Academics · Demo University

Analytics Database

Search filters

Field Chemistry

Chemistry English Political Science

University any

All

Brown Columbia Cornell Dartmouth Harvard Penn Princeton Yale

Years all years

5y 10y All

Publication type 3 of 8

All

articles books edited volumes chapters conference papers reports reviews other works

Academic rank any

All

Works CV or Scholar

CV Scholar

Journal tier any

All

A* A B unranked

How a figure is made

Citation weight off, every journal counts 1. Change it

Department formula mean * log(1 + people). Change it

Back to the list

Academic

David R. Liu

Academic

RankDistinguished

As of2019 · CV

DepartmentHarvard Chemistry

UniversityHarvard

FieldChemistry

ORCID0000-0002-9943-7557

Scholarprofile

Totals

Publications324

Citations102,025

h-index178 · Scholar

Citations per year in post3,778.7

Years in post27 from the CV positions

Coverage

Works with a count99 of 324

Share31%

Positions

Thomas Dudley Cabot Professor of the Natural…2019–

Richard Merkin Professor, Broad Institute of…2017–

Director of the Merkin Institute of Transform…2017–

Associate Faculty Member, Wyss Institute for…2016–2017

Core Institute Member, Broad Institute of Har…2016–

Vice-Chair of the Faculty, Broad Institute of…2016–

Director, Chemical Biology and Therapeutics S…2016–

Institute Member, Broad Institute of Harvard…2015–2016

and 10 more

Top venues 69 venues

The 8 holding the most of these works; 61 more hold at least one.

Nature Biotechnology36

Journal of the American Chemical Society35

Nature Communications26

Nature19

Nature Chemical Biology18

Proceedings of the National Academy of Scienc…17

Chemistry & Biology12

Cell11

Publications per year

Works this academic published in each year, by the year each work appeared; an undated work is in no year, and a work two colleagues wrote counts for each of them. The kind, works and year filters decide which works are here at all.

Citations per year

Citations received in each year, from this academic’s verified Scholar profile, which counts every citation to everything they ever wrote: no publication filter reaches this line - not the kinds, not the works switch, not the year window on publication - and no journal weight either. It is a profile total, so it does not match the works listed below.

Publications 324 works

Every work these filters select, most cited first and the works with no count at the end: a work nobody has a figure for is unknown, never a zero to be ranked among the works that have one, and it prints an em dash. Each figure is that work’s own citations - Scholar’s count where there is one, else OpenAlex’s - and is not weighted.

Year	Title	Venue	Kind	Citations
2009	Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Fusion Partner, TET1	Science	article	7,208
2016	Programmable Editing of a Target Base in Genomic DNA Without Double-Stranded DNA Cleavage	Nature	article	7,157
2019	Search-and-Replace Genome Editing Without Double-Strand Breaks or Donor DNA	Nature	article	6,222
2017	Programmable Base Editing of A•T to G•C in Genomic DNA Without DNA Cleavage	Nature	article	5,394
2004	Scaling of theory‐of‐mind tasks	Child Development	article	3,397
2020	Genome Editing with CRISPR-Cas Nucleases, Base Editors, Transposases, and Prime Editors	Nature Biotechnology	article	2,769
2007	DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists	Nucleic Acids Research	article	2,533
2018	Base Editing: Precision Chemistry on the Genome and Transcriptome of Living Cells	Nature Reviews Genetics	article	2,184
2013	High-Throughput Profiling of Off-Target DNA Cleavage Reveals RNA-Programmed Cas9 Nuclease Specificity	Nature Biotechnology	article	2,121
2018	Evolved Cas9 Variants with Broad PAM Compatibility and High DNA Specificity	Nature	article	2,051
2019	CRISPResso2 provides accurate and rapid genome editing sequence analysis	Nature Biotechnology	article	1,940
2017	AACR Project GENIE: powering precision medicine through an international consortium	Cancer Discovery	article	1,868
2015	Cationic Lipid-Mediated Delivery of Proteins Enables Efficient Protein-Based Genome Editing In Vitro and In Vivo	Nature Biotechnology	article	1,862
2014	Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy…	The Lancet Oncology	article	1,815
2013	Sequence-Controlled Polymers	Science	article	1,593
2017	CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes	Cell	article	1,497
2015	Methods for the Directed Evolution of Proteins	Nature Reviews Genetics	article	1,438
2014	Fusion of Catalytically Inactive Cas9 to FokI Nuclease Improves the Specificity of Genome Modification	Nature Biotechnology	article	1,276
2020	Phage-Assisted Evolution of an Adenine Base Editor with Enhanced Cas Domain Compatibility and Activity	Nature Biotechnology	article	1,274
2018	Improving Cytidine and Adenine Base Editors by Expression Optimization and Ancestral Reconstruction	Nature Biotechnology	article	1,169
2019	Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma	Nature Medicine	article	1,116
2011	A System for the Continuous Directed Evolution of Biomolecules	Nature	article	1,090
2017	Improved Base Excision Repair Inhibition and Bacteriophage Mu Gam Protein Yields C:G-to-T:A Base Editors with Higher Efficiency and Product Purity	Science Advances	article	1,055
2017	Increasing the Genome-Targeting Scope and Precision of Base Editing with Engineered Cas9-Cytidine Deaminase Fusions	Nature Biotechnology	article	1,052
2020	Prime Genome Editing in Rice and Wheat	Nature Biotechnology	article	1,037
2009	A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog	Cell stem cell	article	1,036
2018	The long tail of oncogenic drivers in prostate cancer	Nature Genetics	article	1,030
2004	Hand-held thoracic sonography for detecting post-traumatic pneumothoraces: the Extended Focused Assessment with Sonography for Trauma (EFAST)	—	article	989
2021	Enhanced Prime Editing Systems by Manipulating Cellular Determinants of Editing Outcomes	Cell	article	985
2010	The Behavior of 5-Hydroxymethylcytosine in Bisulfite Sequencing	PLoS ONE	article	944
2016	Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein	Molecular Cell	article	928
2013	Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-F…	Journal of Clinical Oncology	article	923
2022	Engineered pegRNAs Improve Prime Editing Efficiency	Nature Biotechnology	article	890
2020	A Bacterial Cytidine Deaminase Toxin Enables CRISPR-Free Mitochondrial Base Editing	Nature	article	886
2011	A General Strategy for the Evolution of Bond-Forming Enzymes Using Yeast Display	Proceedings of the National Academy of Sciences	article	758
2022	Engineered Virus-Like Particles for Efficient In Vivo Delivery of Therapeutic Proteins	Cell	article	757
2022	Programmable Deletion, Replacement, Integration, and Inversion of Large DNA Sequences with Twin Prime Editing	Nature Biotechnology	article	756
2016	Efficient Delivery of Genome-Editing Proteins using Bioreducible Lipid Nanoparticles	Proceedings of the National Academy of Sciences	article	742
2003	ERKMAPK activity as a determinant of tumor growth and dormancy; regulation by p38SAPK	Cancer Research	article	738
2018	Predictable and Precise Template-Free CRISPR Editing of Pathogenic Variants	Nature	article	733
2015	A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo	Science Translational Medicine	article	732
2005	Steps in theory-of-mind development for children with deafness or autism	Child Development	article	728
2013	Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase II…	Journal of Clinical Oncology	article	709
2007	Supercharging Proteins Can Impart Extraordinary Resilience	Journal of the American Chemical Society	article	697
2011	Revealing Off-Target Cleavage Specificities of Zinc Finger Nucleases by In Vitro Selection	Nature Methods	article	694
2008	Theory of mind development in Chinese children: a meta-analysis of false-belief understanding across cultures and languages.	Developmental Psychology	article	679
2018	Treatment of Autosomal Dominant Hearing Loss by In Vivo Delivery of Genome Editing Agents	Nature	article	663
2019	Adopt a Moratorium on Heritable Genome Editing	Nature	article	661
2007	DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis	BMC Bioinformatics	article	649
2018	Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors	Nature Genetics	article	645
2004	DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles	Science	article	635
2007	Multi-institutional clinical experience with the Calypso System in localization and continuous, real-time monitoring of the prostate gland during external radi…	International Journal of Radiation OncologyBiologyPhysics	article	608
2022	Therapeutic In Vivo Delivery of Gene Editing Agents	Cell	article	591
2020	Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors	Nature Biotechnology	article	587
2017	Improving the DNA Specificity and Applicability of Base Editing Through Protein Engineering and Protein Delivery In Vitro and In Vivo	Nature Communications	article	584
2001	Urokinase Receptor and Fibronectin Regulate the ERKMAPK to p38MAPK Activity Ratios That Determine Carcinoma Cell Proliferation or Dormancy In Vivo	Molecular Biology of the Cell	article	584
2021	In Vivo Base Editing Rescues Hutchinson-Gilford Progeria Syndrome in Mice	Nature	article	573
2020	Cytosine and Adenine Base Editing of the Brain, Liver, Retina, Heart and Skeletal Muscle of Mice Via Adeno-Associated Viruses	Nature Biomedical Engineering	article	573
2021	Biologically informed deep neural network for prostate cancer discovery	Nature	article	567
2006	Scaling of theory-of-mind understandings in Chinese children	Psychological Science	article	561
2015	Small Molecule-Triggered Cas9 Protein with Improved Genome-Editing Specificity	Nature Chemical Biology	article	560
2000	Enzyme Mechanisms for Polycyclic Triterpene Formation	Angewandte Chemie International Edition	article	552
2011	Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study	Journal of Antimicrobial Chemotherapy	article	551
2019	AUGMENT: a phase III study of lenalidomide plus rituximab versus placebo plus rituximab in relapsed or refractory indolent lymphoma	Journal of Clinical Oncology	article	547
2009	Photoswitching mechanism of cyanine dyes	Journal of the American Chemical Society	article	525
2002	EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma	Cancer Cell	article	518
2021	Base Editing of Hematopoietic Stem Cells Rescues Sickle Cell Disease in Mice	Nature	article	487
2018	Rituximab plus lenalidomide in advanced untreated follicular lymphoma	New England Journal of Medicine	article	475
2020	Continuous Evolution of SpCas9 Variants Compatible with Non-G PAMs	Nature Biotechnology	article	470
2019	Continuous Evolution of Base Editors with Expanded Target Compatibility and Improved Activity	Nature Biotechnology	article	459
1999	Progress Towards the Evolution of an Organism with an Expanded Genetic Code	Proceedings of the National Academy of Sciences	article	458
2006	The Pathogen-Associated iroA Gene Cluster Mediates Bacterial Evasion of Lipocalin 2	Proceedings of the National Academy of Sciences	article	449
2025	Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease	New England Journal of Medicine	article	441
2018	The 2018 ISDE achalasia guidelines	Diseases of the Esophagus	article	419
2006	How Pathogenic Bacteria Evade Mammalian Sabotage in the Battle for Iron	Nature Chemical Biology	article	412
2001	The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules	Journal of the American Chemical Society	article	398
2004	Reaction Discovery Enabled by DNA-Templated Synthesis and In Vitro Selection	Nature	article	388
2021	Massively Parallel Assessment of Human Variants with Base Editor Screens	Cell	article	384
2023	Phage-Assisted Evolution and Protein Engineering Yield Compact, Efficient Prime Editors	Cell	article	380
2009	Mammalian Cell Penetration, siRNA Transfection, and DNA Transfection by Supercharged Proteins	Proceedings of the National Academy of Sciences	article	367
2020	Programmable m6A Modification of Cellular RNA with a Cas13-Directed Methyltransferase	Nature Biotechnology	article	363
2020	Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning	Cell	article	362
2019	Analysis and Minimization of Cellular RNA Editing by DNA Adenine Base Editors	Science Advances	article	359
2011	Opposing Effects of Tcf3 and Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal	Nature Cell Biology	article	359
2017	Continuous Directed Evolution of Aminoacyl-tRNA Synthetases	Nature Chemical Biology	article	357
2019	Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors	Nature Biotechnology	article	351
1997	Engineering a tRNA and Aminoacyl-tRNA Synthetase for the Site-Specific Incorporation of Unnatural Amino Acids into Proteins in Vivo	Proceedings of the National Academy of Sciences	article	349
2024	Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours	Nature reviews. Cancer	article	341
2012	On-chip transformation optics for multimode waveguide bends	Nature Communications	article	340
2014	Broad Specificity Profiling of TALENs Results in Engineered Nucleases with Improved DNA Cleavage Specificity	Nature Methods	article	333
2018	Rewritable Multi-Event Analog Recording in Bacterial and Mammalian Cells	Science	article	330
2014	Anti-Diabetic Activity of Insulin-Degrading Enzyme Inhibitors Mediated by Multiple Hormones	Nature	article	259
2011	Small-Molecule Discovery from DNA-Encoded Chemical Libraries	Chemical Society Reviews	article	236
2010	In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors	Journal of the American Chemical Society	article	157
2008	DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes	Journal of the American Chemical Society	article	150
2010	An In Vitro Translation, Selection and Amplification System for Peptide Nucleic Acid	Nature Chemical Biology	article	90
2012	Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles	Nature Chemical Biology	article	62
2006	Enzymatic Tailoring of Enterobactin Alters Membrane Partitioning and Iron Acquisition	ACS Chemical Biology	article	51
2026	AI-guided Re-design of Laboratory-Evolved Reverse Transcriptases Enhances Prime Editing in Human Cells and in Animals	Nature Biotechnology	article	3
2026	Mechanistic Machine Learning for Prediction of Prime Editing Outcomes	Nature Biotechnology	article	—
2026	Efficient Prime Editing In Vivo and In Vitro Using Lipid Nanoparticles	Nature Nanotechnology	article	—
2026	Evolution of Botulinum Neurotoxin Serotype X Proteases to Induce Inflammatory Cell Death in Cancer Cells	Nature Biotechnology	article	—
2026	Small-Molecule Binding and Sensing with a Designed Protein Family	Nature Communications	article	—
2026	Directed Evolution of Small RNA-Stabilizing Motifs that Improve Prime Editing	Nature Biotechnology	article	—
2026	Synonymous Editing Alters Ion Channel Function, Favoring Prime Editing for Retinal Disease Correction	—	article	—
2026	A Combinatorial Synthetic Strategy for Developing Genome-Editing Protein-Delivery Agents Targeting Mouse Retina	Nature Communications	article	—
2026	In Vivo Base Editing Rescues Liver Pathophysiology and Peroxisome Dysfunction in a Mouse Model of Zellweger Spectrum Disorder	Nature Biomedical Engineering	article	—
2026	Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model	Molecular Therapy	article	—
2026	Virus-like Particles Enable Targeted Gene Engineering and Pooled CRISPR Screening in Primary Human Myeloid Cells	Nature Biotechnology	article	—
2026	In Vivo Adenine Base Editing Ameliorates Dravet Syndrome Phenotypes in a Mouse Model	Science Translational Medicine	article	—
2026	AI-redesigned Starting Points and Outcomes Enhance Protein Evolution	Nature	article	—
2025	Systematic Optimization of Prime Editing for the Efficient Functional Correction of CFTR F508del in Human Airway Epithelial Cells	Nature Biomedical Engineering	article	—
2025	In Vivo Prime Editing Rescues Alternating Hemiplegia of Childhood in Mice	Cell	article	—
2025	EvoAI Enables Extreme Compression and Reconstruction of the Protein Sequence Space	Nature Methods	article	—
2025	Ultrasmall Chemogenetic Tags with Group-Transfer Ligands	Angewandte Chemie International Edition	article	—
2025	Branched, Chemically Modified Poly(A) Tails Enhance the Translation Capacity of mRNA	Nature Biotechnology	article	—
2025	In Vivo Base Editing of Angptl3 via Lipid Nanoparticles to Treat Cardiovascular Disease	Molecular Therapy — Nucleic Acids	article	—
2025	In Vivo Base Editing Extends Lifespan of a Humanized Mouse Model of Prion Disease	Nature Medicine	article	—
2025	GFP-on Mouse Model for Interrogation of In Vivo Gene Editing	Nature Communications	article	—
2025	A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies	Journal of the American Chemical Society	article	—
2025	Engraftment and Persistence of HBB Base-Edited Hematopoietic Stem Cells in Nonhuman Primates	Science Translational Medicine	article	—
2025	Directed Evolution of Engineered Virus-Like Particles with Improved Production and Transduction Efficiencies	Nature Biotechnology	article	—
2025	TIGER: A Novel tdTomato In-Vivo Genome-Editing Reporter Mouse for Investigating Precision-Editor Delivery Approaches	Proceedings of the National Academy of Sciences	article	—
2025	Correcting a Pathogenic Mitochondrial DNA Mutation by Base Editing in Mice	Science Translational Medicine	article	—
2025	Efficient Site-Specific Integration of Large Genes in Mammalian Cells Via Continuously Evolved Recombinases and Prime Editing	Nature Biomedical Engineering	article	—
2025	Safer and Efficient Base Editing and Prime Editing Via Ribonucleoproteins Delivered Through Optimized Lipid-Nanoparticle Formulations	Nature Biomedical Engineering	article	—
2025	Scalable Purification Enables High-Quality Virus-Like Particles for Therapeutic Translation	Journal of Biological Chemistry	article	—
2025	High Throughput Evaluation of Genetic Variants with Prime Editing Sensor Libraries	Nature Biotechnology	article	—
2025	Precisely Defining Disease Variant Effects in CRISPR-Edited Single Cells	Nature	article	—
2025	Systematic Empirical Evaluation of Individual Base Editing Targets: Validating Therapeutic Targets in USH2A and Comparison of Methods	Molecular Therapy	article	—
2025	Adenine Base Editing Rescues Pathogenic Phenotypes in Tissue Engineered Vascular Model of Hutchinson-Gilford Progeria Syndrome	—	article	—
2025	In Vivo Prime Editing Rescues Photoreceptor Degeneration in Nonsense Mutant Retinitis Pigmentosa	Nature Communications	article	—
2025	Prime Editing-Installed Suppressor tRNAs for Disease-Agnostic Genome Editing	Nature	article	—
2025	Programmable Gene Insertion in Human Cells with a Laboratory-Evolved CRISPR-Associated Transposase	Science	article	—
2025	Modulating Collagen I Expression in Fibroblasts by CRISPR-Cas9 Base Editing of the Collagen 1A1 Promoter	International Journal of Molecular Sciences	article	—
2025	Multiplex Base Editing to Protect from CD33 Directed Drugs for Immune and Gene Therapy	Nature Communications	article	—
2024	Efficient Prime Editing in Mouse Brain, Liver and Heart with Dual AAVs	Nature Biotechnology	article	—
2024	Twin Prime Editing Mediated Exon Skipping for restored Collagen VII Expression in Recessive Dystrophic Epidermolysis Bullosa	Journal of Investigative Dermatology	article	—
2024	Amphiphilic Shuttle Peptide Delivers Base Editor Ribonucleoprotein to Correct the CFTR R553X Mutation in Well-Differentiated Airway Epithelial Cells	Nucleic Acids Research	article	—
2024	In Vivo Photoreceptor Base Editing Ameliorates Rhodopsin-E150K Autosomal-Recessive Retinitis Pigmentosa in Mice	Proceedings of the National Academy of Sciences	article	—
2024	Post-Translational Modification-Centric Base Editor Screens to Assess Phosphorylation Site Functionality In High-Throughput	Nature Methods	article	—
2024	Adenine Transversion Editors Enable Precise, Efficient A•T-To-C•G Base Editing in Mammalian Cells and Embryos	Nature Biotechnology	article	—
2024	Introducing a Hemoglobin G-Makassar Variant in HSCs by In Vivo Base Editing Treats Sickle Cell Disease in Mice	Molecular Therapy	article	—
2024	Engineered Virus-Like Particles for Transient Delivery of Prime Editor Ribonucleoprotein Complexes In Vivo	Nature Biotechnology	article	—
2024	Efficient Prime Editing in Two-Cell Mouse Embryos Using PEmbryo	Nature Biotechnology	article	—
2024	Bone Marrow Homing Lipid Nanoparticles for Genome Editing in Diseased and Malignant Hematopoietic Stem Cells	Nature Nanotechnology	article	—
2024	Phage-Assisted Evolution of Highly Active Cytosine Base Editors with Enhanced Selectivity and Minimal Sequence Context Preference	Nature Communications	article	—
2024	Self-Delivering CRISPR RNAs for AAV Co-Delivery and Genome Editing In Vivo	Nucleic Acids Research	article	—
2024	A Prime Editor Mouse to Model a Broad Spectrum of Somatic Mutations In Vivo	Nature Biotechnology	article	—
2024	Continuous Evolution of Compact Protein Degradation Tags Regulated by Selective Cereblon Molecular Glues	Science	article	—
2024	Proteolysis Targeting Chimeras With Reduced Off-Targets	Nature Chemistry	article	—
2023	Treatment of Monogenic and Digenic Dominant Genetic Hearing Loss by CRISPR-Cas9 Ribonucleoprotein Delivery In Vivo	Nature Communications	article	—
2023	Base Editing Rescue of Spinal Muscular Atrophy in Cells and in Mice	Science	article	—
2023	High-Throughput Continuous Evolution of Compact Cas9 Variants Targeting Single-Nucleotide-Pyrimidine PAMs	Nature Biotechnology	article	—
2023	Human T Cell Generation Is Restored in CD3d Severe Combined Immunodeficiency Through Adenine Base Editing	Cell	article	—
2023	Assigning Functionality to Cysteines by Base Editing of Cancer Dependency Genes	Nature Chemical Biology	article	—
2023	Efficient In Vivo Genome Editing Prevents Hypertrophic Cardiomyopathy in Mice	Nature Medicine	article	—
2023	Nonviral Base Editing of KCNJ13 Mutation Preserves Vision in a Model of Inherited Retinal Channelopathy.	Journal of Clinical Investigation	article	—
2023	Potent and Uniform Fetal Hemoglobin Induction Via Base Editing	Nature Genetics	article	—
2023	In Vivo HSC Prime Editing Rescues Sickle Cell Disease in a Mouse Model	Blood	article	—
2023	Evolution of an Adenine Base Editor into a Small, Efficient Cytosine Base Editor with Low Off-Target Activity	Nature Biotechnology	article	—
2023	Massively Parallel Base Editing to Map Variant Effects in Human Hematopoiesis	Cell	article	—
2023	Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo	Nature Communications	article	—
2023	Rescue of Hearing by Adenine Base Editing in a Humanized Mouse Model of Usher Syndrome Type 1F	Molecular Therapy	article	—
2023	Ex Vivo Prime Editing of Patient Hematopoietic Stem Cells Rescues Sickle-Cell Disease Phenotypes After Engraftment in Mice	Nature Biomedical Engineering	article	—
2023	Reciprocal Mutations of Lung Tropic AAV Capsids Lead to Improved Transduction Properties	—	article	—
2023	Protospacer Modification Improves Base Editing of a Canonical Splice Site Variant and Recovery of CFTR Function in Human Airway Epithelial Cells	Molecular Therapy — Nucleic Acids	article	—
2022	ABE8e Adenine Base Editor Precisely and Efficiently Corrects a Recurrent COL7A1 Nonsense Mutation	Scientific Reports	article	—
2022	Designing and Executing Prime Editing Experiments in Mammalian Cells	Nature Protocols	article	—
2022	Disruption of HIV-1 Co-Receptors CCR5 and CXCR4 in Primary Human T Cells and Hematopoietic Stem and Progenitor Cells Using Base Editing	Molecular Therapy	article	—
2022	In Vivo Base Editing Rescues Cone Photoreceptors in a Mouse Model of Early-Onset Inherited Retinal Degeneration	Nature Communications	article	—
2022	Anderson, A. K.; Koob, T.; Huang, L.; Wang, H.; Kiem, H.-P.; Liu, D. R.; Yannaki, E.; Lieber, A. J. Clin.	—	article	—
2022	Prioritization of Autoimmune Disease-Associated Genetic Variants that Perturb Regulatory Element Activity in T Cells	Nature Genetics	article	—
2022	Compact Zinc Finger Base Editors that Edit Mitochondrial or Nuclear DNA In Vitro and In Vivo	Nature Communications	article	—
2022	Precision Genome Editing in the Eye	Proceedings of the National Academy of Sciences	article	—
2022	Efficient In Vivo Delivery of a Suite of Adenine Base Editors with Single Adeno-Associated Viruses with Size-Optimized Genomes Encoding Compact Adenine Base Ed…	Nature Biomedical Engineering	article	—
2022	Generating Experimentally Unrelated Target Molecule-Binding Highly Functionalized Nucleic Acid Polymers Using Machine Learning	Nature Communications	article	—
2022	Discovery and Molecular Basis of Subtype-Selective Cyclophilin Inhibitors	Nature Chemical Biology	article	—
2022	CRISPR-Free Base Editors with Enhanced Activity and Expanded Targeting Scope in Mitochondrial and Nuclear DNA	Nature Biotechnology	article	—
2022	Efficient and Scalable Process to Produce Novel and Highly Bioactive Purified Cytosolic Crystals from Bacillus thuringiensis	Microbiology Spectrum	article	—
2021	Restoration of Visual Function in Adult Mice with an Inherited Retinal Disease via Adenine Base Editing	Nature Biomedical Engineering	article	—
2021	Precision Genome Editing Using Cytosine and Adenine Base Editors	Nature Protocols	article	—
2021	PrimeDesign Software for Rapid and Simplified Design of Prime Editing Guide RNAs	Nature Communications	article	—
2021	Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression	Genome biology	article	—
2021	In Vivo Somatic Cell Base Editing and Prime Editing	Molecular Therapy	article	—
2021	Efficient C•G-to-G•C Base Editors Developed Using CRISPRi Screens, Target-Library Analysis and Machine Learning	Nature Biotechnology	article	—
2021	Mechanisms of Angiogenic Incompetence in iPSC-Derived Endothelial Cells of Hutchinson-Gilford Progeria Syndrome via Downregulation of Endothelial Nitric Oxide…	—	article	—
2021	Laboratory Evolution of a Sortase Enzyme that Modifies Amyloid-β Protein	Nature Chemical Biology	article	—
2021	Phage-Assisted Evolution of Selective Botulinum Neurotoxin Proteases with Reprogrammed Substrate Specificity	Science	article	—
2021	The NIH Somatic Cell Genome Editing Program	Nature	article	—
2021	Disulfide-Compatible Phage-Assisted Continuous Evolution in the Periplasmic Space	Nature Communications	article	—
2021	Reconstruction of Evolving Gene Variants and Fitness from Short Sequencing Reads	Nature Chemical Biology	article	—
2021	Functional Correction of CFTR Mutations in Human Airway Epithelial Cells using Adenine Base Editors	Nucleic Acids Research	article	—
2020	Multimodal Small-Molecule Screening for Human Prion Protein Binders	Journal of Biological Chemistry	article	—
2020	In Vivo Base Editing Restores Sensory Transduction and Transiently Improves Auditory Function in a Mouse Model of Recessive Deafness	Science Translational Medicine	article	—
2020	Chemical Modifications of Adenine Base Editor mRNA and Guide RNA Expand Its Application Scope	Nature Communications	article	—
2020	DNA Capture by a CRISPR-Cas9 Guided Adenine Base Editor	Science	article	—
2020	Nielsen, S. C.; Eide, C.; Dabelsteen, S.; Wandall, H. H.; Blazar, B. R.; Liu, D. R.; Tolar, J. J. Invest. Derm.	—	article	—
2020	Phage-Assisted Continuous and Non-Continuous Evolution	Nature Protocols	article	—
2020	High-Throughput Analysis of the Activities of xCas9, SpCas9-NG, and SpCas9 at Matched and Mismatched Target Sequences in Human Cells	Nature Biomedical Engineering	article	—
2020	The Developing Toolkit of Continuous Directed Evolution	Nature Chemical Biology	article	—
2020	Glucose Response by Stem Cell-Derived β Cells In Vitro is Inhibited by a Bottleneck in Glycolysis	Cell Reports	article	—
2019	Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2	ACS Synthetic Biology	article	—
2019	Side-Chain Determinants of Biopolymer Function During Iterated Selection and Replication	Nature Chemical Biology	article	—
2019	Simultaneous Targeting of Linked Loci in Mouse Embryos Using Base Editing	Scientific Reports	article	—
2019	Substrate-Selective Inhibitors that Reprogram the Activity of Insulin-Degrading Enzyme	Nature Chemical Biology	article	—
2019	A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9	Cell	article	—
2019	Adenine Base Editing in an Adult Mouse Model of Tyrosinemia	Nature Biomedical Engineering	article	—
2019	An Anionic Human Protein that Mediates Potent Cationic Liposome Delivery of Genome Editing Proteins into Mammalian Cells	Nature Communications	article	—
2019	Development of hRad51–Cas9 Nickase Fusions that Mediate HDR Without Double-Stranded Breaks	Nature Communications	article	—
2019	High-Resolution Specificity Profiling and Off-Target Prediction for Site-Specific DNA Recombinases	Nature Communications	article	—
2019	CRISPResso2: Accurate and Rapid Analysis of Genome Editing Data from Nucleases and Base Editors	Nature Biotechnology	article	—
2019	Circularly Permuted and Modified-PAM Base Editors with Diversified Targeting Scope	Nature Biotechnology	article	—
2018	In Vivo Base Editing of Post-Mitotic Sensory Cells	Nature Communications	article	—
2018	Ensemble CryoEM Elucidates the Mechanism of Insulin Capture and Degradation by Human Insulin Degrading Enzyme	eLife	article	—
2018	Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers	Nature Chemistry	article	—
2018	One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1	Bioconjugate Chemistry	article	—
2018	Editing the Genome Without Double-Stranded DNA Breaks	ACS Chemical Biology	article	—
2018	Development of a Formaldehyde Biosensor with Application to Synthetic Methylotrophy	Biotechnology and Bioengineering	article	—
2018	Second-Generation DNA-Templated Macrocycle Libraries for the Discovery of Bioactive Small Molecules	Nature Chemistry	article	—
2018	Green Fluorescent Proteins Engineered for Cartilage-Targeted Drug Delivery: Insights for Transport into Highly Charged Avascular Tissues	Biomaterials	article	—
2018	Targeting Fidelity of Adenine and Cytosine Base Editors in Mouse Embryos	Nature Communications	article	—
2018	Continuous Directed Evolution of Proteins with Improved Soluble Expression	Nature Chemical Biology	article	—
2017	Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library x Protein Library Selection	Journal of the American Chemical Society	article	—
2017	Crystal Structures Reveal an Elusive Functional Domain of Pyrrolysyl-tRNA Synthetase	Nature Chemical Biology	article	—
2017	Aptazyme-Embedded Guide RNAs Enable Ligand-Responsive Genome Editing and Transcriptional Activation	Nature Communications	article	—
2017	Phage-Assisted Continuous Evolution of Proteases with Altered Substrate Specificity	Nature Communications	article	—
2016	In Situ Regeneration of Bioactive Coatings Enabled by an Evolved Staphylococcus aureus Sortase A	Nature Communications	article	—
2016	Structural and Biochemical Basis for Inhibition of Breast Cancer Cell Migration and Drug-Resistance Mutations by Src-Specific Macrocyclic Inhibitors	Cell chemical biology	article	—
2016	A Programmable Cas9-Serine Recombinase Fusion Protein That Operates on DNA Sequences in Mammalian Cells	Nucleic Acids Research	article	—
2016	Continuous Evolution of B. thuringiensis Toxins Overcomes Insect Resistance	Nature	article	—
2015	In Vivo Continuous Directed Evolution	Current Opinion in Chemical Biology	article	—
2015	Development of Potent In Vivo Mutagenesis Plasmids with Broad Mutational Spectra	Nature Communications	article	—
2015	Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins In Vitro And In Vivo	Journal of the American Chemical Society	article	—
2015	Continuous Directed Evolution of DNA-Binding Domains Generates TALENs with Improved DNA Cleavage Specificity	Nature Methods	article	—
2015	Analytical Devices Based on Direct Synthesis of DNA on Paper	Analytical Chemistry	article	—
2015	Novel Selection Methods for DNA-Encoded Chemical Libraries	Current Opinion in Chemical Biology	article	—
2015	Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases.	Cell chemical biology	article	—
2014	Electrophilic Activity-Based RNA Probes Reveal a Self-Alkylating RNA for RNA Labeling	Nature Chemical Biology	article	—
2014	Reprogramming the Specificity of Sortase Enzymes	Proceedings of the National Academy of Sciences	article	—
2014	A Naturally Occurring, Non-Canonical GTP Aptamer Made of Simple Tandem Repeats	RNA Biology	article	—
2014	Immobilization of Actively Thromnoresistant Assemblies on Sterile Blood-Contacting Surfaces	Advanced Healthcare Materials	article	—
2014	Negative Selection And Stringency Modulation Enable Phage-Assisted Continuous Evolution (PACE) of Enzymes with Altered Specificity	Nature Chemical Biology	article	—
2014	A System For the Continuous Directed Evolution of Proteases Rapidly Reveals Drug-Resistance Mutations	Nature Communications	article	—
2014	Targeted Antithrombotic Protein Micelles	Angewandte Chemie International Edition	article	—
2014	Determining the Specificities of TALENs, Cas9, and Other Genome Editing Enzymes	Methods in enzymology on CD-ROM/Methods in enzymology	article	—
2014	A DNA-Based Molecular Probe for Optically Reporting Cellular Traction Forces	Nature Methods	article	—
2014	Identification of Ligand-Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates	Journal of the American Chemical Society	article	—
2013	A Population-Based Experimental Model for Protein Evolution: Effects of Mutation Rate and Selection Stringency on Evolutionary Outcomes	Biochemistry	article	—
2013	In Silico Abstraction of Zinc Finger Nuclease Cleavage Profiles Reveals an Expanded Landscape of Off-Target Mutations	Nucleic Acids Research	article	—
2013	Discovery of Widespread GTP-Binding Motifs in Genomic DNA and RNA	Chemistry & Biology	article	—
2013	Experimental Interrogation of the Path Dependence and Stochasticity of Protein Evolution Using Phage-Assisted Continuous Evolution	Proceedings of the National Academy of Sciences	article	—
2013	DNA Ligase-Mediated Translation of DNA Into Densely Functionalized Nucleic Acid Polymers	Journal of the American Chemical Society	article	—
2013	Enzyme-Free Translation of DNA into Sequence-Defined Synthetic Polymers Structurally Unrelated to Nucleic Acids	Nature Chemistry	article	—
2012	Discovery and Biological Characterization of Geranylated RNA in Bacteria	Nature Chemical Biology	article	—
2012	Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins	Chemistry & Biology	article	—
2012	Engineering, Identifying, and Applying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells	Methods in enzymology on CD-ROM/Methods in enzymology	article	—
2011	A Biomolecule-Compatible Visible Light-Induced Azide Reduction from a DNA-Encoded Reaction Discovery System	Nature Chemistry	article	—
2011	DNA Enabled Self-Assembly of Plasmonic Nanoclusters	Nano Letters	article	—
2011	A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo	Chemistry & Biology	article	—
2011	A Sequential Strand-Displacement Strategy Enables Efficient Six-Step DNA-Templated Synthesis	Journal of the American Chemical Society	article	—
2011	A De Novo Protein Binding Pair by Computational Design and Directed Evolution	Molecular Cell	article	—
2011	Inhibition of Bacterial Conjugation by Phage M13 and Its Protein g3p: Quantitative Analysis and Model	PLoS ONE	article	—
2011	Directed Evolution of a Small Molecule-Triggered Intein with Improved Splicing Properties in Mammalian Cells	Chemistry & Biology	article	—
2010	Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structure	Journal of the American Chemical Society	article	—
2010	Interaction-Dependent PCR Identifies Target-Ligand Pairs from Libraries of Targets and Ligands	Journal of the American Chemical Society	article	—
2010	Autonomous Multistep Organic Synthesis in a Single Isothermal Solution Mediated by a DNA Walker	Nature Nanotechnology	article	—
2010	Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein	ACS Chemical Biology	article	—
2009	A Chemical Screen for Biological Small Molecule-RNA Conjugates Reveals Coenzyme A-Linked RNA	Proceedings of the National Academy of Sciences	article	—
2009	LC/MS Analysis of Cellular RNA Reveals NAD-Linked RNA	Nature Chemical Biology	article	—
2009	Reactivity-Dependent PCR: Direct, Solution-Phase In Vitro Selection for Bond Formation	Journal of the American Chemical Society	article	—
2009	Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions	Journal of the American Chemical Society	article	—
2009	Recent Progress Towards the Templated Synthesis and Directed Evolution of Sequence-Defined Synthetic Polymers	Chemistry & Biology	article	—
2008	Translation of DNA into a Library of 13,000 Synthetic Small-Molecule Macrocycles Suitable for In Vitro Selection	Journal of the American Chemical Society	article	—
2008	Effects of Template Sequence and Secondary Structure on DNA-Templated Reactivity	Journal of the American Chemical Society	article	—
2007	Identification of Eukaryotic Promoter Regulatory Elements Using Nonhomologous Random Recombination	Nucleic Acids Research	article	—
2007	In Vivo Evolution of an RNA-Based Transcriptional Silencing Domain in S. cerevisiae	Chemistry & Biology	article	—
2007	Solving Chemical Problems Through the Application of Evolutionary Principles	Current Opinion in Chemical Biology	article	—
2007	Synthesis of Acyclic a,b-Unsaturated Ketones via Pd(II)-Catalyzed Intermolecular Reaction of Alkynamides and Alkenes	Journal of the American Chemical Society	article	—
2007	Discovery of a mRNA Mitochondrial Localization Element in Saccharomyces cerevisiae by Nonhomologous Random Recombination and In Vivo Selection	Nucleic Acids Research	article	—
2007	Directed Evolution Can Rapidly Improve the Activity of Chimeric Assembly-Line Enzymes	Proceedings of the National Academy of Sciences	article	—
2007	Dissecting Protein Structure and Function Using Directed Evolution	Nature Methods	article	—
2007	Development and Initial Application of a Hybridization-Independent, DNA-Encoded Reaction Discovery System Compatible with Organic Solvents	Journal of the American Chemical Society	article	—
2006	Binding and Stability Determinants of the PPARg Nuclear Receptor/Coactivator Interface as Revealed by Shotgun Alanine Scanning and In Vivo Selection	Journal of the American Chemical Society	article	—
2006	DNA-Templated Synthesis in Organic Solvents	ChemBioChem	article	—
2006	Bromoenterobactins as Potent Inhibitors of a Pathogen-Associated, Siderophore-Modifying C-Glycosyltransferase	Journal of the American Chemical Society	article	—
2006	Directed Evolution and Substrate Specificity Profile of Homing Endonuclease I-SceI	Journal of the American Chemical Society	article	—
2006	A Protein Interaction Surface in Nonribosomal Peptide Synthesis Mapped by Combinatorial Mutagenesis and Selection	Proceedings of the National Academy of Sciences	article	—
2006	Localized Protein Interaction Surfaces on the EntB Carrier Protein Revealed by Combinatorial Mutagenesis and Selection	Journal of the American Chemical Society	article	—
2006	Control of Transcription Factor Activity and Osteoblast Differentiation in Mammalian Cells Using an Evolved Small-Molecule-Dependent Intein	Journal of the American Chemical Society	article	—
2005	In Vitro Characterization of IroB, a Pathogen-Associated C-Glycosyltransferase	Proceedings of the National Academy of Sciences	article	—
2005	Ordered Multistep Synthesis in a Single Solution Directed by DNA Templates	Angewandte Chemie International Edition	article	—
2005	DNA-Templated Functional Group Transformations Enable Sequence-Programmed Synthesis Using Small-Molecule Reagents	Journal of the American Chemical Society	article	—
2005	Small-Molecule Diversification From Iterated Branching Reaction Pathways Enabled by DNA-Templated Synthesis	Angewandte Chemie International Edition	article	—
2005	Functional Dissection of sRNA Translational Regulators Using Nonhomologous Random Recombination and In Vivo Selection	Chemistry & Biology	article	—
2005	Creating Small Molecule-Dependent Switches to Modulate Biological Functions	Chemistry & Biology	article	—
2005	In Vitro Characterization of Salmochelin and Enterobactin Trilactone Hydrolases IroD, IroE, and Fes	Journal of the American Chemical Society	article	—
2004	Directed Evolution of Ligand Dependence: Small Molecule-Dependent Protein Splicing	Proceedings of the National Academy of Sciences	article	—
2004	Nucleic Acid-Templated Synthesis as a Model System for Ancient Translation	Current Opinion in Chemical Biology	article	—
2004	Directed Evolution of Protein Enzymes Using Nonhomologous Random Recombination	Proceedings of the National Academy of Sciences	article	—

The 300 most cited are listed; 24 more are not.