David W. Christianson
Academic
Totals
Coverage
Top venues 25 venues
The 8 holding the most of these works; 17 more hold at least one.
Publications per year
Works this academic published in each year, by the year each work appeared; an undated work is in no year, and a work two colleagues wrote counts for each of them. The kind, works and year filters decide which works are here at all.
Citations per year
Citations received in each year, from this academic’s verified Scholar profile, which counts every citation to everything they ever wrote: no publication filter reaches this line - not the kinds, not the works switch, not the year window on publication - and no journal weight either. It is a profile total, so it does not match the works listed below.
Publications 99 works
Every work these filters select, most cited first and the works with no count at the end: a work nobody has a figure for is unknown, never a zero to be ranked among the works that have one, and it prints an em dash. Each figure is that work’s own citations - Scholar’s count where there is one, else OpenAlex’s - and is not weighted.
| Year | Title | Venue | Kind | Citations |
|---|---|---|---|---|
| 2017 | Structural and chemical biology of terpenoid cyclases | Chemical Reviews | article | 1,406 |
| 2006 | Structural biology and chemistry of the terpenoid cyclases | Chemical Reviews | article | 955 |
| 1989 | Carboxypeptidase a | Accounts of Chemical Research | article | 905 |
| 2012 | HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle | Nature | article | 748 |
| 1996 | Carbonic anhydrase: evolution of the zinc binding site by nature and by design | Accounts of Chemical Research | article | 629 |
| 2016 | Histone deacetylase 6 structure and molecular basis of catalysis and inhibition | Nature Chemical Biology | article | 606 |
| 1991 | Structural biology of zinc | Advances in protein chemistry | article | 597 |
| 1997 | Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology | Science | article | 565 |
| 1996 | Structure of a unique binuclear manganese cluster in arginase | Nature | article | 558 |
| 1999 | Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes | Annual Review of Biochemistry | article | 479 |
| 2001 | Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells | Proceedings of the National Academy of Sciences | article | 440 |
| 2011 | Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis | Nature | article | 426 |
| 2002 | Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase | Proceedings of the National Academy of Sciences | article | 419 |
| 2008 | Unearthing the roots of the terpenome | Current Opinion in Chemical Biology | article | 389 |
| 2011 | Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes | Current Opinion in Structural Biology | article | 381 |
| 1990 | Hydrogen bond stereochemistry in protein structure and function | Journal of Molecular Biology | article | 373 |
| 2001 | Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade | Proceedings of the National Academy of Sciences | article | 348 |
| 2009 | Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats | Journal of Applied Physiology | article | 313 |
| 2008 | Endothelial arginase II: a novel target for the treatment of atherosclerosis | Circulation Research | article | 304 |
| 1999 | Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase | Proceedings of the National Academy of Sciences | article | 288 |
| 1997 | Structural chemistry and biology of manganese metalloenzymes | — | article | 280 |
| 1991 | Unexpected pH-dependent conformation of His-64, the proton shuttle of carbonic anhydrase II | Journal of the American Chemical Society | article | 275 |
| 2017 | ARID1A-mutated ovarian cancers depend on HDAC6 activity | Nature Cell Biology | article | 271 |
| 2007 | Inducible NO Synthase–Dependent S-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction | Circulation Research | article | 252 |
| 2008 | Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors, | Biochemistry | article | 251 |
| 1998 | Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA | Proceedings of the National Academy of Sciences | article | 248 |
| 2004 | Structure of Human Epoxide Hydrolase Reveals Mechanistic Inferences on Bifunctional Catalysis in Epoxide and Phosphate Ester Hydrolysis, | Biochemistry | article | 238 |
| 1994 | Two-site binding of phenol in the active site of human carbonic anhydrase II: structural implications for substrate association | Journal of the American Chemical Society | article | 238 |
| 1994 | Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop | Nature Structural Biology | article | 238 |
| 2005 | Crystal structure of human arginase I at 1.29-Å resolution and exploration of inhibition in the immune response | Proceedings of the National Academy of Sciences | article | 237 |
| 2017 | Histone deacetylase 10 structure and molecular function as a polyamine deacetylase | Nature Communications | article | 233 |
| 2000 | Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti | Journal of Biological Chemistry | article | 224 |
| 1999 | Arginase–boronic acid complex highlights a physiological role in erectile function | Nature Structural Biology | article | 224 |
| 1998 | Ribonuclease P protein structure: evolutionary origins in the translational apparatus | Science | article | 223 |
| 2001 | Probing Erectile Function: S-(2-Boronoethyl)-l-Cysteine Binds to Arginase as a Transition State Analogue and Enhances Smooth Muscle Relaxation in Human Penile … | Biochemistry | article | 222 |
| 2008 | Arginase and vascular aging | Journal of Applied Physiology | article | 219 |
| 2011 | Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase | Nature Chemical Biology | article | 218 |
| 2014 | Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked … | Human Molecular Genetics | article | 215 |
| 1989 | Carboxylate-histidine-zinc interactions in protein structure and function | Journal of the American Chemical Society | article | 213 |
| 2017 | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors | Proceedings of the National Academy of Sciences | article | 210 |
| 1991 | Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121. | Journal of Biological Chemistry | article | 207 |
| 2003 | Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis | Proceedings of the National Academy of Sciences | article | 205 |
| 1996 | Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-Å resolution | Proceedings of the National Academy of Sciences | article | 203 |
| 2011 | Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases | Journal of the American Chemical Society | article | 200 |
| 2002 | Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis | Journal of the American Chemical Society | article | 200 |
| 2005 | Arginase: structure, mechanism, and physiological role in male and female sexual arousal | Accounts of Chemical Research | article | 196 |
| 2003 | Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal, | Biochemistry | article | 193 |
| 1993 | Purification and characterization of Klebsiella aerogenes UreE protein: A nickel‐binding protein that functions in urease metallocenter assembly | Protein Science | article | 192 |
| 2010 | Structure of epi-isozizaene synthase from Streptomyces coelicolor A3 (2), a platform for new terpenoid cyclization templates | Biochemistry | article | 188 |
| 2009 | Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase | Journal of the American Chemical Society | article | 186 |
| 2007 | X-ray crystal structure of aristolochene synthase from Aspergillus terreus and the evolution of templates for the cyclization of farnesyl diphosphate | Biochemistry | article | 178 |
| 2000 | Contribution of fluorine to protein− ligand affinity in the binding of fluoroaromatic inhibitors to carbonic anhydrase II | Journal of the American Chemical Society | article | 176 |
| 1997 | Inhibition of Mn2+2-Arginase by Borate Leads to the Design of a Transition State Analogue Inhibitor, 2(S)-Amino-6-boronohexanoic Acid | Journal of the American Chemical Society | article | 176 |
| 2010 | Trinuclear metal clusters in catalysis by terpenoid synthases | — | article | 172 |
| 2019 | Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases | Current Opinion in Structural Biology | article | 168 |
| 2010 | Arginase I suppresses IL-12/IL-23p40–driven intestinal inflammation during acute schistosomiasis | The Journal of Immunology | article | 168 |
| 2000 | Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation | Journal of Biological Chemistry | article | 165 |
| 1998 | Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism | Current Opinion in Structural Biology | article | 160 |
| 1986 | X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature. | Proceedings of the National Academy of Sciences | article | 157 |
| 1995 | X-ray crystallographic studies of engineered hydrogen bond networks in a protein-zinc binding site | Journal of the American Chemical Society | article | 156 |
| 1994 | Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in t… | Journal of Medicinal Chemistry | article | 154 |
| 1995 | Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants | Journal of Medicinal Chemistry | article | 151 |
| 2000 | Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase | Journal of Biological Chemistry | article | 150 |
| 1995 | Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design. | Proceedings of the National Academy of Sciences | article | 149 |
| 2004 | Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV | Journal of Biological Chemistry | article | 143 |
| 1993 | Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II. | Journal of Biological Chemistry | article | 142 |
| 2009 | Crystal structure of (+)-δ-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis | Biochemistry | article | 139 |
| 1997 | Novel binding mode of hydroxamate inhibitors to human carbonic anhydrase II | Journal of the American Chemical Society | article | 139 |
| 1996 | Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II | Biochemistry | article | 139 |
| 2010 | Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission | Journal of Molecular Biology | article | 136 |
| 1997 | Histidine→ carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity | Biochemistry | article | 134 |
| 2008 | Directing noble metal ion chemistry within a designed ferritin protein | Biochemistry | article | 132 |
| 2007 | Roots of biosynthetic diversity | Science | article | 132 |
| 2013 | Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in c… | Journal of Medicinal Chemistry | article | 131 |
| 1998 | Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme‐drug discrimination | Protein Science | article | 131 |
| 2006 | Human soluble epoxide hydrolase: Structural basis of inhibition by 4‐(3‐cyclohexylureido)‐carboxylic acids | Protein Science | article | 130 |
| 1991 | Engineering the hydrophobic pocket of carbonic anhydrase II | Biochemistry | article | 130 |
| 1998 | Structural analysis of inhibitor binding to human carbonic anhydrase II | Protein Science | article | 124 |
| 2002 | Combinatorial computational method gives new picomolar ligands for a known enzyme | Proceedings of the National Academy of Sciences | article | 123 |
| 2003 | Arginase and autoimmune inflammation in the central nervous system | — | article | 119 |
| 2000 | Arginase: a binuclear manganese metalloenzyme | — | article | 119 |
| 2019 | Synthesis and biological investigation of phenothiazine-based benzhydroxamic acids as selective histone deacetylase 6 inhibitors | Journal of Medicinal Chemistry | article | 118 |
| 1991 | Biological recognition of phosphate and sulfate | Journal of Biological Chemistry | article | 117 |
| 2018 | Histone deacetylase 6-selective inhibitors and the influence of capping groups on hydroxamate-zinc denticity | Journal of Medicinal Chemistry | article | 116 |
| 2002 | Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle | Biochemistry | article | 116 |
| 2021 | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites | Nature Communications | article | 115 |
| 1997 | Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function | Biochemistry | article | 114 |
| 1987 | Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue. | Proceedings of the National Academy of Sciences | article | 113 |
| 1986 | Complex between carboxypeptidase A and a possible transition-state analog: mechanistic inferences from high-resolution x-ray structures of enzyme-inhibitor com… | Journal of the American Chemical Society | article | 112 |
| 2001 | Mechanistic and Metabolic Inferences from the Binding of Substrate Analogues and Products to Arginase, | Biochemistry | article | 111 |
| 2006 | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with “two-prong” inhibitors reveal the molecular basis of high affinity | Journal of the American Chemical Society | article | 108 |
| 2002 | X-ray Crystal Structures of D100E Trichodiene Synthase and Its Pyrophosphate Complex Reveal the Basis for Terpene Product Diversity, | Biochemistry | article | 107 |
| 2001 | Fluoroaromatic− Fluoroaromatic Interactions between Inhibitors Bound in the Crystal Lattice of Human Carbonic Anhydrase II | Journal of the American Chemical Society | article | 106 |
| 2013 | Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections | Nitric Oxide | article | 104 |
| 2010 | Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function | Biochemistry | article | 103 |
| 1990 | Stereochemistry of phosphate-Lewis acid interactions: implications for nucleic acid structure and recognition | Journal of the American Chemical Society | article | 101 |
| 1999 | Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor | Journal of Pharmacology and Experimental Therapeutics | article | 100 |
| 1996 | Structure-based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-based biosensor | Journal of the American Chemical Society | article | 100 |
| 1991 | Conformational mobility of His-64 in the Thr-200. fwdarw. Ser mutant of human carbonic anhydrase II | Biochemistry | article | 100 |