquitin.	Biochemical Journal	article	186
1999	Biosynthesis of a Head-to-Tail Cyclized Protein with Improved Biological Activity	Journal of the American Chemical Society	article	185
2014	Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries	Nature Methods	article	183
2014	Activation and Inhibition of the Receptor Histidine Kinase AgrC Occurs Through Opposite Helical Transduction Motions	Molecular Cell	article	181
2013	Direct Detection of Protein Histidine Phosphorylation Using a Pan Antibody	Nature Chemical Biology	article	179
2013	H3R42me2a is a histone modification with positive transcriptional effects	Proceedings of the National Academy of Sciences	article	178
2012	Chasing Phosphohistidine, An Elusive Sibling in the Phosphoamino Acid Family	ACS Chemical Biology	article	177
2006	Ion selectivity in a Semi-synthetic K+ channel locked in the conductive conformation.	Science	article	175
2015	Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins.	Nature Chemistry	article	174
2017	A Promiscuous Split Intein with Expanded Protein Engineering Applications	Proceedings of the National Academy of Sciences	article	170
2005	Development of a Tandem Protein Trans-Splicing System based on Native and Engineered Split Inteins	Journal of the American Chemical Society	article	169
2017	Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm formation	Nature Microbiology	article	167
2009	Traceless Protein Ligation Using Evolved Split Inteins	Proceedings of the National Academy of Sciences	article	167
2012	Chromatin as an Expansive Canvas for Chemical Biology	Nature Chemical Biology	article	166
2019	Impaired cell fate through gain-of-function mutations in a chromatin reader	Nature	article	163
2008	Cyclic Peptide Inhibitors of Staphyloccal Virulence Prepared by Fmoc-based Thiolactone Peptide Synthesis	Journal of the American Chemical Society	article	161
2016	A two-step activation mechanism controls the histone methyltransferase Suv39h1	Nature Chemical Biology	article	159
1999	Insertion of a Synthetic Peptide into a Recombinant Protein: A Protein Biosensor.	Journal of the American Chemical Society	article	156
2018	HELLS and CDCA7 comprise a bipartitie nucleosome remodeling complex defective in ICF syndrome	Proceedings of the National Academy of Sciences	article	154
2002	Autoregulation of a Bacterial Sigma Factor Explored Using Segmental Labeling and NMR	Proceedings of the National Academy of Sciences	article	154
1998	Chemical Synthesis of a Functional Circular Protein Domain: Evidence for Folding Assisted Cyclization	Angewandte Chemie International Edition	article	147
2021	Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes.	Science	article	146
2009	Structure activity analysis of semisynthetic nucleosomes: Mechanistic insights of the stimulation of Dot1L by ubiquitylated histone H2B	ACS Chemical Biology	article	143
2000	Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid phase expressed protein ligation	Chemistry & Biology	article	140
2019	Intellectual disability-associated mutations in SMARCB1 reveal a conserved coiled-coil nucleosome interaction that potentiates mSWI/SNF chromatin remodeling	Cell	article	138
1994	The Chemical Ligation of Cysteine-Containing Peptides: Synthesis of a 22 kDa Tethered Dimer of HIV- 1 Protease.	Journal of the American Chemical Society	article	136
2009	Expressed protein ligation (EPL) in the study of signal transduction, ion conduction, and chromatin biology	Accounts of Chemical Research	article	133
2000	Introduction of Unnatural Amino Acids into Proteins Using Expressed Protein Ligation	Biopolymers	article	133
1996	Mapping protein-protein interactions by affinity-directed mass spectrometry.	Proceedings of the National Academy of Sciences	article	132
2001	Rescuing a Destabilized Protein Fold Through Backbone Cyclization	Journal of Molecular Biology	article	131
2023	Tracking chromatin state changes using nanoscale photo-proximity labeling	Nature	article	130
2004	Glycine as a D-amino acid surrogate in the K+ selectivity filter.	Proceedings of the National Academy of Sciences	article	130
2007	Small Molecule-Mediated Rescue of Protein Function by an Inducible Proteolytic Shunt	Proceedings of the National Academy of Sciences	article	128
2002	Recent advances in the application of expressed protein ligation to protein engineering	Current Opinion in Biotechnology	article	128
2007	Post-translational Enzyme Activation in an Animal Via Conditional Protein Splicing	Nature Chemical Biology	article	126
2004	Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing	Proceedings of the National Academy of Sciences	article	126
2002	Reversible and specific extracellular antagonism of receptor-histidine-kinase signaling	Journal of Biological Chemistry	article	126
2012	Stability of nucleosomes containing homogeneously ubiquitylated H2A and H2B prepared using semisynthesis	Journal of the American Chemical Society	article	125
2014	Strategy for ‘detoxification’ of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2	Journal of the American Chemical Society	article	124
2019	The histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase	Proceedings of the National Academy of Sciences	article	123
2019	Identification of a DNA methyltransferase complex and the impact of N6-methyladenine on chromatin organization	Cell	article	120
2013	Extein Residues Play an Intimate Role in the Rate Limiting Step of Protein Trans-Splicing	Journal of the American Chemical Society	article	120
2008	Identification of Ligand Specificity Determinants in AgrC, the S. Aureus Quorum Sensing Receptor	Journal of Biological Chemistry	article	118
1999	Peptide Ligation and Its Application to Protein Engineering	Chemistry & Biology	article	118
2010	Chemical Approaches to Studying Histone Modifications	Journal of Biological Chemistry	article	116
1994	Design and Chemical Synthesis of a Neo-Protein Structural Model for the Cytoplasmic Domain of a Multi-Subunit Cell-Surface Receptor: Integrin IIb3 (Platelet…	Biochemistry	article	116
2013	Naturally Split Inteins Assemble through a “Capture and Collapse” Mechanism	Journal of the American Chemical Society	article	114
2021	Oncohistone mutations enhance chromatin remodeling and alter cell fate	Nature Chemical Biology	article	113
2013	Streamlined Expressed Protein Ligation Using Split Inteins	Journal of the American Chemical Society	article	113
2005	Manipulating Proteins with Chemistry: A Cross-section of Chemical Biology	Trends in Biochemical Sciences	article	113
2009	agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides	Proceedings of the National Academy of Sciences	article	111
2004	Simultaneous Triggering of Protein Activity and Fluorescence.	Journal of the American Chemical Society	article	110
2017	Ubiquitin Utilizes an Acidic Surface Patch to Alter Chromatin Structure	Nature Chemical Biology	article	108
2015	Split inteins, conjugates and uses thereof	—	article	108
2021	Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout	Proceedings of the National Academy of Sciences	article	104
2018	Functional Crosstalk between Histone H2B Ubiquitylation and H2A Modifications and Variants	Nature Communications	article	103
2017	Bisphosphoglycerate mutase controls 3-phosphoglycerate concentration and thereby serine pathway flux	Nature Chemical Biology	article	103
2018	Acetylation blocks DNA damage-induced chromatin ADP-ribosylation	Nature Chemical Biology	article	102
2003	Toward Fully Synthetic N-Linked Glycoproteins	Angewandte Chemie International Edition	article	102
2014	Structural and Dynamical Features of Inteins and Implications on Protein Splicing	Journal of Biological Chemistry	article	101
2004	Photocontrol of Smad2, a Multi-phosphorylated Cell Signaling Protein, Through Caging of Activating Phospho-serines.	Angewandte Chemie International Edition	article	101
2013	ASH2L Regulates Ubiquitylation Signaling to MLL Trans-regulation of H3 H4 Methylation in Higher Eukaryotes	Molecular Cell	article	97
2020	A basic motif anchoring ISWI to the nucleosome acidic patch regulates nucleosome spacing	Nature Chemical Biology	article	96
2020	Chromatin as a key consumer in the metabolic economy	Nature Chemical Biology	article	94
2023	A genetically encoded photoproximity labeling approach for mapping protein territories	Proceedings of the National Academy of Sciences	article	92
2011	Direct Interaction Between an Allosteric Agonist Pepducin and the Chemokine Receptor CXCR4	Journal of the American Chemical Society	article	92
2011	Kinetic Control of One-Pot Trans-Splicing Reactions Using a Wild-Type and Designed Split Intein	Angewandte Chemie International Edition	article	92
2010	Branched Intermediate Formation Stimulates Peptide Bond Cleavage in the Mxe GyrA Intein Protein Splicing Reaction	Nature Chemical Biology	article	92
2016	Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.	Nature Communications	article	91
2015	Application of the Protein Semisynthesis Strategy to the Generation of Modified Chromatin	Annual Review of Biochemistry	article	91
2015	Key driving forces in the biosynthesis of autoinducing peptides required for staphyloccal virulence.	Proceedings of the National Academy of Sciences	article	91
2011	Spreading Chromatin into Chemical Biology	ChemBioChem	article	90
2014	A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-Phase Phosphopeptide Fragmentation Mechanism	Journal of the American Chemical Society	article	88
2001	Peptide Chemical Ligation Inside Living Cells: In Vivo Generation of a Circular Protein Domain.	Bioorganic & Medicinal Chemistry	article	87
1997	Chemoselective Backbone Cyclization of Unprotected Peptides.	Chemical Communications	article	87
2020	In situ chromatin interactomics using a chemical bait & trap approach	Nature Chemistry	article	83
2006	Structural and Functional Consequences of of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.	Journal of the American Chemical Society	article	83
2008	Site Specific 18F-Labeling of the Protein Growth Hormone Leptin Using a General Two-Step Ligation Procedure	Journal of the American Chemical Society	article	82
2008	A Full Length Group 1 Bacterial Sigma Factor Adopts a Compact Structure Incompatible with DNA Binding	Chemistry & Biology	article	82
2008	Activation of Protein Splicing by Protease or Light Triggered O-N Acyl Migration	Angewandte Chemie International Edition	article	82
2000	Technical Comment - Activation and Inhibition of the Staphylococcal AGR System	Science	article	82
2018	A Chemical Probe for Protein Crotonylation	Journal of the American Chemical Society	article	81
2010	Method for the Synthesis of Mono-ADP-Ribose Conjugated Peptides	Journal of the American Chemical Society	article	80
2009	Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent	PLoS ONE	article	80
2009	A Semi-Synthetic Strategy to Generate Phosphorylated and Acetylated Histone H2B	ChemBioChem	article	79
2009	Symmetric Signaling within Asymmetric Dimers of the Staphylococcus aureus Receptor Histidine Kinase AgrC	Molecular Microbiology	article	79
1993	Chemical Synthesis of Proteins.	Current Opinion in Biotechnology	article	78
2007	Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker.	Journal of the American Chemical Society	article	76
2020	Live-cell protein engineering with an ultra-short split intein	Proceedings of the National Academy of Sciences	article	75
2020	The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma	Nature Structural & Molecular Biology	article	75
2017	Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis	Journal of the American Chemical Society	article	75
2002	Efficient Semi-synthesis of a Tetraphosphorylated Analog of the Type I TGF- Receptor	Organic Letters	article	75
2000	Semisynthesis of Hyperphosphorylated Type I TGF Receptor: Addressing the Mechanism of Kinase Activation.	Journal of the American Chemical Society	article	75
2005	A Ligation and Photorelease Strategy for the Temporal and Spatial Control of Protein Function in Living Cells	Angewandte Chemie International Edition	article	74
2021	Dot1L Complex Regulates Transcriptional Initiation in Human Erythroleukemic Cells	Proceedings of the National Academy of Sciences	article	73
2015	A Second-Generation Phosphohistidine Analog for Generation of Phosphohistidine Antibodies	Organic Letters	article	72
2013	Histone H3K27 Trimethylation Inhibits H3 Binding and Function of SET1-Like H3K4 Methyltransferase Complexes	Molecular and Cellular Biology	article	72
2025	Bidirectional histone monoaminylation dynamics regulate neural rhythmicity	Nature	article	71
2009	PET Imaging of Leptin Biodistribution and Metabolism in Rodents and Primates	Cell Metabolism	article	69
2006	Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can’t.	Current Opinion in Chemical Biology	article	69
2017	A molecular engineering toolbox for the structural biologist	Quarterly Reviews of Biophysics	article	68
2000	3-Thiopropionic Acid as a Highly Versatile Multidetactable Thioester Linker	Letters in Peptide Science	article	67
2017	Long-term hepatitis B infection in a scalable hepatic co-culture system	Nature Communications	article	66
1995	A chemical approach to the construction of multimeric protein assemblies.	Structure	article	65
2006	Solution Structure and Folding Characteristics of the C-terminal SH3 Domain of c-Crk-II.	Biochemistry	article	63
2011	Split Inteins: Nature’s Protein Ligases	Israel Journal of Chemistry	article	62
2004	Semi-synthesis of a Functional K+ Channel.	Angewandte Chemie International Edition	article	59
2021	Synthesis of ADP-Ribosylated Histones Reveals Site-Specific Impacts on Chromatin Structure and Function	Journal of the American Chemical Society	article	58
2017	Genomic targeting of epigenetic probes using a chemically tailored CRISPR/Cas9 system	Proceedings of the National Academy of Sciences	article	58
2015	Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.	Proceedings of the National Academy of Sciences	article	58
2004	Semisynthesis of Phosphovariants of SMAD2 Reveals a Substrate Preference of the Activated TR1 Kinase.	Biochemistry	article	57
2013	Induction of innate and adaptive immunity in vivo by delivery of poly dA:dT to dendritic cells	Nature Chemical Biology	article	56
2004	Activation of an Autoregulated Protein Kinase by Conditional Protein Splicing	Angewandte Chemie International Edition	article	56
2020	The chaperone FACT and histone H2B ubiquitination maintain S. pombe genome architecture through genic and subtelomeric functions	Molecular Cell	article	54
2001	Mapping the molecular surface between the 70 subunit of E.coli. RNA polymerase and T4 AsiA.	Journal of Molecular Biology	article	54
2022	Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis	Proceedings of the National Academy of Sciences	article	52
1994	Synthetic, Structural and Biological Studies of the Ubiquitin System. Part 2: Chemically Synthesised and Native Ubiquitin Fold into Identical Three-Dimensional…	Biochemical Journal	article	52
2020	H2B ubiquitylation enhances H3K4 methylation activities of human KMT2 family complexes	Nucleic Acids Research	article	51
2020	Single-molecule and in silico dissection of the of the interaction between Polycomb repressive complex 2 and chromatin	Proceedings of the National Academy of Sciences	article	51
2017	Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence.	Cell chemical biology	article	51
2009	Direct measurement of cathepsin-B activity in the cytosol of apoptotic cells by an activity based probe	Chemistry & Biology	article	49
2014	Structure of the Branched Intermediate in Protein Splicing	Proceedings of the National Academy of Sciences	article	48
2019	PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor	Proceedings of the National Academy of Sciences	article	47
1999	Chemically Synthesized Ubiquitin Extension Proteins Detect Distinct Catalytic Capacities of Deubiquitinating Enzymes.	Analytical Biochemistry	article	47
2015	Increasing AIP Macrocycle Size, Reveals Key Features of agr Activation in Staphylococcus aureus	ChemBioChem	article	46
2022	TGM2-mediated histone transglutamination is dictated by steric accessibility	Proceedings of the National Academy of Sciences	article	45
2019	Protein Engineering through Tandem Transamidation	Nature Chemistry	article	44
2019	Single-Particle Dynamic Light Scattering: Shapes of Individual Nanoparticles.	Nano Letters	article	43
2000	Synthesis of Multi-domain Proteins using Expressed Protein Ligation: Strategies for Segmental Labeling of Internal Regions.	Tetrahedron	article	43
2022	Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation	Molecular Cell	article	42
2001	Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl- terminal region of c-Crk I.	Oncogene	article	42
2012	Histone Monoubiquitination Position Determines Specificity and Direction of Enzymatic Crosstalk with Histone Methyltransferase Dot1L and PCR2	Journal of Biological Chemistry	article	40
2011	A semisynthetic Eph receptor tyrosine kinase provides insight into ligand- induced kinase activation	Chemistry & Biology	article	40
2019	Nucleic acid-barcoding technologies: converting DNA sequencing into a broad-spectrum molecular counter	Angewandte Chemie International Edition	article	39
2004	Domain Specific Incorporation of Non-Invasive Optical Probes Into Recombinant Proteins	Journal of the American Chemical Society	article	39
2025	Native nucleosomes intrinsically encode genome organization principles	Nature	article	37
2011	Tuning protein autoinhibition by domain destabilization	Nature Structural & Molecular Biology	article	37
2001	Fluorescent Monitoring of Kinase Activity in Real Time: Development of a Robust Fluorescence-based Assay for Abl Tyrosine Kinase Activity	Bioorganic & Medicinal Chemistry Letters	article	37
1998	New peptide inhibitors of HIV-1 protease and viral infection of peripheral blood lymphocytes based on HIV-1 Vif.	Proceedings of the National Academy of Sciences	article	35
2018	Improved protein splicing using embedded split inteins	Protein Science	article	34
2019	JASPer controls interphase H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila	Nature Communications	article	31
2019	Identification of a Molecular Latch that Regulates Staphylococcal Virulence	Cell chemical biology	article	30
2018	An Atypical Mechanism of Split Intein Molecular Recognition and Folding	Journal of the American Chemical Society	article	30
2017	Emerging chemistry strategies for engineering native chromatin	Journal of the American Chemical Society	article	29
2015	DNA-guided establishment of nucleosome patterns within coding regions of a eukaryotic genome.	Genome Research	article	28
2020	Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphyloccocus aureus receptor histidine kinase, AgrC.	Chemical Communications	article	27
2019	Proximity Induced Splicing Utilizing Caged Split Inteins	Journal of the American Chemical Society	article	27
2018	Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation	Nucleic Acids Research	article	27
2019	Nucleation and propagation of heterochromatin by the histone methyltransferase PRC2: geometric constraints and impact of the regulatory subunit JARID2	Journal of the American Chemical Society	article	26
2009	Semisynthesis of ubiquitylated proteins	Methods in enzymology on CD-ROM/Methods in enzymology	article	26
2007	Tunable Photoactivation of a Postranslationally Modified Signaling Protein and Its Unmodified Counterpart in Live Cells.	ChemBioChem	article	22
1997	Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids.	Biochemical Journal	article	22
2021	Engineering of a peptide α-N-methyltransferase to methylate non-proteinogenic amino acids	Angewandte Chemie International Edition	article	19
1994	Total Chemical Synthesis of a Folded -Sandwich Protein Domain: A Fibronectin Type 3 Module.	Journal of the American Chemical Society	article	19
2015	Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin	Angewandte Chemie International Edition	article	18
2001	Development and Application of Expressed Protein Ligation	Synlett	article	17
1996	Probing the Chemical Basis of Binding Activity in an SH3 Domain by Protein Signature Analysis.	Chemistry & Biology	article	17
1998	Studying Receptor-Ligand Interactions Using Encoded Amino Acid Scanning	Biochemistry	article	16
1995	Detection of Synthetic Protein Isomers & Conformers by Electrospray Mass Spectrometry.	Analytical Biochemistry	article	15
2008	An Amalgamation of Solid Phase Peptide Synthesis and Ribosomal Peptide Synthesis	Biopolymers	article	14
1997	Methods for the chemical Synthesis and Readout of Self-Encoded Arrays of Protein Analogues.	Journal of the American Chemical Society	article	14
2008	Towards the Semisynthesis of Multi-domain Trans-membrane Receptors: Modification of Eph Tyrosine Kinases	Protein Science	article	13
2020	Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia	Cell Reports	article	12
2016	Access to site-specific Fc-cRGD peptide conjugates through streamlined expressed protein ligation	Organic & Biomolecular Chemistry	article	12
1998	Adding 'Splice' to Protein Engineering	Structure	article	12
2003	“The splice is right:” how protein splicing is opening new doors in protein science.	Chemical Communications	article	11
2003	Turning Virulence On and Off in Staphylococci	Journal of Peptide Science	article	11
2006	Chemical Biology: Cutting out the middle man	Nature	article	6
2019	Determining the Spheroid Geometry of Individual Metallic Nanoparticles by Two-Dimensional Single-Particle Dynamic Light Scattering	The Journal of Physical Chemistry C	article	5
2008	Systems and molecular level elucidation of signaling processes through chemistry	Science Signaling	article	3
2003	Segmental Isotopic Labeling: Prospects for a new tool to study the structure-function relationships in multi- domain proteins.	—	article	3
2012	From EPOthilone to EPO: A Challenge for natural product synthesis	Proceedings of the National Academy of Sciences	article	2
2009	Chemical Biology in a Time of Transition	ACS Chemical Biology	article	2
2005	Award Address – Irving Sigal Young Investigator, The Protein Society	Protein Science	article	0
2020	Cancer-associated Mutations in ENL Drive Self-reinforced Chromatin Targeting and Impair Cell Differentiation	Nature	article	—
2020	A nucleosome acidic patch binder stabilized by UbH2A underlies cancer-specific mSWI/SNF chromatin remodeling activities	—	article	—
2008	2008 Vincent du Vigneaud Award Address	—	article	—
2005	Exploring Biological Function Through Chemical Manipulation of Biopolymers	Current Opinion in Chemical Biology	article	—
2002	Semi-synthesis of the potassium channel, KcsA	Biophysical Journal	article	—
2001	Learning the Language of Chemical Biology	—	article	—
1997	Capillary Electrophoresis Assay for Ubiquitin Carboxy-Terminal Hydrolases with Chemically Synthesized Ubiquitin-Valine as Substrate.	Analytical Biochemistry	article	—
1993	Ring Expansion and Rearrangement Reactions of N-Heteroarylmethyl Radicals.	Journal of the Chemical Society Chemical Communications	article	—
1993	Ubiquitin Carboxyl-terminal Hydrolases in Human Brain.	Journal of Neurochemistry	article	—
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—	Farrelly. L.A., Thompson, R.E., Zhao, S., Lepack, A.E., Lu, Y., Bhanu, N.V., Zhang, B., Loh, Y.-H. E.,	—	article	—